Title : Pyrrolidine dithiocarbamate inhibits interleukin-6 signaling through impaired STAT3 activation and association with transcriptional coactivators in hepatocytes.

Pub. Date : 2006 Oct 20

PMID : 16926159






1 Functional Relationships(s)
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1 Here we show that treatment of cultured HepG2 hepatoma cells with PDTC inhibits IL-6-stimulated tyrosine phosphorylation and subsequent nuclear translocation of STAT3 in a dose- and time-dependent fashion. Tyrosine interleukin 6 Homo sapiens