PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15284182-3 2004 IL-6 induced prominent tyrosine phosphorylation of the transcription factor STAT1 in both cell types. Tyrosine 23-31 interleukin 6 Homo sapiens 0-4 15665187-11 2005 Moreover, this kinase becomes phosphorylated on tyrosine residues upon sperm treatment with recombinant IL-6, which suggests its activation by the cytokine. Tyrosine 48-56 interleukin 6 Homo sapiens 104-108 15591791-5 2004 Furthermore, vanadate potentiated IL-6-signaling pathway by increasing the tyrosine phosphorylated levels of STAT3 (Tyr705), and Lyn. Tyrosine 75-83 interleukin 6 Homo sapiens 34-38 15313471-5 2004 IL6, but not LIF or OSM inhibited proliferation, induced NE differentiation and tyrosine phosphorylation of STAT3 in LNCaP cells. Tyrosine 80-88 interleukin 6 Homo sapiens 0-3 15010462-2 2004 In this report we show that Grb2-associated binder (Gab) family adapter proteins Gab1 and Gab2 are expressed by multiple myeloma cells; and that interleukin-6 induces their tyrosine phosphorylation and association with downstream signaling molecules. Tyrosine 173-181 interleukin 6 Homo sapiens 145-158 14676217-5 2004 Consistent with the expression of its mRNA, the HG condition also increased the expression of gp130 protein, and phosphorylation of the tyrosine residue by gp130 was enhanced significantly by IL-6/sIL-6R stimulation. Tyrosine 136-144 interleukin 6 Homo sapiens 192-196 14981536-5 2004 Furthermore, we showed that IL6 downstream tyrosine kinase Etk can induce tyrosine phosphorylation of Pim1 which is correlated with its kinase activity. Tyrosine 43-51 interleukin 6 Homo sapiens 28-31 14979481-9 2004 In CD45+ U266 cells, IL-6 increased tyrosine phosphorylation of gp130 and STAT3 and stimulated the level of Mcl-1 protein expression. Tyrosine 36-44 interleukin 6 Homo sapiens 21-25 12974672-1 2004 Signal transducer and activator of transcription 3 (Stat3) dimerization is commonly thought to be triggered by its tyrosine phosphorylation in response to interleukin-6 (IL-6) or other cytokines. Tyrosine 115-123 interleukin 6 Homo sapiens 155-168 12974672-1 2004 Signal transducer and activator of transcription 3 (Stat3) dimerization is commonly thought to be triggered by its tyrosine phosphorylation in response to interleukin-6 (IL-6) or other cytokines. Tyrosine 115-123 interleukin 6 Homo sapiens 170-174 12974672-7 2004 IL-6 induced a 2-fold increase of this basal FRET signal, indicating that tyrosine phosphorylation either increases the dimer/monomer ratio of Stat3 or induces a conformational change of the dimer yielding a higher FRET efficiency. Tyrosine 74-82 interleukin 6 Homo sapiens 0-4 14500551-10 2003 In conclusion, we show that: 1) TGF-beta receptor Type II is predominantly located on basolateral membrane and receptor stimulation activates Smad pathway; 2) TGF-beta1 down-regulates IL-6-induced tyrosine phoshorylation of STAT1 and STAT3 and ICAM-1 expression; and 3) Smad2 is required for the down-regulation of IL-6 signaling by TGF-beta. Tyrosine 197-205 interleukin 6 Homo sapiens 184-188 12952969-6 2003 This effect of IL-6 was accompanied by a marked reduction in IRS-1, but not IRS-2, protein expression, and insulin-stimulated tyrosine phosphorylation, whereas no inhibitory effect was seen on the insulin receptor tyrosine phosphorylation. Tyrosine 126-134 interleukin 6 Homo sapiens 15-19 14500551-7 2003 We show that pretreatment of cells with TGF-beta1 is associated with a down-regulation of IL-6 induced tyrosine phosphorylation of STAT1 and STAT3 and suppression of ICAM-1 expression. Tyrosine 103-111 interleukin 6 Homo sapiens 90-94 14500551-10 2003 In conclusion, we show that: 1) TGF-beta receptor Type II is predominantly located on basolateral membrane and receptor stimulation activates Smad pathway; 2) TGF-beta1 down-regulates IL-6-induced tyrosine phoshorylation of STAT1 and STAT3 and ICAM-1 expression; and 3) Smad2 is required for the down-regulation of IL-6 signaling by TGF-beta. Tyrosine 197-205 interleukin 6 Homo sapiens 315-319 12710894-4 2003 The ability of IL-6 to promote transcription of CRP is mediated, in large part, by activation of the transcription factor STAT3; this activation requires both a tyrosine phosphorylation (mediated by the IL-6 receptor complex) and a serine phosphorylation (Ser-727), the origin of which has been more obscure. Tyrosine 161-169 interleukin 6 Homo sapiens 15-19 12847270-7 2003 15dPGJ(2) also attenuated IL-6-induced tyrosine phosphorylation of STAT1 and STAT3 in Hep3B hepatoma cells. Tyrosine 39-47 interleukin 6 Homo sapiens 26-30 12595539-6 2003 IL-6 increased phosphorylation of STAT3 (at Tyr(705)) and ERK1/2 (at Tyr(204)) within 5 min that peaked at 15-30 min and returned to basal levels at 2 h. Phosphorylation of STAT3 was blocked by genistein, a protein tyrosine kinase inhibitor, and AG490, a JAK2 inhibitor, but not PD98059, an ERK1/2 kinase inhibitor. Tyrosine 44-47 interleukin 6 Homo sapiens 0-4 12595539-6 2003 IL-6 increased phosphorylation of STAT3 (at Tyr(705)) and ERK1/2 (at Tyr(204)) within 5 min that peaked at 15-30 min and returned to basal levels at 2 h. Phosphorylation of STAT3 was blocked by genistein, a protein tyrosine kinase inhibitor, and AG490, a JAK2 inhibitor, but not PD98059, an ERK1/2 kinase inhibitor. Tyrosine 69-72 interleukin 6 Homo sapiens 0-4 12626585-7 2003 In contrast to the IL-6 signal transducer gp130, which has been previously shown to recruit SOCS3 to one of its phosphotyrosine residues (Y759), peptide precipitation experiments suggest that SOCS3 does not interact with phosphorylated tyrosine motifs of the IL-10R. Tyrosine 119-127 interleukin 6 Homo sapiens 19-23 12403768-0 2003 SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130. Tyrosine 29-32 interleukin 6 Homo sapiens 62-75 12403768-2 2003 Tyrosine 759 of the IL-6 signal-transducing receptor subunit gp130 has been identified as being involved in negative regulation of IL-6-induced gene induction and activation of the Jak/STAT pathway. Tyrosine 0-8 interleukin 6 Homo sapiens 20-24 12403768-2 2003 Tyrosine 759 of the IL-6 signal-transducing receptor subunit gp130 has been identified as being involved in negative regulation of IL-6-induced gene induction and activation of the Jak/STAT pathway. Tyrosine 0-8 interleukin 6 Homo sapiens 131-135 12235142-2 2002 Interleukin-6 (IL-6) initiates STAT3 signaling in plasma membrane rafts with the subsequent transit of Tyr-phosphorylated STAT3 (PY-STAT3) through the cytoplasmic compartment to the nucleus in association with accessory proteins. Tyrosine 103-106 interleukin 6 Homo sapiens 0-13 12453891-6 2002 The IL-6 effect is characterized by a decreased tyrosine phosphorylation of IR substrate (IRS)-1 and decreased association of the p85 subunit of phosphatidylinositol 3-kinase with IRS-1 in response to physiologic insulin levels. Tyrosine 48-56 interleukin 6 Homo sapiens 4-8 12235142-2 2002 Interleukin-6 (IL-6) initiates STAT3 signaling in plasma membrane rafts with the subsequent transit of Tyr-phosphorylated STAT3 (PY-STAT3) through the cytoplasmic compartment to the nucleus in association with accessory proteins. Tyrosine 103-106 interleukin 6 Homo sapiens 15-19 11335711-1 2001 Activation of signal transducer and activator of transcription 3 (STAT3) by interleukin-6 (IL-6) involves phosphorylation of Tyr-705 and Ser-727, both of which are critical for STAT3 transactivation. Tyrosine 125-128 interleukin 6 Homo sapiens 76-89 12359225-4 2002 Here, we demonstrate that IL-6-induced tyrosine-phosphorylation and activation of STAT3 were suppressed by overexpression of the nuclear isoform of TC-PTP in 293T cells. Tyrosine 39-47 interleukin 6 Homo sapiens 26-30 11884403-3 2002 However, the membrane-bound IL-6R was nonfunctional, as significant tyrosine phosphorylation of gp130 did not occur in the presence of IL-6. Tyrosine 68-76 interleukin 6 Homo sapiens 28-32 11884403-5 2002 IL-6 complexed with sIL-6R, either exogenously introduced or derived from the nonfunctional cell surface form by shedding, induced rapid tyrosine phosphorylation of gp130. Tyrosine 137-145 interleukin 6 Homo sapiens 0-4 11788581-4 2002 Using high affinity oligosaccharide ligands, it is demonstrated that this lectin activity is responsible for the early dephosphorylation of tyrosine residues found on specific proteins induced by interleukin 6 in human resting lymphocytes. Tyrosine 140-148 interleukin 6 Homo sapiens 196-209 11960349-0 2002 Downregulation of IL-6-induced STAT3 tyrosine phosphorylation by TGF-beta1 is mediated by caspase-dependent and -independent processes. Tyrosine 37-45 interleukin 6 Homo sapiens 18-22 11960349-1 2002 To explore the possible cross-talk between the IL-6 and TGF-beta1 pathways in AML blast cells, the effect of TGF-beta1 pretreatment on IL-6-induced STAT3 tyrosine phosphorylation was studied. Tyrosine 154-162 interleukin 6 Homo sapiens 135-139 11960349-3 2002 The reduced IL-6-mediated STAT3 tyrosine phosphorylation after pre-treatment with TGF-beta1 was associated with apoptosis and coincided with the degradation of certain cellular proteins, including JAK1 and -2 and Tyk2, without affecting the ERK expression and phosphorylation. Tyrosine 32-40 interleukin 6 Homo sapiens 12-16 11960349-4 2002 Furthermore, treatment of AML blasts with the cytostatic agent VP16, as an alternative way to induce apoptosis, resulted in a similar degree of degradation of JAK kinases and concomitant reduction of IL-6-mediated STAT3 tyrosine phosphorylation. Tyrosine 220-228 interleukin 6 Homo sapiens 200-204 11849447-8 2002 RESULTS: IL-6 induced tyrosine phosphorylation and increased the DNA binding activity of STAT3 and, to a lesser extent, STAT1 in all cell lines except for Caki-1, which did not express the IL-6 receptor subunit gp130. Tyrosine 22-30 interleukin 6 Homo sapiens 9-13 11849447-10 2002 IL-6-induced STAT3 tyrosine phosphorylation and DNA binding activity was inhibited by treatment with Jak specific inhibitor AG 490; however, it was not affected by the MEK1 inhibitor PD 98059. Tyrosine 19-27 interleukin 6 Homo sapiens 0-4 11594781-1 2001 We previously demonstrated that exposure of CCL39 lung fibroblasts to alpha-thrombin inhibits interleukin-6 (IL-6)-induced tyrosine phosphorylation of Stat3 (signal transducers and activators of transcription 3) via activation of mitogen-activated protein (MAP) kinase kinase 1 [Bhat et al. Tyrosine 123-131 interleukin 6 Homo sapiens 94-107 11594781-1 2001 We previously demonstrated that exposure of CCL39 lung fibroblasts to alpha-thrombin inhibits interleukin-6 (IL-6)-induced tyrosine phosphorylation of Stat3 (signal transducers and activators of transcription 3) via activation of mitogen-activated protein (MAP) kinase kinase 1 [Bhat et al. Tyrosine 123-131 interleukin 6 Homo sapiens 109-113 11594781-8 2001 We demonstrate that, although both IL-6 and OSM belong to the same cytokine family, alpha-thrombin inhibited only the IL-6-induced Stat3 tyrosine phosphorylation. Tyrosine 137-145 interleukin 6 Homo sapiens 118-122 11574475-3 2001 The IFNGR1 signal-transducing subunit of the IFN-gamma receptor is tyrosine phosphorylated through the chimeric receptors and the endogenous IL-6 and OSM receptors. Tyrosine 67-75 interleukin 6 Homo sapiens 141-145 12360405-9 2002 These results indicate that the MAPK pathway plays a critical role in IL-6 mediated tyrosine phosphorylation of STAT3 and suggests that Jak kinases may not be required in this cascade. Tyrosine 84-92 interleukin 6 Homo sapiens 70-74 12119038-1 2002 Suppressor of cytokine signaling-3 (SOCS-3) and the protein tyrosine phosphatase SHP-2 both regulate signaling by cytokines of the interleukin-6 family, and this is dependent upon recruitment to tyrosine 757 in the shared cytokine receptor subunit gp130. Tyrosine 60-68 interleukin 6 Homo sapiens 131-144 11815625-5 2002 Upon activation of signaling by IL-6 or orthovanadate the respective Tyr-phosphorylated STAT species were now also observed in the membrane raft fraction but in a form deficient in DNA binding. Tyrosine 69-72 interleukin 6 Homo sapiens 32-36 11335711-1 2001 Activation of signal transducer and activator of transcription 3 (STAT3) by interleukin-6 (IL-6) involves phosphorylation of Tyr-705 and Ser-727, both of which are critical for STAT3 transactivation. Tyrosine 125-128 interleukin 6 Homo sapiens 91-95 11154231-7 2001 In the OH-2 and ANBL-6 cell lines and in a patient sample, immunoblotting showed that BMP-4 down-regulated IL-6-induced tyrosine phosphorylation of Stat3, suggesting a mechanism for the apparent antagonism between IL-6 and BMP-4. Tyrosine 120-128 interleukin 6 Homo sapiens 107-111 11473581-6 2001 We provide evidence that the cytoplasmic tyrosine residues of IFNAR-1, which remains phosphorylated by a weak IFN-alpha/beta stimulation, provide docking sites for Stat1 and Stat3 to form homo- or heterodimers following IL-6 stimulation. Tyrosine 41-49 interleukin 6 Homo sapiens 220-224 11337018-5 2001 STAT3 antisense cDNA blocked the expression and IL-6-induced tyrosine phosphorylation and DNA binding of STAT3, and resulted in reduction of both IL-6-induced growth arrest at G(0)/G(1) phase and macrophage differentiation in the M1 transformants. Tyrosine 61-69 interleukin 6 Homo sapiens 48-52 11337018-5 2001 STAT3 antisense cDNA blocked the expression and IL-6-induced tyrosine phosphorylation and DNA binding of STAT3, and resulted in reduction of both IL-6-induced growth arrest at G(0)/G(1) phase and macrophage differentiation in the M1 transformants. Tyrosine 61-69 interleukin 6 Homo sapiens 146-150 11429693-8 2001 Thus, the YXXQ motif regulates STAT3 activities in two ways in response to even a low concentration of IL-6: it recruits STAT3 to the receptor for tyrosine phosphorylation, and activates an unidentified H7-sensitive pathway leading to the serine phosphorylation of STAT3. Tyrosine 147-155 interleukin 6 Homo sapiens 103-107 11270639-8 2001 CONCLUSIONS: IL-6 up-regulates uterine OTR mRNA expression and binding capacity in cultured human myocytes most likely through tyrosine and serine phosphorylation pathways involving the nuclear factor STAT-3. Tyrosine 127-135 interleukin 6 Homo sapiens 13-17 11162290-4 2000 Stimulation of macrophages with either CNTFRalpha in combination with CNTF or IL-6 alone resulted in tyrosine phosphorylation of an approximately 130 kD protein, presumed to be gp130. Tyrosine 101-109 interleukin 6 Homo sapiens 78-82 11196191-12 2001 On IL-6 stimulation, SHP-2 and Gab1 were recruited to the gp130 subunit of the IL-6 receptor and tyrosine phosphorylated, allowing downstream signaling to the MAPK and PI3K pathways. Tyrosine 97-105 interleukin 6 Homo sapiens 3-7 11196191-12 2001 On IL-6 stimulation, SHP-2 and Gab1 were recruited to the gp130 subunit of the IL-6 receptor and tyrosine phosphorylated, allowing downstream signaling to the MAPK and PI3K pathways. Tyrosine 97-105 interleukin 6 Homo sapiens 79-83 11104703-3 2000 Furthermore, IL-1beta selectively down-regulated the IL-6-induced tyrosine phosphorylation of STAT1 without affecting the level of STAT1 or tyrosine phosphorylation of STAT3. Tyrosine 66-74 interleukin 6 Homo sapiens 53-57 11027495-6 2000 Studies on the mode of action revealed that CPDHC (1) affects the IL-6-dependent pathway by inhibiting the tyrosine phosphorylation of the STAT3 and STAT1 as well as the serine phosphorylation of the Stat3 transcription factor. Tyrosine 107-115 interleukin 6 Homo sapiens 66-70 11046056-4 2000 IL-1, TNF-alpha, and LPS blocked the activation of Stat DNA binding and tyrosine phosphorylation by IL-6 and IL-10, but not by IFN-gamma, in primary macrophages. Tyrosine 72-80 interleukin 6 Homo sapiens 100-104 10982829-5 2000 Our results indicate that the coiled-coil domain is essential for Stat3 recruitment to the receptor and the subsequent tyrosine phosphorylation and tyrosine phosphorylation-dependent activities, such as dimer formation, nuclear translocation, and DNA binding, stimulated by epidermal growth factor (EGF) or interleukin-6 (IL-6). Tyrosine 119-127 interleukin 6 Homo sapiens 307-320 10982829-5 2000 Our results indicate that the coiled-coil domain is essential for Stat3 recruitment to the receptor and the subsequent tyrosine phosphorylation and tyrosine phosphorylation-dependent activities, such as dimer formation, nuclear translocation, and DNA binding, stimulated by epidermal growth factor (EGF) or interleukin-6 (IL-6). Tyrosine 119-127 interleukin 6 Homo sapiens 322-326 10982829-5 2000 Our results indicate that the coiled-coil domain is essential for Stat3 recruitment to the receptor and the subsequent tyrosine phosphorylation and tyrosine phosphorylation-dependent activities, such as dimer formation, nuclear translocation, and DNA binding, stimulated by epidermal growth factor (EGF) or interleukin-6 (IL-6). Tyrosine 148-156 interleukin 6 Homo sapiens 307-320 10982829-5 2000 Our results indicate that the coiled-coil domain is essential for Stat3 recruitment to the receptor and the subsequent tyrosine phosphorylation and tyrosine phosphorylation-dependent activities, such as dimer formation, nuclear translocation, and DNA binding, stimulated by epidermal growth factor (EGF) or interleukin-6 (IL-6). Tyrosine 148-156 interleukin 6 Homo sapiens 322-326 10946280-8 2000 Interestingly, one SHP2-recruiting phosphotyrosine motif in a single chain of the gp130 dimer is sufficient to mediate SHP2 association to the gp130 receptor subunit and its tyrosine phosphorylation as well as to attenuate IL-6-dependent gene induction. Tyrosine 42-50 interleukin 6 Homo sapiens 223-227 10764798-0 2000 The inhibition of interleukin-6-dependent STAT activation by mitogen-activated protein kinases depends on tyrosine 759 in the cytoplasmic tail of glycoprotein 130. Tyrosine 106-114 interleukin 6 Homo sapiens 18-31 10579793-6 2000 RESULTS: Tyrosine phosphorylation of p85 is upregulated by IL-6 in both LNCaP and PC-3. Tyrosine 9-17 interleukin 6 Homo sapiens 59-63 10777583-6 2000 Furthermore, we show that tyrosine 759 in gp130 is essential for both SHP2 and SOCS3 but not for SOCS1 to exert their inhibitory activities on interleukin-6 signal transduction. Tyrosine 26-34 interleukin 6 Homo sapiens 143-156 10847629-7 2000 Tyrosine phosphorylation of both Stat5a and Stat5b was induced by IL-6. Tyrosine 0-8 interleukin 6 Homo sapiens 66-70 10636920-1 2000 The role of signal transducer and activator of transcription (STAT) signaling pathways in the interleukin-6 (IL-6)-induced morphological differentiation of PC12-E2 cells was assessed using wild type and dominant negative mutants of Stat1 and Stat3, containing Tyr --> Phe (YF), Ser --> Ala (SA), and the double mutations (DM), respectively. Tyrosine 260-263 interleukin 6 Homo sapiens 94-107 10636920-1 2000 The role of signal transducer and activator of transcription (STAT) signaling pathways in the interleukin-6 (IL-6)-induced morphological differentiation of PC12-E2 cells was assessed using wild type and dominant negative mutants of Stat1 and Stat3, containing Tyr --> Phe (YF), Ser --> Ala (SA), and the double mutations (DM), respectively. Tyrosine 260-263 interleukin 6 Homo sapiens 109-113 10080949-1 1999 Exposure of primary human lung fibroblasts (HLF) to interleukin-6 (IL-6) rapidly induced Stat3 (signal transducers and activators of transcription 3) tyrosine phosphorylation. Tyrosine 150-158 interleukin 6 Homo sapiens 52-65 10438468-5 1999 IL-6 stimulation of hepatoma cells induced a rapid tyrosine phosphorylation of the p85 subunit of phosphatidylinositol 3-kinase (PI 3-kinase) and its kinase activity followed by the activation of Akt. Tyrosine 51-59 interleukin 6 Homo sapiens 0-4 10381520-9 1999 Further analysis, comparing the parental OPM-2 cells and a representative transfectant, clone C5, showed that IL-6 caused rapid tyrosine phosphorylation of gp130 in both OPM-2 and C5 clones. Tyrosine 128-136 interleukin 6 Homo sapiens 110-114 10360689-20 1999 Macrophage release of TNF-alpha and IL-6 in response to particles coincided with increased tyrosine phosphorylation and mitogen-activated protein kinase activation. Tyrosine 91-99 interleukin 6 Homo sapiens 36-40 10360689-25 1999 CONCLUSIONS: These data suggest that particle induced macrophage release of TNF-alpha and IL-6 does not require phagocytosis but is dependent on tyrosine and serine/threonine kinase activity culminating in activation of Tyrosine 145-153 interleukin 6 Homo sapiens 90-94 10080949-1 1999 Exposure of primary human lung fibroblasts (HLF) to interleukin-6 (IL-6) rapidly induced Stat3 (signal transducers and activators of transcription 3) tyrosine phosphorylation. Tyrosine 150-158 interleukin 6 Homo sapiens 67-71 10080949-3 1999 Interestingly, a short pretreatment of cells with alpha-thrombin significantly inhibited IL-6-induced tyrosine phosphorylation of Stat3. Tyrosine 102-110 interleukin 6 Homo sapiens 89-93 9891500-8 1998 RESULTS: IL-6 induced tyrosine-phosphorylated proteins in LNCaP but not in PC-3 or DU 145, indicating that LNCaP cells express the functional IL-6 receptor. Tyrosine 22-30 interleukin 6 Homo sapiens 9-13 10368647-2 1999 Tyrosine phosphorylation of the transcription factor STAT3 plays an important role in IL-6 cytokine family-mediated reactions. Tyrosine 0-8 interleukin 6 Homo sapiens 86-90 9794795-3 1998 The tyrosine phosphorylated STAT factors dissociate from the receptor, dimerize and translocate to the nucleus where they bind to enhancer sequences of IL-6 target genes. Tyrosine 4-12 interleukin 6 Homo sapiens 152-156 9891500-8 1998 RESULTS: IL-6 induced tyrosine-phosphorylated proteins in LNCaP but not in PC-3 or DU 145, indicating that LNCaP cells express the functional IL-6 receptor. Tyrosine 22-30 interleukin 6 Homo sapiens 142-146 9712900-5 1998 By measuring cellular responses, such as morphological changes upon differentiation, soft agar colony formation, and induction of tyrosine phosphorylation of the signal transducer and activator of transcription, STAT3, we show that signaling by IL-6, but not LIF, is significantly reduced by mutations in the Ig-like module of gp130. Tyrosine 130-138 interleukin 6 Homo sapiens 245-249 9647240-5 1998 Despite a reduction in IL-6-induced STAT3 DNA binding activity in the nuclear compartment during STAT-masking, there was increased and prolonged accumulation of tyrosine-phosphorylated STAT3 in both the cytoplasmic and nuclear compartments, indicating that the capacity of tyrosine-phosphorylated STAT3 to bind DNA was reduced during STAT-masking. Tyrosine 161-169 interleukin 6 Homo sapiens 23-27 9692957-1 1998 A noncovalently bound dimeric form of recombinant human IL-6 interleukin-6 (IL-6D) was shown to be an antagonist for IL-6 activity, in a STAT3 tyrosine phosphorylation assay using HepG2 cells, under conditions where it does not dissociate into monomeric IL-6 (IL-6M). Tyrosine 143-151 interleukin 6 Homo sapiens 56-60 9692957-1 1998 A noncovalently bound dimeric form of recombinant human IL-6 interleukin-6 (IL-6D) was shown to be an antagonist for IL-6 activity, in a STAT3 tyrosine phosphorylation assay using HepG2 cells, under conditions where it does not dissociate into monomeric IL-6 (IL-6M). Tyrosine 143-151 interleukin 6 Homo sapiens 61-74 9692957-1 1998 A noncovalently bound dimeric form of recombinant human IL-6 interleukin-6 (IL-6D) was shown to be an antagonist for IL-6 activity, in a STAT3 tyrosine phosphorylation assay using HepG2 cells, under conditions where it does not dissociate into monomeric IL-6 (IL-6M). Tyrosine 143-151 interleukin 6 Homo sapiens 76-80 9692957-1 1998 A noncovalently bound dimeric form of recombinant human IL-6 interleukin-6 (IL-6D) was shown to be an antagonist for IL-6 activity, in a STAT3 tyrosine phosphorylation assay using HepG2 cells, under conditions where it does not dissociate into monomeric IL-6 (IL-6M). Tyrosine 143-151 interleukin 6 Homo sapiens 76-80 9647240-5 1998 Despite a reduction in IL-6-induced STAT3 DNA binding activity in the nuclear compartment during STAT-masking, there was increased and prolonged accumulation of tyrosine-phosphorylated STAT3 in both the cytoplasmic and nuclear compartments, indicating that the capacity of tyrosine-phosphorylated STAT3 to bind DNA was reduced during STAT-masking. Tyrosine 273-281 interleukin 6 Homo sapiens 23-27 9590694-3 1998 Here we show that treatment of the prostate cancer cell line LNCaP with IL-6 induces tyrosine phosphorylation of ErbB2 and ErbB3, but not ErbB1/EGFR. Tyrosine 85-93 interleukin 6 Homo sapiens 72-76 9013873-0 1997 Vav is associated with signal transducing molecules gp130, Grb2 and Erk2, and is tyrosine phosphorylated in response to interleukin-6. Tyrosine 81-89 interleukin 6 Homo sapiens 120-133 9322921-4 1997 Furthermore, interleukin-6-induced tyrosine phosphorylation can occur independent of serine phosphorylation, demonstrating that these two phosphorylation pathways are mechanistically unrelated. Tyrosine 35-43 interleukin 6 Homo sapiens 13-26 9164976-6 1997 Immunoblot analysis revealed sIL-6R alpha/IL-6- or OM-induced tyrosine phosphorylation of a similar set of proteins in KS cells, and which was augmented significantly in Dex-treated KS cells. Tyrosine 62-70 interleukin 6 Homo sapiens 30-34 9164976-7 1997 Stimulation of KS cells with sIL-6R alpha/IL-6 or OM induced rapid tyrosine phosphorylation of the transcription factor STAT3, and Dex significantly enhanced the accumulation of tyrosine-phosphorylated STAT3. Tyrosine 67-75 interleukin 6 Homo sapiens 30-34 9164976-7 1997 Stimulation of KS cells with sIL-6R alpha/IL-6 or OM induced rapid tyrosine phosphorylation of the transcription factor STAT3, and Dex significantly enhanced the accumulation of tyrosine-phosphorylated STAT3. Tyrosine 178-186 interleukin 6 Homo sapiens 30-34 9184420-3 1997 The IL-6/sIL-6R complex was also able to rapidly induce tyrosine phosphorylation of the IL-6 transducer, gp130. Tyrosine 56-64 interleukin 6 Homo sapiens 4-8 9184420-3 1997 The IL-6/sIL-6R complex was also able to rapidly induce tyrosine phosphorylation of the IL-6 transducer, gp130. Tyrosine 56-64 interleukin 6 Homo sapiens 10-14 9610741-6 1998 Upon stimulation with IL-6/sIL-6R, the gp130, cytoplasmic Janus kinases JAK1 and JAK2 were tyrosine phosphorylated. Tyrosine 91-99 interleukin 6 Homo sapiens 22-26 9505191-6 1998 JAK tyrosine kinase is a key molecule that can initiate multiple signal-transduction pathways by inducing the tyrosine-phosphorylation of the cytokine receptor, gp130 in the case of IL-6, on which several signaling molecules are recruited, including STAT, a signal transducer and activator of transcription, and SHP-2, which links to the Ras-MAP kinase pathway. Tyrosine 4-12 interleukin 6 Homo sapiens 182-186 9558728-11 1998 In addition to the tyrosine phosphorylation we have observed that IL-6 also induces a serine phosphorylation of STAT3. Tyrosine 19-27 interleukin 6 Homo sapiens 66-70 9406996-4 1997 In the IL-6-dependent cell line B-9, IL-6 induced a rapid, transient, and concentration-dependent tyrosine phosphorylation of several cytosolic proteins as detected by antiphosphotyrosine immunoblots. Tyrosine 98-106 interleukin 6 Homo sapiens 7-11 9406996-4 1997 In the IL-6-dependent cell line B-9, IL-6 induced a rapid, transient, and concentration-dependent tyrosine phosphorylation of several cytosolic proteins as detected by antiphosphotyrosine immunoblots. Tyrosine 98-106 interleukin 6 Homo sapiens 37-41 9406996-6 1997 Similar effects of IL-6 on tyrosine phosphorylation were observed in the human multiple myeloma cell line LP-1. Tyrosine 27-35 interleukin 6 Homo sapiens 19-23 9406996-8 1997 IL-6 induced the activation and tyrosine phosphorylation of p59Fyn, p56/59Hck, and p56Lyn. Tyrosine 32-40 interleukin 6 Homo sapiens 0-4 9202212-3 1997 Using the tyrosine phosphorylation inhibitor, genistein, and electrophoretic mobility shift assay, we show that IL-6 and IFN-gamma induce nuclear factor STAT-3 and STAT-1 DNA-binding activity to the sis-inducible element of c-fos in a genistein-dependent pathway. Tyrosine 10-18 interleukin 6 Homo sapiens 112-116 9126968-7 1997 IL-6 was shown to promote the rapid tyrosine phosphorylation of gp130, Jak2, and Shc proteins. Tyrosine 36-44 interleukin 6 Homo sapiens 0-4 9013873-2 1997 We show that interleukin-6 (IL-6) induces transient tyrosine phosphorylation of Vav in a human myeloma cell line, U266. Tyrosine 52-60 interleukin 6 Homo sapiens 13-26 9013873-2 1997 We show that interleukin-6 (IL-6) induces transient tyrosine phosphorylation of Vav in a human myeloma cell line, U266. Tyrosine 52-60 interleukin 6 Homo sapiens 28-32 9013873-3 1997 A membrane-distal part of the cytoplasmic region of gp130 is critical for association between Vav and gp130, and the IL-6-induced tyrosine phosphorylation of Vav. Tyrosine 130-138 interleukin 6 Homo sapiens 117-121 8978300-4 1997 Prior treatment of U266 cells with IFN-beta downregulated IL-6-induced tyrosine phosphorylation of gp130, Jak2, PTP1D/Syp, Shc, and Erk2, and GTP-loading of p21ras. Tyrosine 71-79 interleukin 6 Homo sapiens 58-62 8978300-3 1997 IL-6 induced transient tyrosine phosphorylation of the IL-6-receptor signal-transducing subunit gp130, the gp130-associated protein tyrosine kinases Jak1,Jak2, and Tyk2, the phosphotyrosine phosphatase PTP1D/Syp, the adaptor protein Shc and the mitogen-activated protein kinase Erk2, and accumulation of GTP-bound p21ras. Tyrosine 23-31 interleukin 6 Homo sapiens 0-4 8978300-3 1997 IL-6 induced transient tyrosine phosphorylation of the IL-6-receptor signal-transducing subunit gp130, the gp130-associated protein tyrosine kinases Jak1,Jak2, and Tyk2, the phosphotyrosine phosphatase PTP1D/Syp, the adaptor protein Shc and the mitogen-activated protein kinase Erk2, and accumulation of GTP-bound p21ras. Tyrosine 23-31 interleukin 6 Homo sapiens 55-59 8978300-5 1997 Further analysis indicated that treatment with IFN-beta disrupted IL-6-induced binding of PTP1D/Syp to gp130 and the adaptor protein Grb2; IFN-beta pretreatment also interfered with IL-6-induced interaction of Shc with Grb2 and a 145-kD tyrosine-phosphorylated protein. Tyrosine 237-245 interleukin 6 Homo sapiens 66-70 8978300-5 1997 Further analysis indicated that treatment with IFN-beta disrupted IL-6-induced binding of PTP1D/Syp to gp130 and the adaptor protein Grb2; IFN-beta pretreatment also interfered with IL-6-induced interaction of Shc with Grb2 and a 145-kD tyrosine-phosphorylated protein. Tyrosine 237-245 interleukin 6 Homo sapiens 182-186 8809410-9 1996 The examination of tyrosine phosphorylation of gp130 (as an early event in IL-6 signal transduction) revealed that gp130 could be phosphorylated in all cell lines after stimulation with IL-6 and/or IL-6 + sIL-6R. Tyrosine 19-27 interleukin 6 Homo sapiens 75-79 8798409-1 1996 We reported recently that angiotensin II (AII) and phorbol 12-myristate 13-acetate (PMA) transiently inhibit interleukin 6 (IL-6)-stimulated tyrosine phosphorylation of signal transducers and activators of transcription 3 (Stat3) and subsequent formation of sis-inducing factor-A (SIF-A). Tyrosine 141-149 interleukin 6 Homo sapiens 109-122 8798409-1 1996 We reported recently that angiotensin II (AII) and phorbol 12-myristate 13-acetate (PMA) transiently inhibit interleukin 6 (IL-6)-stimulated tyrosine phosphorylation of signal transducers and activators of transcription 3 (Stat3) and subsequent formation of sis-inducing factor-A (SIF-A). Tyrosine 141-149 interleukin 6 Homo sapiens 124-128 8798409-9 1996 Treatment of cells with PD98059, a specific inhibitor of MAPKK1, attenuated the inhibitory effects of AII and PMA on IL-6-induced Stat3 tyrosine phosphorylation and SIF-A formation. Tyrosine 136-144 interleukin 6 Homo sapiens 117-121 8912909-0 1996 Human olfactory neuroepithelial cells: tyrosine phosphorylation and process extension are increased by the combination of IL-1beta, IL-6, NGF, and bFGF. Tyrosine 39-47 interleukin 6 Homo sapiens 132-136 8662795-9 1996 271, 12991-12998), we demonstrated that two tyrosine motifs within the cytoplasmic part of the interleukin 6 signal transducer gp130 specifically mediate APRF activation while two others can recruit both APRF and Stat1. Tyrosine 44-52 interleukin 6 Homo sapiens 95-108 8662591-7 1996 We have analyzed by mutational studies and by phosphopeptide competition assays which of the tyrosine modules of the IL-6 signal transducer gp130 are capable of recruiting either APRF or STAT1. Tyrosine 93-101 interleukin 6 Homo sapiens 117-121 8632998-3 1996 In the case of IL-6 and LIF, which share a signal transducing receptor gp130, STAT3 is specifically tyrosine-phosphorylated and activated by stimulation with each cytokine in various cell types. Tyrosine 100-108 interleukin 6 Homo sapiens 15-19 8650263-6 1996 Data from the IL2, IL6 and IFN systems indicate a major role for the tyrosine phosphorylated receptor/JAK complexes (rather than substrate specificity of the JAKs per se) in STAT selection. Tyrosine 69-77 interleukin 6 Homo sapiens 19-30 8626374-1 1996 Interleukin-6 (IL-6) induces tyrosine phosphorylation and activation of the latent transcription factor Stat3 in HepG2 cells. Tyrosine 29-37 interleukin 6 Homo sapiens 0-13 8626374-1 1996 Interleukin-6 (IL-6) induces tyrosine phosphorylation and activation of the latent transcription factor Stat3 in HepG2 cells. Tyrosine 29-37 interleukin 6 Homo sapiens 15-19 8626374-2 1996 Mutation of Stat3 tyrosine 705 to phenylalanine (Y705F) inhibits IL-6-induced tyrosine phosphorylation of this Stat3 mutant in transfected HepG2 cells. Tyrosine 18-26 interleukin 6 Homo sapiens 65-69 7581271-1 1995 Porphyromonas gingivalis 381 fimbriae and a synthetic peptide composed of residues 69-73 (ALTTE) of the fimbrial subunit protein, FP381(69-73), function in the induction of interleukin 6 (IL-6) production, IL-6 mRNA expression, and tyrosine and serine/threonine phosphorylation of several proteins in human peripheral blood mononuclear cells (PBMC). Tyrosine 232-240 interleukin 6 Homo sapiens 173-186 8617307-0 1996 Interleukin-6 induces tyrosine phosphorylation of the Ras activating protein Shc, and its complex formation with Grb2 in the human multiple myeloma cell line LP-1. Tyrosine 22-30 interleukin 6 Homo sapiens 0-13 7561108-9 1995 Pretreatment of EC with the tyrosine kinase inhibitor, herbimycin A, inhibited LPS-stimulated protein tyrosine phosphorylation and LPS-mediated lactic dehydrogenase release from BBMEC and IL-6 release from HBMEC in a dose-dependent manner. Tyrosine 28-36 interleukin 6 Homo sapiens 188-192 7642569-10 1995 We tested the hypothesis that AII initially activated an inhibitory pathway, which was responsible for delaying the maximal SIF stimulation until 2 h. Pretreatment of cells for 15 min with AII resulted in significant inhibition of the IL-6 induced nuclear SIF response (10 min) and Stat92 tyrosine phosphorylation, which was blocked by EXP3174, an AT1 receptor antagonist. Tyrosine 289-297 interleukin 6 Homo sapiens 235-239 7521688-4 1994 We also demonstrate that the DNA-binding protein STAT3 (also called the acute-phase response factor [APRF], activated by interleukin-6) is an early target of G-CSF-induced tyrosine phosphorylation. Tyrosine 172-180 interleukin 6 Homo sapiens 121-134 7533107-1 1995 The cytokine interleukin-6 (IL-6) rapidly activates a latent cytoplasmic transcription factor, acute-phase response factor (APRF), by tyrosine phosphorylation. Tyrosine 134-142 interleukin 6 Homo sapiens 13-26 7533107-1 1995 The cytokine interleukin-6 (IL-6) rapidly activates a latent cytoplasmic transcription factor, acute-phase response factor (APRF), by tyrosine phosphorylation. Tyrosine 134-142 interleukin 6 Homo sapiens 28-32 7963520-3 1994 IL-6 also induced tyrosine phosphorylation of the signaling transducing subunit of the IL-6R in AF10 cells, along with tyrosine phosphorylation of the gp130-associated tyrosine protein kinase JAK1 and the adaptor molecule p52shc. Tyrosine 18-26 interleukin 6 Homo sapiens 0-4 7963520-3 1994 IL-6 also induced tyrosine phosphorylation of the signaling transducing subunit of the IL-6R in AF10 cells, along with tyrosine phosphorylation of the gp130-associated tyrosine protein kinase JAK1 and the adaptor molecule p52shc. Tyrosine 119-127 interleukin 6 Homo sapiens 0-4 7963520-4 1994 Although induction of tyrosine phosphorylation and activation of MAP kinase by IL-6 in a differentiation-responsive B cell line, SKW 6.4, were below the limits of detection, the phorbol ester PMA did activate Raf-1, MEK-1, and MAP kinase without inducing the phosphorylation of gp130, JAKs, or p52shc. Tyrosine 22-30 interleukin 6 Homo sapiens 79-83 7523403-3 1994 In mammary cells or hybridoma B9 cells, four distinct tyrosine-phosphorylated transcription complexes activated by interleukin-6 (IL-6) and IFN-beta were observed: pIRFA and complexes I, II, and III (of increasing electrophoretic mobility). Tyrosine 54-62 interleukin 6 Homo sapiens 115-128 7523403-3 1994 In mammary cells or hybridoma B9 cells, four distinct tyrosine-phosphorylated transcription complexes activated by interleukin-6 (IL-6) and IFN-beta were observed: pIRFA and complexes I, II, and III (of increasing electrophoretic mobility). Tyrosine 54-62 interleukin 6 Homo sapiens 130-134 7518681-3 1994 Interestingly, the Stat91 transcription factor essential for interferon signaling mediated by JAK-TYK kinases was significantly tyrosine phosphorylated in response to IL-6 in ANBL-6 cells but not in the other cell lines. Tyrosine 128-136 interleukin 6 Homo sapiens 167-171 7518681-4 1994 We further show that IL-11, a cytokine that signals via the gp130 subunit of the IL-6 receptor, induced similar profiles of JAK-TYK tyrosine phosphorylation as IL-6 in B9E and T10D cells. Tyrosine 132-140 interleukin 6 Homo sapiens 81-85 7512451-4 1994 The cloned APRF protein is tyrosine phosphorylated and translocated into the nucleus in response to IL-6, but not in response to IFN-gamma. Tyrosine 27-35 interleukin 6 Homo sapiens 100-104 7812050-1 1994 Recent evidence has shown that members of the Jak kinase family are activated after IL-6 binds to its receptor complex, leading to a tyrosine phosphorylation of gp130, the IL-6 signal-transducing subunit. Tyrosine 133-141 interleukin 6 Homo sapiens 84-88 7812050-1 1994 Recent evidence has shown that members of the Jak kinase family are activated after IL-6 binds to its receptor complex, leading to a tyrosine phosphorylation of gp130, the IL-6 signal-transducing subunit. Tyrosine 133-141 interleukin 6 Homo sapiens 172-176 7512571-0 1994 Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors. Tyrosine 110-118 interleukin 6 Homo sapiens 55-68 7512571-2 1994 Here we report that CNTF, LIF, OSM, and IL6 induce most of the same protein tyrosine phosphorylations, regardless of the cell type assayed or whether they initiate signaling by inducing homo- or heterodimerization of beta components. Tyrosine 76-84 interleukin 6 Homo sapiens 40-43 7515712-3 1994 In this study, we showed that hematopoietic cytokines, such as IL-3, IL-6, and G-CSF, all induced tyrosine-phosphorylation of Stat family proteins and Stat-associated 150-kD and 72-kD molecules in hematopoietic lineage cell lines. Tyrosine 98-106 interleukin 6 Homo sapiens 69-73 7512451-5 1994 Tyrosine phosphorylation was also observed in response to other cytokines, such as leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor, whose receptors share the IL-6 receptor signal transducer gp130. Tyrosine 0-8 interleukin 6 Homo sapiens 184-188 8360477-5 1993 The results showed that IL-11 and IL-6 can both stimulate cell proliferation, induce similar pattern of protein tyrosine phosphorylation, and activate the same proto-oncogene (junB) expression in TF-1 cells. Tyrosine 112-120 interleukin 6 Homo sapiens 34-38 8140422-0 1994 Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Tyrosine 41-49 interleukin 6 Homo sapiens 109-122 8140422-2 1994 A new family member, Stat3, becomes activated through phosphorylation on tyrosine as a DNA binding protein in response to epidermal growth factor (EGF) and interleukin-6 (IL-6) but not interferon gamma (IFN-gamma). Tyrosine 73-81 interleukin 6 Homo sapiens 156-169 8140422-2 1994 A new family member, Stat3, becomes activated through phosphorylation on tyrosine as a DNA binding protein in response to epidermal growth factor (EGF) and interleukin-6 (IL-6) but not interferon gamma (IFN-gamma). Tyrosine 73-81 interleukin 6 Homo sapiens 171-175 7696968-6 1994 After tyrosine specific phosphorylation of APRF, it translocates into nuclei, binds to type 2 IL-6 responsive element and induces acute phase gene expression. Tyrosine 6-14 interleukin 6 Homo sapiens 94-98 8397445-3 1993 Epidermal growth factor, interferon-gamma, and interleukin-6 all activated, through direct tyrosine phosphorylation, latent cytoplasmic transcription factors that recognized similar DNA elements. Tyrosine 91-99 interleukin 6 Homo sapiens 47-60 7688764-10 1993 However, r.IL-6 did stimulate tyrosine phosphorylation and p42MAPK activity in the human B cell line, AF-10, while OSM and LIF exerted no effects. Tyrosine 30-38 interleukin 6 Homo sapiens 11-15 1623564-4 1992 At concentrations of greater than or equal to 10 nM, CRF and two analogous peptides (Tyr-CRF and alpha-helical CRF) elicited 16- to 21-fold stimulation of IL-6 production by MNC. Tyrosine 85-88 interleukin 6 Homo sapiens 155-159 1292471-6 1992 Results from protein tyrosine phosphorylation and immediate response gene expression suggest that there are convergent and divergent points along the signal transduction pathways utilized by IL-6 or IL-11. Tyrosine 21-29 interleukin 6 Homo sapiens 191-195 8421678-2 1993 It is reported here that IL-6 reduced by 5- to 20-fold the tyrosine phosphorylation of cellular proteins in these cells. Tyrosine 59-67 interleukin 6 Homo sapiens 25-29 1908551-0 1991 Leukemia inhibitory factor and interleukin-6 trigger the same immediate early response, including tyrosine phosphorylation, upon induction of myeloid leukemia differentiation. Tyrosine 98-106 interleukin 6 Homo sapiens 31-44 1376256-7 1992 Independent of cAMP, by tyrosine phosphorylation of specific substrates IL-1 also induces c-myc and IL-6 mRNA expression and cellular proliferation. Tyrosine 24-32 interleukin 6 Homo sapiens 100-104 1662392-7 1991 Loss of signal-transducing ability of gp130 with such a mutation coincided with disappearance of IL-6-induced tyrosine phosphorylation of gp130. Tyrosine 110-118 interleukin 6 Homo sapiens 97-101 1908551-7 1991 Using a variety of protein kinase activators and inhibitors, we have shown that the intracellular signalling pathways for both LIF and IL-6 are distinct from those of known second messengers and involve protein phosphorylation, notably tyrosine phosphorylation of a 160-kDa protein, as an essential step(s) in the immediate early activation of MyD gene expression. Tyrosine 236-244 interleukin 6 Homo sapiens 135-139 34290255-3 2021 Here, we show that cancer-associated fibroblast (CAF)-activated stromal signaling, interleukin-6/8-JAK2, induces BRD4 phosphorylation at tyrosine 97/98 in colorectal cancer, resulting in BRD4 stabilization due to interaction with the deubiquitinase UCHL3. Tyrosine 137-145 interleukin 6 Homo sapiens 83-98 34703823-8 2021 Furthermore, 15d-PGJ2 inhibited interleukin-6-induced tyrosine phosphorylation of STAT3 in LNCaP cells. Tyrosine 54-62 interleukin 6 Homo sapiens 32-45 2268669-2 1990 The homonuclear Hartmann-Hahn spectrum clearly shows all connectivities for the histidine, tyrosine and tryptophan residues that exist in IL-6. Tyrosine 91-99 interleukin 6 Homo sapiens 138-142 34687791-6 2022 Depletion of IL-6Ralpha abolished IL-6 induced STAT3 phosphorylation at 705th tyrosine and tumor growth of HCC cells under sorafenib treatment. Tyrosine 78-86 interleukin 6 Homo sapiens 34-38 34390807-4 2021 The two mutants displayed elevated levels of tyrosine phosphorylation, premature nuclear accumulation, and differential transcriptional responses following stimulation of cells with interleukin-6 and interferon-gamma. Tyrosine 45-53 interleukin 6 Homo sapiens 182-195 34536415-8 2022 RESULTS: Mutant HCK lacking the C-terminal inhibitory tyrosine Tyr522 exhibited increased kinase activity and enhanced myeloid cell priming, migration and effector functions, such as production of the inflammatory cytokines IL-1beta, IL-6, IL-8 and TNFalpha and production of reactive oxygen species. Tyrosine 54-62 interleukin 6 Homo sapiens 234-238 29807795-4 2018 CG-06 inhibited STAT3 phosphorylation at tyrosine 705 in a dose- and time dependent manner in DU-145 cells and suppressed IL-6-induced STAT3 phosphorylation at Tyr-705 in DU-145 and LNCaP cell lines. Tyrosine 160-163 interleukin 6 Homo sapiens 122-126 33382511-4 2021 STAT3 is rapidly and transiently activated by tyrosine phosphorylation by a range of signalling pathways, including cytokines from the IL-6 family and growth factors, such as EGF and PDGF. Tyrosine 46-54 interleukin 6 Homo sapiens 135-139 31068940-5 2019 In particular, we found that CD28-activated RelA/NF-kappaB induces the expression of IL-6 that, in a positive feedback loop, mediates the activation and nuclear translocation of tyrosine phosphorylated STAT3 (pSTAT3). Tyrosine 178-186 interleukin 6 Homo sapiens 85-89 31080186-11 2019 Mechanistically, FXT suppressed the IL-6-induced phosphorylation of tyrosine residue (Tyr705) of signal transducer and activator of transcription 3 (STAT3) probably by binding to STAT3. Tyrosine 68-76 interleukin 6 Homo sapiens 36-40 26572585-4 2015 EC overexpression of mutant ITGB4 with specific tyrosines mutated to phenylalanine (Y1440, Y1526 Y1640, or Y1422) resulted in significantly attenuated CS-induced cytokine expression (IL6, IL-8, MCP-1, and RANTES). Tyrosine 48-57 interleukin 6 Homo sapiens 183-186 28558479-3 2018 Recent Advances: Extracellular IL-6, which stimulates the release of cortisol from the zona fasciculata of the adrenal cortex, mediates its intracellular effects by tyrosine phosphorylation of the transcription factor signal transducer and activator of transcription 3 (STAT3). Tyrosine 165-173 interleukin 6 Homo sapiens 31-35 29456111-2 2018 Methyllucidone inhibited STAT3 phosphorylation at tyrosine 705 in a dose- and time dependent manner in DU145 prostate cancer cells and suppressed IL-6-induced STAT3 phosphorylation at Tyr-705 in LNCaP cells. Tyrosine 50-58 interleukin 6 Homo sapiens 146-150 29456111-2 2018 Methyllucidone inhibited STAT3 phosphorylation at tyrosine 705 in a dose- and time dependent manner in DU145 prostate cancer cells and suppressed IL-6-induced STAT3 phosphorylation at Tyr-705 in LNCaP cells. Tyrosine 184-187 interleukin 6 Homo sapiens 146-150 28722170-1 2017 In chronic lymphocytic leukemia (CLL) cells, both interleukin-6 (IL-6) and the B-cell receptor (BCR) activate Janus kinase 2 (JAK2) and induce the phosphorylation of signal transduction and activator of transcription 3 (STAT3) on tyrosine 705 residues. Tyrosine 230-238 interleukin 6 Homo sapiens 50-63 28722170-1 2017 In chronic lymphocytic leukemia (CLL) cells, both interleukin-6 (IL-6) and the B-cell receptor (BCR) activate Janus kinase 2 (JAK2) and induce the phosphorylation of signal transduction and activator of transcription 3 (STAT3) on tyrosine 705 residues. Tyrosine 230-238 interleukin 6 Homo sapiens 65-69 28722170-8 2017 The IgM-induced production of IL-6 prompted the phosphorylation of STAT3 on tyrosine residues. Tyrosine 76-84 interleukin 6 Homo sapiens 30-34 28208810-10 2017 Moreover, by using Shp2 phosphatase mutants, phosphor-tyrosine mimicking, and deficiency mutants, we provided evidence that the phosphatase activity of Shp2 and its tyrosine phosphorylation, are necessary for the IL-6-induced downregulation of E-cadherin and the phosphorylation of Erk1/2. Tyrosine 165-173 interleukin 6 Homo sapiens 213-217 27502766-6 2016 Immunoblot analyses demonstrated that Oncostatin M (OSM), a member of the interleukin-6 (IL-6) cytokine family, induced both P-STAT3 Tyr and P-STAT3 Ser in SH-SY5Y cells. Tyrosine 133-136 interleukin 6 Homo sapiens 89-93 27048653-6 2016 Importantly, small interfering RNA-mediated reduction of endogenous ARL3 expression decreased IL-6-induced tyrosine phosphorylation, nuclear accumulation, and transcriptional activity of STAT3. Tyrosine 107-115 interleukin 6 Homo sapiens 94-98 29660364-2 2018 Silibinin reduced IL-6 inducible, constitutive, and acquired feedback activation of STAT3 at tyrosine 705 (Y705). Tyrosine 93-101 interleukin 6 Homo sapiens 18-22 29581268-1 2018 In response to IFNbeta, the IL6 gene is activated, modestly at early times by ISGF3 (IRF9 plus tyrosine-phosphorylated STATs 1 and 2), and strongly at late times by U-ISGF3 (IRF9 plus U-STATs 1 and 2, lacking tyrosine phosphorylation). Tyrosine 95-103 interleukin 6 Homo sapiens 28-31 29581268-1 2018 In response to IFNbeta, the IL6 gene is activated, modestly at early times by ISGF3 (IRF9 plus tyrosine-phosphorylated STATs 1 and 2), and strongly at late times by U-ISGF3 (IRF9 plus U-STATs 1 and 2, lacking tyrosine phosphorylation). Tyrosine 209-217 interleukin 6 Homo sapiens 28-31 26893580-7 2016 RESULTS: In eight of nine ERalpha-positive breast cancer cell lines, recombinant IL-6 increased phosphorylation of tyrosine 705 of STAT3. Tyrosine 115-123 interleukin 6 Homo sapiens 81-85 26423306-8 2016 PHE/TYR was positively correlated with interleukin (IL)-1beta (r = 0.37, p = 0.011) and IL-6 (r = 0.33, p = 0.025). Tyrosine 4-7 interleukin 6 Homo sapiens 88-92 23906537-5 2013 We report for the first time that in addition to STAT3, Fer is required for IL-6 mediated AR activation by phosphorylating AR tyrosine 223 and binding via its SH2 domain. Tyrosine 126-134 interleukin 6 Homo sapiens 76-80 26384335-5 2015 In parallel to SOCS3 expression, IL-6 induced tyrosine phosphorylation of signal transducer and activator of transcription 3 (STAT3) in NS-1 cells. Tyrosine 46-54 interleukin 6 Homo sapiens 33-37 26384335-6 2015 Lentiviral delivery of short hairpin RNA (shSOCS3) (Lenti-shSOCS3) to decrease SOCS3 expression into NS-1 cells enhanced IL-6-induced tyrosine phosphorylation of STAT3 (P-STAT3 Tyr705) and promoted neurite outgrowth. Tyrosine 134-142 interleukin 6 Homo sapiens 121-125 26166037-9 2015 HHT reversiblely inhibited IL-6-induced STAT3 Tyrosine 705 phosphorylation and reduced anti-apoptotic proteins expression. Tyrosine 46-54 interleukin 6 Homo sapiens 27-31 23583378-4 2013 We found that IL-6-dependent induction of tyrosine phosphorylation and activation of STAT3 were influenced by nm23-H1 inhibition. Tyrosine 42-50 interleukin 6 Homo sapiens 14-18 24192293-5 2013 RESULTS: Expression of STAT3-YF-YFP impairs tyrosine phosphorylation, nuclear translocation and the transcriptional activity of WT-STAT3 in IL-6-stimulated cells. Tyrosine 44-52 interleukin 6 Homo sapiens 140-144 24082147-3 2013 SOCS3, the major negative regulator of STAT3, is induced by tyrosine-phosphorylated STAT3 and terminates STAT3 phosphorylation about 2 h after initial exposure of cells to members of the IL-6 family of cytokines by binding cooperatively to the common receptor subunit gp130 and JAKs 1 and 2. Tyrosine 60-68 interleukin 6 Homo sapiens 187-191 24152848-3 2013 IL-6R-alpha also exists as soluble protein (sIL-6R) that, in the presence of IL-6, forms a complex able to bind gp130 and, thanks to the mechanism called trans-signaling, transduces IL-6 effect through tyrosine phosphorylation and activation of the signal transducer and transcription activator (STAT)-3. Tyrosine 202-210 interleukin 6 Homo sapiens 0-4 24152848-3 2013 IL-6R-alpha also exists as soluble protein (sIL-6R) that, in the presence of IL-6, forms a complex able to bind gp130 and, thanks to the mechanism called trans-signaling, transduces IL-6 effect through tyrosine phosphorylation and activation of the signal transducer and transcription activator (STAT)-3. Tyrosine 202-210 interleukin 6 Homo sapiens 45-49 23166300-1 2013 Tyrosine phosphorylation-dependent signaling, as mediated by members of the epidermal growth factor receptor (EGFR) family (ErbB1 to -4) of protein tyrosine kinases (PTKs), Src family PTKs (SFKs), and cytokines such as interleukin-6 (IL-6) that signal via signal transducer and activator of transcription 3 (STAT3), is critical to the development and progression of many human breast cancers. Tyrosine 0-8 interleukin 6 Homo sapiens 219-232 23303450-3 2013 HSF showed increased Tyr 705 STAT3 phosphorylation compared with normal fibroblast (NF) after IL-6 IL-6Ralpha stimulation by immunoassays. Tyrosine 21-24 interleukin 6 Homo sapiens 0-3 23166300-1 2013 Tyrosine phosphorylation-dependent signaling, as mediated by members of the epidermal growth factor receptor (EGFR) family (ErbB1 to -4) of protein tyrosine kinases (PTKs), Src family PTKs (SFKs), and cytokines such as interleukin-6 (IL-6) that signal via signal transducer and activator of transcription 3 (STAT3), is critical to the development and progression of many human breast cancers. Tyrosine 0-8 interleukin 6 Homo sapiens 234-238 23032719-4 2013 We found that evodiamine suppressed both constitutive and interleukin-6 (IL-6)-induced activation of STAT3 tyrosine 705 (Tyr(705)) effectively. Tyrosine 107-115 interleukin 6 Homo sapiens 58-71 23032719-4 2013 We found that evodiamine suppressed both constitutive and interleukin-6 (IL-6)-induced activation of STAT3 tyrosine 705 (Tyr(705)) effectively. Tyrosine 107-115 interleukin 6 Homo sapiens 73-77 23032719-4 2013 We found that evodiamine suppressed both constitutive and interleukin-6 (IL-6)-induced activation of STAT3 tyrosine 705 (Tyr(705)) effectively. Tyrosine 121-124 interleukin 6 Homo sapiens 58-71 23032719-4 2013 We found that evodiamine suppressed both constitutive and interleukin-6 (IL-6)-induced activation of STAT3 tyrosine 705 (Tyr(705)) effectively. Tyrosine 121-124 interleukin 6 Homo sapiens 73-77 23032719-6 2013 Interestingly, treatment of cells with sodium pervanadate abrogated the inhibition of evodiamine on IL-6-induced STAT3 (Tyr(705)) activation indicating the involvement of protein tyrosine phosphatases. Tyrosine 120-123 interleukin 6 Homo sapiens 100-104 23032719-8 2013 Moreover, inhibition of SHP-1 gene by small interference RNA abolished the ability of evodiamine to inhibit IL-6-induced STAT3 (Tyr(705)) activation. Tyrosine 128-131 interleukin 6 Homo sapiens 108-112 23125416-8 2012 Neutralizing Ab to IL-6 inhibited CCL15-mediated STAT3 Tyr(705) phosphorylation, whereas inhibition of STAT3 activity abolished CCL15-activated CXCL8 release. Tyrosine 55-58 interleukin 6 Homo sapiens 19-23 21625522-2 2011 Cytokines such as interleukin-6 and interferon stimulate the specific tyrosine phosphorylation of STAT3, which confers its ability to bind consensus DNA targets. Tyrosine 70-78 interleukin 6 Homo sapiens 18-31 22197944-9 2012 EBLs from patients carrying the STAT3 "A" risk allele exhibited increased basal and IL-6-stimulated STAT3 tyrosine phosphorylation, increased transcription of STAT3 and SOCS3 after IL-6 stimulation, and increased membrane localization of the IL-6 receptor, GP130, and Janus-associated kinase 2. Tyrosine 106-114 interleukin 6 Homo sapiens 84-88 22280969-9 2012 Interleukin (IL)-6-induced phosphorylation of STAT3 at Tyr-705 was significantly blocked by DIM. Tyrosine 55-58 interleukin 6 Homo sapiens 0-18 21216930-6 2011 An interleukin-6 neutralizing antibody, siltuximab (CNTO 328) could inhibit STAT3 tyrosine phosphorylation in a cell-dependent manner. Tyrosine 82-90 interleukin 6 Homo sapiens 3-16 20978825-3 2011 In response to IL-6, the signal transducer and activator of transcription 3 (STAT3) becomes phosphorylated on tyrosine and serine residues. Tyrosine 110-118 interleukin 6 Homo sapiens 15-19 21954831-0 2012 Interleukin-6 autocrine signaling mediates melatonin MT(1/2) receptor-induced STAT3 Tyr(705) phosphorylation. Tyrosine 85-88 interleukin 6 Homo sapiens 0-13 21954831-7 2012 Antibody against IL-6, but not those for GM-CSF and CXCL-8, effectively abolished the agonist-induced STAT3 Tyr(705) phosphorylation, suggesting the involvement of IL-6 in melatonin receptor-mediated STAT3 activation. Tyrosine 108-111 interleukin 6 Homo sapiens 17-21 21690253-7 2011 This was associated with phosphorylation of tyrosine 705, a residue required for IL-6-induced STAT3 activation. Tyrosine 44-52 interleukin 6 Homo sapiens 81-85 21625597-2 2011 We report that, in human THP-1 cell line, they inhibit IL-6-elicited tyrosine phosphorylation of STAT3 and its DNA binding activity with EC(50) of 10 microM with concomitant down-regulation of the phosphorylation of the tyrosine Janus kinases JAK1, JAK2 and Tyk2. Tyrosine 69-77 interleukin 6 Homo sapiens 55-59 20876575-4 2010 We found that tyrosine 204 of the SOCS box, the SH2 domain, and the N-terminal kinase inhibitory region (KIR) of SOCS3 were all involved in its IL-6 inhibition. Tyrosine 14-22 interleukin 6 Homo sapiens 144-148 20728433-0 2010 Identification of BCAP-(L) as a negative regulator of the TLR signaling-induced production of IL-6 and IL-10 in macrophages by tyrosine phosphoproteomics. Tyrosine 127-135 interleukin 6 Homo sapiens 94-98 20693312-8 2010 Whereas IL-6 stimulated tyrosine phosphorylation of STAT3 in a time- and dose-dependent way, DXM and BTM had no effect on STAT3 phosphorylation. Tyrosine 24-32 interleukin 6 Homo sapiens 8-12 20379953-3 2010 Inhibition of MEK significantly blocked the effects of kansuinine A and B on IL-6-induced Stat3 activation and tyrosine phosphorylation. Tyrosine 111-119 interleukin 6 Homo sapiens 77-81 20724373-3 2010 The WA treatment (2 and 4 muM) decreased constitutive (MDA-MB-231) and/or IL-6-inducible (MDA-MB-231 and MCF-7) phosphorylation of STAT3 (Tyr(705)) and its upstream regulator Janus-activated kinase 2 (JAK2; Tyr(1007/1008)) in MDA-MB-231, which was accompanied by suppression of their protein levels especially at the higher concentration. Tyrosine 138-141 interleukin 6 Homo sapiens 74-78 20724373-3 2010 The WA treatment (2 and 4 muM) decreased constitutive (MDA-MB-231) and/or IL-6-inducible (MDA-MB-231 and MCF-7) phosphorylation of STAT3 (Tyr(705)) and its upstream regulator Janus-activated kinase 2 (JAK2; Tyr(1007/1008)) in MDA-MB-231, which was accompanied by suppression of their protein levels especially at the higher concentration. Tyrosine 207-210 interleukin 6 Homo sapiens 74-78 20383201-8 2010 Small interfering RNA-mediated knockdown of Ack1 or Src showed that Ack1 mediates heregulin- and Gas6-induced AR Tyr-267 phosphorylation, whereas Src mediates Tyr-534 phosphorylation induced by EGF, IL-6 and bombesin. Tyrosine 113-116 interleukin 6 Homo sapiens 199-203 20383201-7 2010 AR phosphorylation at Tyr-534 was induced by treatment with EGF, IL-6 or bombesin, but not by heregulin or Gas6. Tyrosine 22-25 interleukin 6 Homo sapiens 65-69 20383201-8 2010 Small interfering RNA-mediated knockdown of Ack1 or Src showed that Ack1 mediates heregulin- and Gas6-induced AR Tyr-267 phosphorylation, whereas Src mediates Tyr-534 phosphorylation induced by EGF, IL-6 and bombesin. Tyrosine 159-162 interleukin 6 Homo sapiens 199-203 19182994-4 2009 Interleukin-6 (IL-6)-induced phosphorylation of tyrosine-705 and serine-727, as well as DNA-binding and transcriptional activity of Stat3 were further enhanced by Ha-ras overexpression. Tyrosine 48-56 interleukin 6 Homo sapiens 0-13 20233902-4 2010 Growth-suppressive concentrations of SFN (20 and 40 micromol/L) decreased constitutive (DU145 cells) and IL-6-induced (DU145 and LNCaP cells) phosphorylation of STAT3 (Tyr(705)) as well as its upstream regulator Janus-activated kinase 2 (Tyr(1007/1008)). Tyrosine 168-171 interleukin 6 Homo sapiens 105-109 20233902-4 2010 Growth-suppressive concentrations of SFN (20 and 40 micromol/L) decreased constitutive (DU145 cells) and IL-6-induced (DU145 and LNCaP cells) phosphorylation of STAT3 (Tyr(705)) as well as its upstream regulator Janus-activated kinase 2 (Tyr(1007/1008)). Tyrosine 238-241 interleukin 6 Homo sapiens 105-109 19009233-6 2009 In addition, trichodimerol blocked IFN-gamma, IL-6 and IL-4 induced activation of Stat1, Stat3 and Stat6 transcription factors by inhibiting serine and tyrosine phosphorylation. Tyrosine 152-160 interleukin 6 Homo sapiens 46-50 20851386-6 2010 Western blot analysis of STAT3 phosphorylation showed that this augmented response in HT-29 cells following IL-10 neutralization is probably mediated through enhanced IL-6-induced phosphorylation (Tyr(705)) of STAT3 proteins. Tyrosine 197-200 interleukin 6 Homo sapiens 167-171 18988672-5 2009 Under these conditions there was a marked reduction in IL-6-dependent STAT3 signaling, including decreased STAT3 tyrosine phosphorylation, loss in nuclear accumulation of STAT3, and impaired expression of target genes, such as fibrinogen-gamma. Tyrosine 113-121 interleukin 6 Homo sapiens 55-59 19182994-4 2009 Interleukin-6 (IL-6)-induced phosphorylation of tyrosine-705 and serine-727, as well as DNA-binding and transcriptional activity of Stat3 were further enhanced by Ha-ras overexpression. Tyrosine 48-56 interleukin 6 Homo sapiens 15-19 18593565-2 2008 CD95L-induced caspase activation leads to degradation of gp130, thereby suppressing IL-6-induced phosphorylation of STAT3 (Tyr(705)) and of tyrosine phosphatase SHP2 (Tyr(580)). Tyrosine 123-126 interleukin 6 Homo sapiens 84-88 19274102-3 2009 Three compounds satisfied criteria of interaction analysis, competitively inhibited recombinant Stat3 binding to its immobilized pY-peptide ligand and inhibited IL-6-mediated tyrosine phosphorylation of Stat3. Tyrosine 175-183 interleukin 6 Homo sapiens 161-165 19967068-2 2008 In the present study, we found that specific tyrphostin inhibitors of ErbB2 (AG825 and AG879), but not ErbB1 inhibitor (AG1478), suppressed IL-6-induced tyrosine phosphorylation of STAT3 in schwannoma cells. Tyrosine 153-161 interleukin 6 Homo sapiens 140-144 19201396-4 2009 Western blotting analysis using monoclonal antibody against IL-6 or gp 130 verified that this IL-6-driven activity was through the activation of tyrosine phosphorylation (Tyr(705)) of STAT3 in cancer cells. Tyrosine 145-153 interleukin 6 Homo sapiens 60-64 19201396-4 2009 Western blotting analysis using monoclonal antibody against IL-6 or gp 130 verified that this IL-6-driven activity was through the activation of tyrosine phosphorylation (Tyr(705)) of STAT3 in cancer cells. Tyrosine 145-153 interleukin 6 Homo sapiens 94-98 19201396-4 2009 Western blotting analysis using monoclonal antibody against IL-6 or gp 130 verified that this IL-6-driven activity was through the activation of tyrosine phosphorylation (Tyr(705)) of STAT3 in cancer cells. Tyrosine 171-174 interleukin 6 Homo sapiens 60-64 19201396-4 2009 Western blotting analysis using monoclonal antibody against IL-6 or gp 130 verified that this IL-6-driven activity was through the activation of tyrosine phosphorylation (Tyr(705)) of STAT3 in cancer cells. Tyrosine 171-174 interleukin 6 Homo sapiens 94-98 18593565-2 2008 CD95L-induced caspase activation leads to degradation of gp130, thereby suppressing IL-6-induced phosphorylation of STAT3 (Tyr(705)) and of tyrosine phosphatase SHP2 (Tyr(580)). Tyrosine 167-170 interleukin 6 Homo sapiens 84-88 18544087-9 2008 We further examined the effect of CTD on the IL-6 signaling pathway in myeloma cells, and found that CTD inhibited phosphorylation of STAT3 at tyrosine 705 residue as early as 1 h after treatment and down-regulated the expression of the antiapoptotic bcl-xL protein. Tyrosine 143-151 interleukin 6 Homo sapiens 45-49 17956865-3 2007 IL-6 induces rapid nuclear translocation of Tyr-phosphorylated STAT3 that forms a nuclear complex with CDK9 in nondenaturing co-immunoprecipitation and confocal colocalization assays. Tyrosine 44-47 interleukin 6 Homo sapiens 0-4 18503751-5 2008 Importantly, small-interfering RNA-mediated reduction of endogenous Y14 expression decreased IL-6-induced tyrosine-phosphorylation, nuclear accumulation, and DNA-binding activity of STAT3, as well as IL-6/STAT3-dependent gene expression. Tyrosine 106-114 interleukin 6 Homo sapiens 93-97 18204781-4 2008 Treatment of cells with interleukin-6 neutralizing antibody inhibited the phosphorylation of STAT3 Tyr 705 and Ser 727. Tyrosine 99-102 interleukin 6 Homo sapiens 24-37 17823310-5 2007 We demonstrate that IL-6 induces the phosphorylation of the C-terminal tyrosine residue of the HGAL protein via the Lyn kinase, and promotes its relocalization from the cytoplasm to podosome-like structures. Tyrosine 71-79 interleukin 6 Homo sapiens 20-24 17258468-8 2006 Inhibition of tyrosine/serine phosphorylation mediated by MAPKs of STAT1 and STAT3 decrease the IL-6 secretion following porin stimulation. Tyrosine 14-22 interleukin 6 Homo sapiens 96-100 17716862-2 2007 IL-6 initiates its action by binding to its cell surface receptor, followed by activation of Janus kinases and tyrosine phosphorylation of the signal transducer and transcription factor (STAT) 3. Tyrosine 111-119 interleukin 6 Homo sapiens 0-4 17716862-4 2007 Here we show that pretreatment of HepG2 hepatoma cells with methyl-beta-cyclodextrin (MbetaCD), which removes cholesterol and destroys lipid rafts, inhibited tyrosine phosphorylation of STAT3 in IL-6-activated, but not PV-activated cells. Tyrosine 158-166 interleukin 6 Homo sapiens 195-199 17716862-7 2007 The extent of IL-6-induced tyrosine phosphorylation of STAT3 was comparable in cells expressing low or high levels of caveolin. Tyrosine 27-35 interleukin 6 Homo sapiens 14-18 17510282-1 2007 gp130-linked cytokines such as interleukin-6 (IL-6) stimulate the formation of tyrosine-phosphorylated signal transducer and activator of transcription 3 (P-STAT3), which activates many genes, including the STAT3 gene itself. Tyrosine 79-87 interleukin 6 Homo sapiens 31-44 17510282-1 2007 gp130-linked cytokines such as interleukin-6 (IL-6) stimulate the formation of tyrosine-phosphorylated signal transducer and activator of transcription 3 (P-STAT3), which activates many genes, including the STAT3 gene itself. Tyrosine 79-87 interleukin 6 Homo sapiens 46-50 17242212-5 2007 In addition, IL-6 treatment resulted in impaired IRS-1 phosphorylation at Tyr(612), a site essential for engaging PI3-kinase. Tyrosine 74-77 interleukin 6 Homo sapiens 13-17 17531096-0 2007 Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer. Tyrosine 9-17 interleukin 6 Homo sapiens 45-58 16407171-3 2006 By 15-30 min after interleukin-6 (IL-6) treatment, up to two-thirds of cytoplasmic Tyr-phosphorylated STAT3 can be associated with the purified early endosome fraction (Rab-5-, EEA1-, transferrin receptor-, and clathrin-positive fraction). Tyrosine 83-86 interleukin 6 Homo sapiens 34-38 16926159-3 2006 Here we show that treatment of cultured HepG2 hepatoma cells with PDTC inhibits IL-6-stimulated tyrosine phosphorylation and subsequent nuclear translocation of STAT3 in a dose- and time-dependent fashion. Tyrosine 96-104 interleukin 6 Homo sapiens 80-84 15894558-5 2005 In this study, we show that IL-6 stimulates a transient increase of tyrosine phosphorylation of STAT3 in a dose-dependent fashion. Tyrosine 68-76 interleukin 6 Homo sapiens 28-32 16086584-10 2005 Finally, MadA, but not the HFI portion, inhibits IL-6-dependent Stat3 tyrosine phosphorylation in HepG2 cells. Tyrosine 70-78 interleukin 6 Homo sapiens 49-53