Title : Metformin inhibits nuclear factor-κB activation and inflammatory cytokines expression induced by high glucose via adenosine monophosphate-activated protein kinase activation in rat glomerular mesangial cells in vitro.

Pub. Date : 2014

PMID : 24791887






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 BACKGROUND: The renoprotective mechanisms of adenosine monophosphate (AMP)-activated protein kinase (AMPK) agonist - metformin have not been stated clearly. Metformin protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus
2 We hypothesized that metformin may ameliorate inflammation via AMPK interaction with critical inflammatory cytokines. Metformin protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus
3 The expression of p-AMPK increased with the rising of metformin concentration, presenting the opposite trend, while the level of total-AMPK protein was unchanged with exposure to HG or metformin. Metformin protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus
4 Conlusion Metformin can suppress the expression of NF-kappaB, MCP-1, ICAM-1 and TGF-beta1 of glomerular MCs induced by high glucose via AMPK activation, which may partly contribute to its reno-protection. Metformin protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus