Title : Effect of NF-κB decoy on insulin resistance of adipocytes from patients with type 2 diabetes mellitus.

Pub. Date : 2011 Dec

PMID : 21664164






2 Functional Relationships(s)
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1 RESULTS: Compared with cells from non-diabetic subjects, adipocytes from T2DM patients showed signs of insulin resistance, with significantly reduced IRS-1 tyrosine and AKT (Ser 473) phosphorylation levels in response to insulin stimulation. Tyrosine insulin receptor substrate 1 Homo sapiens
2 Introduction of NF-kappaB decoy molecules significantly inhibited both IL-6 secretion and NF-kappaB activity, while enhancing insulin-stimulated IRS-1 tyrosine and AKT (Ser473) phosphorylation in T2DM adipocytes. Tyrosine insulin receptor substrate 1 Homo sapiens