Title : Platelet-derived growth factor negatively regulates the insulin-like growth factor signaling pathway through the coordinated action of phosphatidylinositol 3-kinase and protein kinase C beta I.

Pub. Date : 2013 Jun

PMID : 23481042






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 PDGF inhibited IGF-I-stimulated IRS-1 tyrosine phosphorylation and subsequent IGF-I-induced PI 3-kinase activity, and stimulated IRS-1 serine 307 phosphorylation. Tyrosine insulin receptor substrate 1 Homo sapiens