Tyrosine

insulin receptor substrate 1 ; Homo sapiens







424 Article(s)
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51 23190749 Kakkalide ameliorates endothelial insulin resistance by suppressing reactive oxygen species-associated inflammation. 2013 Mar 1
52 23274913 Overexpression of TFAM protects 3T3-L1 adipocytes from NYGGF4 (PID1) overexpression-induced insulin resistance and mitochondrial dysfunction. 2013 Jul 2
53 23404947 Chronic leucine supplementation increases body weight and insulin sensitivity in rats on high-fat diet likely by promoting insulin signaling in insulin-target tissues. 2013 Jun 1
54 23460259 GRK2 negatively regulates IGF-1R signaling pathway and cyclins' expression in HepG2 cells. 2013 Sep 1
55 23463119 Diabetes and infections-hepatitis C: is there type 2 diabetes excess in hepatitis C infection? 2013 Jun 1
56 23478262 The AP-1 complex regulates intracellular localization of insulin receptor substrate 1, which is required for insulin-like growth factor I-dependent cell proliferation. 2013 May 2
57 23481042 Platelet-derived growth factor negatively regulates the insulin-like growth factor signaling pathway through the coordinated action of phosphatidylinositol 3-kinase and protein kinase C beta I. 2013 Jun 1
58 23504962 Quercetin and quercetin-3-O-glucuronide are equally effective in ameliorating endothelial insulin resistance through inhibition of reactive oxygen species-associated inflammation. 2013 Jun 1
59 23565163 Phosphorylation of IRS1 at serine 307 in response to insulin in human adipocytes is not likely to be catalyzed by p70 ribosomal S6 kinase. 2013 2
60 23566306 Fructose-induced stress signaling in the liver involves methylglyoxal. 2013 1
61 23831466 Pinusolide improves high glucose-induced insulin resistance via activation of AMP-activated protein kinase. 2013 Aug 2 2
62 23983791 Naringenin inhibits adipogenesis and reduces insulin sensitivity and adiponectin expression in adipocytes. 2013 1
63 21804605 A tripartite complex composed of ETV6-NTRK3, IRS1 and IGF1R is required for ETV6-NTRK3-mediated membrane localization and transformation. 2012 Mar 8 3
64 22006247 Endoplasmic reticulum stress does not mediate palmitate-induced insulin resistance in mouse and human muscle cells. 2012 Jan 2
65 22028447 Heparin-binding EGF-like growth factor (HB-EGF) mediates 5-HT-induced insulin resistance through activation of EGF receptor-ERK1/2-mTOR pathway. 2012 Jan 2
66 22158866 Inhibition of insulin signaling in endothelial cells by protein kinase C-induced phosphorylation of p85 subunit of phosphatidylinositol 3-kinase (PI3K). 2012 Feb 10 2
67 22207502 Phosphorylation of the insulin receptor by AMP-activated protein kinase (AMPK) promotes ligand-independent activation of the insulin signalling pathway in rodent muscle. 2012 Mar 1
68 22227580 Phosphatidylinositol 3-kinase and protein kinase D1 specifically cooperate to negatively regulate the insulin-like growth factor signaling pathway. 2012 Feb 4
69 22281494 Improved insulin sensitivity by rapamycin is associated with reduction of mTOR and S6K1 activities in L6 myotubes. 2012 Feb 10 2
70 22355071 Regulation of glucose transport by ROCK1 differs from that of ROCK2 and is controlled by actin polymerization. 2012 Apr 1
71 22528396 α-Lipoic acid protects 3T3-L1 adipocytes from NYGGF4 (PID1) overexpression-induced insulin resistance through increasing phosphorylation of IRS-1 and Akt. 2012 Jun 1
72 22609131 From excess adiposity to insulin resistance: the role of free fatty acids. 2012 Sep-Oct 1
73 22629383 Soluble and cell-associated insulin receptor dysfunction correlates with severity of HAND in HIV-infected women. 2012 1
74 22728334 Protein phosphatase 1 regulatory subunit 12A and catalytic subunit δ, new members in the phosphatidylinositide 3 kinase insulin-signaling pathway. 2012 Sep 2
75 22766331 Diosgenin ameliorates palmitate-induced endothelial dysfunction and insulin resistance via blocking IKKβ and IRS-1 pathways. 2012 Aug 2
76 22820890 α-Lipoic acid ameliorates impaired glucose uptake in LYRM1 overexpressing 3T3-L1 adipocytes through the IRS-1/Akt signaling pathway. 2012 Oct 1
77 22968630 NYGGF4 (PID1) effects on insulin resistance are reversed by metformin in 3T3-L1 adipocytes. 2012 Dec 1
78 23045700 PKA and GAB2 play central roles in the FSH signaling pathway to PI3K and AKT in ovarian granulosa cells. 2012 Oct 30 2
79 23073384 Transcriptome correlation analysis identifies two unique craniosynostosis subtypes associated with IRS1 activation. 2012 Dec 1 1
80 23182460 NOD1 activation induces innate immune responses and insulin resistance in human adipocytes. 2012 Dec 1
81 20594757 mTOR partly mediates insulin resistance by phosphorylation of insulin receptor substrate-1 on serine(307) residues after burn. 2011 Feb 1
82 21168390 Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases. 2011 Jan 21 4
83 21189360 In vivo activation of ROCK1 by insulin is impaired in skeletal muscle of humans with type 2 diabetes. 2011 Mar 1
84 21289241 Chronically increased S6K1 is associated with impaired IRS1 signaling in skeletal muscle of GDM women with impaired glucose tolerance postpartum. 2011 May 1
85 21321112 An early response transcription factor, Egr-1, enhances insulin resistance in type 2 diabetes with chronic hyperinsulinism. 2011 Apr 22 1
86 21386060 Both type I and II IFN induce insulin resistance by inducing different isoforms of SOCS expression in 3T3-L1 adipocytes. 2011 Jun 3
87 21664164 Effect of NF-κB decoy on insulin resistance of adipocytes from patients with type 2 diabetes mellitus. 2011 Dec 2
88 21786209 Betel nut extract and arecoline block insulin signaling and lipid storage in 3T3-L1 adipocytes. 2011 Dec 1
89 21937042 Angiotensin II type 1 receptor, but no type 2 receptor, interferes with the insulin-induced nitric oxide production in HUVECs. 2011 Dec 1
90 19636223 Effect of short hairpin RNA-mediated adiponectin/Acrp30 down-regulation on insulin signaling and glucose uptake in the 3T3-L1 adipocytes. 2010 Feb 2
91 19782747 TNFalpha activation of PKCdelta, mediated by NFkappaB and ER stress, cross-talks with the insulin signaling cascade. 2010 Feb 1
92 19952103 The regulatory domain of protein kinase C delta positively regulates insulin receptor signaling. 2010 Mar 1
93 20018868 Regulation of insulin receptor substrate 1 (IRS-1)/AKT kinase-mediated insulin signaling by O-Linked beta-N-acetylglucosamine in 3T3-L1 adipocytes. 2010 Feb 19 1
94 20060191 The effect of mosapride (5HT-4 receptor agonist) on insulin sensitivity and GLUT4 translocation. 2010 Mar 2
95 20071559 Progesterone inhibits glucose uptake by affecting diverse steps of insulin signaling in 3T3-L1 adipocytes. 2010 Apr 1
96 20185348 IGF-I stimulates reactive oxygen species (ROS) production and inhibits insulin-dependent glucose uptake via ROS in 3T3-L1 adipocytes. 2010 Jun 2
97 20208423 S-Adenosyl-L-methionine ameliorates TNFalpha-induced insulin resistance in 3T3-L1 adipocytes. 2010 May 31 2
98 20363874 AMP-activated protein kinase inhibits IGF-I signaling and protein synthesis in vascular smooth muscle cells via stimulation of insulin receptor substrate 1 S794 and tuberous sclerosis 2 S1345 phosphorylation. 2010 Jun 4
99 20383171 Berberine reduces endoplasmic reticulum stress and improves insulin signal transduction in Hep G2 cells. 2010 May 1
100 20594869 Label-free relative quantification of co-eluting isobaric phosphopeptides of insulin receptor substrate-1 by HPLC-ESI-MS/MS. 2010 Sep 2