Title : Angiotensin II type 1 receptor, but no type 2 receptor, interferes with the insulin-induced nitric oxide production in HUVECs.

Pub. Date : 2011 Dec

PMID : 21937042






1 Functional Relationships(s)
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1 RESULTS: ATII induces IRS-1 phosphorylation at Ser(312) and Ser(616) through the activation of JNK and ERK 1/2, resulting in the inhibition of the insulin-induced phosphorylation of IRS1 tyrosines, Akt and eNOS. Tyrosine insulin receptor substrate 1 Homo sapiens