Title : Metformin attenuates hyperalgesia and allodynia in rats with painful diabetic neuropathy induced by streptozotocin.

Pub. Date : 2015 Oct 5

PMID : 26054810






3 Functional Relationships(s)
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1 Further studies showed that metformin could activate AMPK and increase the AMPK target genes in sciatic nerves in diabetic rats. Metformin protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus
2 Further studies showed that metformin could activate AMPK and increase the AMPK target genes in sciatic nerves in diabetic rats. Metformin protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus
3 In conclusion, metformin is able to attenuate diabetes-induced hyperalgesia and allodynia, which might be associated its anti-oxidative effect through AMPK pathway. Metformin protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus