| 1 |
34665271 | Inhibitors of class I HDACs and of FLT3 combine synergistically against leukemia cells with mutant FLT3. | 2022 Jan |
1 |
| 2 |
34289383 | Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells. | 2021 Sep 16 |
1 |
| 3 |
31821677 | FLT3 mutations in acute myeloid leukemia: Therapeutic paradigm beyond inhibitor development. | 2020 Feb |
2 |
| 4 |
31872224 | Monocytic Maturation Induced by FLT3 Inhibitor Therapy of Acute Myeloid Leukemia: Morphologic and Immunophenotypic Characteristics. | 2020 Sep 1 |
1 |
| 5 |
31919472 | FLT3 inhibitors in acute myeloid leukemia: ten frequently asked questions. | 2020 Mar |
2 |
| 6 |
32015510 | Inhibition of the deubiquitinase USP10 induces degradation of SYK. | 2020 Apr |
4 |
| 7 |
32021432 | Profile of Quizartinib for the Treatment of Adult Patients with Relapsed/Refractory FLT3-ITD-Positive Acute Myeloid Leukemia: Evidence to Date. | 2020 |
1 |
| 8 |
32040554 | Gilteritinib is a clinically active FLT3 inhibitor with broad activity against FLT3 kinase domain mutations. | 2020 Feb 11 |
3 |
| 9 |
30552988 | The role of SRC family kinases in FLT3 signaling. | 2019 Feb |
1 |
| 10 |
30553232 | Fms-like tyrosine kinase 3 is a key factor of male fertility. | 2019 Mar 1 |
1 |
| 11 |
30946869 | Inhibition of USP9X induces apoptosis in FLT3-ITD-positive AML cells cooperatively by inhibiting the mutant kinase through aggresomal translocation and inducing oxidative stress. | 2019 Jul 1 |
1 |
| 12 |
31066629 | FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications. | 2019 Jul 1 |
2 |
| 13 |
31395602 | Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL-rearranged acute lymphoblastic leukemia. | 2019 Oct 10 |
1 |
| 14 |
31721578 | Identification of a Multitargeted Tyrosine Kinase Inhibitor for the Treatment of Gastrointestinal Stromal Tumors and Acute Myeloid Leukemia. | 2019 Dec 26 |
2 |
| 15 |
31751472 | LAM-003, a new drug for treatment of tyrosine kinase inhibitor-resistant FLT3-ITD-positive AML. | 2019 Nov 26 |
2 |
| 16 |
31756944 | FLT3-ITD Activates RSK1 to Enhance Proliferation and Survival of AML Cells by Activating mTORC1 and eIF4B Cooperatively with PIM or PI3K and by Inhibiting Bad and BIM. | 2019 Nov 20 |
1 |
| 17 |
31779982 | Beyond midostaurin: Which are the most promising FLT3 inhibitors in AML? | 2019 Dec |
1 |
| 18 |
31790499 | Expression of myeloid Src-family kinases is associated with poor prognosis in AML and influences Flt3-ITD kinase inhibitor acquired resistance. | 2019 |
1 |
| 19 |
31807186 | Prognosis and outcome of patients with acute myeloid leukemia based on FLT3-ITD mutation with or without additional abnormal cytogenetics. | 2019 Dec |
1 |
| 20 |
31861239 | A Novel Inhibitor of STAT5 Signaling Overcomes Chemotherapy Resistance in Myeloid Leukemia Cells. | 2019 Dec 17 |
1 |
| 21 |
28522571 | FLT3 and FLT3-ITD phosphorylate and inactivate the cyclin-dependent kinase inhibitor p27Kip1 in acute myeloid leukemia. | 2017 Aug |
5 |
| 22 |
26852660 | Immunophenotyping with CD135 and CD117 predicts the FLT3, IL-7R and TLX3 gene mutations in childhood T-cell acute leukemia. | 2016 Mar |
2 |
| 23 |
27458164 | Src-like adaptor protein 2 (SLAP2) binds to and inhibits FLT3 signaling. | 2016 Sep 6 |
2 |
| 24 |
24608088 | Activating FLT3 mutants show distinct gain-of-function phenotypes in vitro and a characteristic signaling pathway profile associated with prognosis in acute myeloid leukemia. | 2014 |
2 |
| 25 |
23009217 | FLT3-driven redox-modulation of Ezrin regulates leukaemic cell migration. | 2013 Jan |
1 |
| 26 |
23246379 | FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia. | 2013 Jun |
3 |
| 27 |
24040307 | Pim-1 kinase phosphorylates and stabilizes 130 kDa FLT3 and promotes aberrant STAT5 signaling in acute myeloid leukemia with FLT3 internal tandem duplication. | 2013 |
2 |
| 28 |
24255108 | FLT3/D835Y mutation knock-in mice display less aggressive disease compared with FLT3/internal tandem duplication (ITD) mice. | 2013 Dec 24 |
2 |
| 29 |
21881825 | 3,4-Diarylmaleimides-a novel class of kinase inhibitors-effectively induce apoptosis in FLT3-ITD-dependent cells. | 2012 Mar |
1 |
| 30 |
22084166 | Induction of vascular endothelial growth factor secretion by childhood acute lymphoblastic leukemia cells via the FLT-3 signaling pathway. | 2012 Jan |
4 |
| 31 |
22126602 | Y654 of β-catenin is essential for FLT3/ITD-related tyrosine phosphorylation and nuclear localization of β-catenin. | 2012 Apr |
5 |
| 32 |
22411868 | SRC is a signaling mediator in FLT3-ITD- but not in FLT3-TKD-positive AML. | 2012 Apr 26 |
1 |
| 33 |
22952242 | Suppressor of cytokine signaling 6 (SOCS6) negatively regulates Flt3 signal transduction through direct binding to phosphorylated tyrosines 591 and 919 of Flt3. | 2012 Oct 19 |
3 |
| 34 |
21552520 | Survey of activated FLT3 signaling in leukemia. | 2011 Apr 28 |
2 |
| 35 |
20508617 | Ubiquitin conjugase UBCH8 targets active FMS-like tyrosine kinase 3 for proteasomal degradation. | 2010 Aug |
2 |
| 36 |
19477218 | Oncogenic Flt3 receptors display different specificity and kinetics of autophosphorylation. | 2009 Aug |
3 |
| 37 |
18628457 | Transformation by oncogenic mutants and ligand-dependent activation of FLT3 wild-type requires the tyrosine residues 589 and 591. | 2008 Jul 15 |
9 |
| 38 |
17668209 | Src family tyrosine kinases phosphorylate Flt3 on juxtamembrane tyrosines and interfere with receptor maturation in a kinase-dependent manner. | 2007 Nov |
1 |
| 39 |
17851558 | FLT3 regulates beta-catenin tyrosine phosphorylation, nuclear localization, and transcriptional activity in acute myeloid leukemia cells. | 2007 Dec |
6 |
| 40 |
16684964 | Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2. | 2006 Sep 1 |
1 |
| 41 |
15345593 | Identification of a novel activating mutation (Y842C) within the activation loop of FLT3 in patients with acute myeloid leukemia (AML). | 2005 Jan 1 |
1 |
| 42 |
16250847 | FLT3 and acute myelogenous leukemia: biology, clinical significance and therapeutic applications. | 2005 |
1 |
| 43 |
12529667 | Better detection of FLT3 internal tandem duplication using peripheral blood plasma DNA. | 2003 Jan |
1 |
| 44 |
12796379 | Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells. | 2003 Jun |
2 |
| 45 |
10720129 | In vivo treatment of mutant FLT3-transformed murine leukemia with a tyrosine kinase inhibitor. | 2000 Mar |
1 |
| 46 |
11027663 | Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase. | 2000 Oct 14 |
3 |
| 47 |
9918857 | p85 subunit of PI3 kinase does not bind to human Flt3 receptor, but associates with SHP2, SHIP, and a tyrosine-phosphorylated 100-kDa protein in Flt3 ligand-stimulated hematopoietic cells. | 1999 Jan 19 |
1 |
| 48 |
10080542 | Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells. | 1999 Mar |
1 |
| 49 |
9529123 | FLT3 signaling in hematopoietic cells involves CBL, SHC and an unknown P115 as prominent tyrosine-phosphorylated substrates. | 1998 Mar |
1 |
| 50 |
9276617 | Characterization of two different cytoplasmic protein tyrosine kinases from human breast cancer. | 1997 Aug |
1 |