Title : Pinusolide improves high glucose-induced insulin resistance via activation of AMP-activated protein kinase.

Pub. Date : 2013 Aug 2

PMID : 23831466






2 Functional Relationships(s)
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1 An insulin resistance state was induced by exposing cells to 30mM glucose, as indicated by reduced insulin-stimulated tyrosine phosphorylation of IRS-1 and glucose uptake. Tyrosine insulin receptor substrate 1 Homo sapiens
2 Taken together, our findings suggest a link between high glucose and insulin resistance in muscle cells, and provide further evidence that pinusolide attenuates blockade of insulin signaling by enhancing IRS-1 tyrosine phosphorylation by the activating the AMPK pathway. Tyrosine insulin receptor substrate 1 Homo sapiens