| 1 |
35078048 | Discovery of (E)-4-styrylphenoxy-propanamide: A dual PPARα/γ partial agonist that regulates high-density lipoprotein-cholesterol levels, modulates adipogenesis, and improves glucose tolerance in diet-induced obese mice. | 2022 Mar |
1 |
| 2 |
35150895 | Enterocyte-specific ATGL overexpression affects intestinal and systemic cholesterol homeostasis. | 2022 Apr |
1 |
| 3 |
35184357 | Targeted inhibition of PPARα ameliorates CLA-induced hypercholesterolemia via hepatic cholesterol biosynthesis reprogramming. | 2022 Jun |
1 |
| 4 |
33996254 | HFD-induced TRAF6 upregulation promotes liver cholesterol accumulation and fatty liver development via EZH2-mediated miR-429/PPARα axis. | 2021 Jun 4 |
2 |
| 5 |
32176696 | The PPAR pan-agonist tetradecylthioacetic acid promotes redistribution of plasma cholesterol towards large HDL. | 2020 |
1 |
| 6 |
32584895 | A novel selective PPARα modulator, pemafibrate promotes ischemia-induced revascularization through the eNOS-dependent mechanisms. | 2020 |
1 |
| 7 |
32661772 | NPC1L1 and ABCG5/8 induction explain synergistic fecal cholesterol excretion in ob/ob mice co-treated with PPAR-α and LXR agonists. | 2020 Oct |
8 |
| 8 |
32687853 | Novel Mechanism of Cholesterol Transport by ABCA5 in Macrophages and Its Role in Dyslipidemia. | 2020 Aug 7 |
2 |
| 9 |
32822737 | Perfluorooctanoic acid activates multiple nuclear receptor pathways and skews expression of genes regulating cholesterol homeostasis in liver of humanized PPARα mice fed an American diet. | 2020 Oct 15 |
1 |
| 10 |
30341732 | Peroxisome proliferator-activated receptor α attenuates high-cholesterol diet-induced toxicity and pro-thrombotic effects in mice. | 2019 Jan |
3 |
| 11 |
30504232 | Hepatic transcriptome analysis from HFD-fed mice defines a long noncoding RNA regulating cellular cholesterol levels. | 2019 Feb |
1 |
| 12 |
30592221 | Hypocholesterolemic Effect of the Lignin-Rich Insoluble Residue of Brewer's Spent Grain in Mice Fed a High-Fat Diet. | 2019 Jan 30 |
1 |
| 13 |
30957417 | Resveratrol inhibits lipid accumulation in the intestine of atherosclerotic mice and macrophages. | 2019 Jun |
3 |
| 14 |
31055081 | Astaxanthin exerts protective effects similar to bexarotene in Alzheimer's disease by modulating amyloid-beta and cholesterol homeostasis in blood-brain barrier endothelial cells. | 2019 Sep 1 |
1 |
| 15 |
31607484 | Fenofibrate induces PPARα and BMP2 expression to stimulate osteoblast differentiation. | 2019 Dec 3 |
1 |
| 16 |
31654746 | Transcriptome analysis reveals that cyclophosphamide induces premature ovarian failure by blocking cholesterol biosynthesis pathway. | 2019 Dec 15 |
1 |
| 17 |
31851938 | SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα. | 2019 Dec 17 |
1 |
| 18 |
31933883 | Abnormality of intestinal cholesterol absorption in ApcMin/+ mice with colon cancer cachexia. | 2019 |
2 |
| 19 |
29112762 | Alteration of Bile Acid and Cholesterol Biosynthesis and Transport by Perfluorononanoic Acid (PFNA) in Mice. | 2018 Mar 1 |
1 |
| 20 |
29352300 | 5-aminosalicylic acid improves lipid profile in mice fed a high-fat cholesterol diet through its dual effects on intestinal PPARγ and PPARα. | 2018 |
1 |
| 21 |
29960113 | The olive constituent oleuropein, as a PPARα agonist, markedly reduces serum triglycerides. | 2018 Sep |
1 |
| 22 |
30001434 | Retraction: 5-aminosalicylic acid improves lipid profile in mice fed a high-fat cholesterol diet through its dual effects on intestinal PPARγ and PPARα. | 2018 |
1 |
| 23 |
30271349 | Lack of Correlation of Plasma HDL With Fecal Cholesterol and Plasma Cholesterol Efflux Capacity Suggests Importance of HDL Functionality in Attenuation of Atherosclerosis. | 2018 |
5 |
| 24 |
28082284 | Hepatocyte-specific PPARA expression exclusively promotes agonist-induced cell proliferation without influence from nonparenchymal cells. | 2017 Mar 1 |
1 |
| 25 |
28855656 | PPARα-dependent Insig2a overexpression inhibits SREBP-1c processing during fasting. | 2017 Aug 30 |
2 |
| 26 |
26838045 | PPARα-dependent cholesterol/testosterone disruption in Leydig cells mediates 2,4-dichlorophenoxyacetic acid-induced testicular toxicity in mice. | 2016 Dec |
2 |
| 27 |
27229177 | NAMPT knockdown attenuates atherosclerosis and promotes reverse cholesterol transport in ApoE KO mice with high-fat-induced insulin resistance. | 2016 May 27 |
1 |
| 28 |
23220585 | Adipose triglyceride lipase is a TG hydrolase of the small intestine and regulates intestinal PPARα signaling. | 2013 Feb |
1 |
| 29 |
23967086 | Role of PPARα and HNF4α in stress-mediated alterations in lipid homeostasis. | 2013 |
1 |
| 30 |
22098164 | Inflammatory stress exacerbates hepatic cholesterol accumulation via disrupting cellular cholesterol export. | 2012 May |
1 |
| 31 |
22207087 | Influence of depleted uranium on hepatic cholesterol metabolism in apolipoprotein E-deficient mice. | 2012 Apr |
1 |
| 32 |
21126601 | Differential effects of gemfibrozil and fenofibrate on reverse cholesterol transport from macrophages to feces in vivo. | 2011 Feb |
1 |
| 33 |
21441141 | Peroxisome proliferator-activated receptor-α activation promotes macrophage reverse cholesterol transport through a liver X receptor-dependent pathway. | 2011 Jun |
6 |
| 34 |
22129452 | 13-hydroxy linoleic acid increases expression of the cholesterol transporters ABCA1, ABCG1 and SR-BI and stimulates apoA-I-dependent cholesterol efflux in RAW264.7 macrophages. | 2011 Nov 30 |
4 |
| 35 |
19960455 | Supplementation with the reduced form of Coenzyme Q10 decelerates phenotypic characteristics of senescence and induces a peroxisome proliferator-activated receptor-alpha gene expression signature in SAMP1 mice. | 2010 Jun |
1 |
| 36 |
21088444 | Aspirin increases apolipoprotein-A-I-mediated cholesterol efflux via enhancing expression of ATP-binding cassette transporter A1. | 2010 |
1 |
| 37 |
19067122 | Effects of high dietary fat and cholesterol on expression of PPAR alpha, LXR alpha, and their responsive genes in the liver of apoE and LDLR double deficient mice. | 2009 Mar |
1 |
| 38 |
19220285 | The dual PPARalpha/gamma agonist tesaglitazar blocks progression of pre-existing atherosclerosis in APOE*3Leiden.CETP transgenic mice. | 2009 Apr |
1 |
| 39 |
19930639 | Ciprofibrate increases cholesteryl ester transfer protein gene expression and the indirect reverse cholesterol transport to the liver. | 2009 Nov 23 |
3 |
| 40 |
18086530 | Cholesterol retention in Alzheimer's brain is responsible for high beta- and gamma-secretase activities and Abeta production. | 2008 Mar |
2 |
| 41 |
18489776 | PPARalpha-mediated effects of dietary lipids on intestinal barrier gene expression. | 2008 May 19 |
1 |
| 42 |
18498712 | The induction of atherogenic dyslipidaemia in poloxamer 407-treated mice is not mediated through PPARalpha. | 2008 Jun |
2 |
| 43 |
18758514 | Circulating free fatty acids are increased independently of PPARgamma activity after administration of poloxamer 407 to mice. | 2008 Sep |
1 |
| 44 |
18769950 | Conjugated linoleic acid isomers reduce cholesterol accumulation in acetylated LDL-induced mouse RAW264.7 macrophage-derived foam cells. | 2008 Oct |
2 |
| 45 |
18773970 | Coordinate induction of PPAR alpha and SREBP2 in multifunctional protein 2 deficient mice. | 2008 Nov-Dec |
1 |
| 46 |
17214990 | Increased atherosclerosis following treatment with a dual PPAR agonist in the ApoE knockout mouse. | 2007 Nov |
1 |
| 47 |
17495606 | Intestinal cholesterol transport proteins: an update and beyond. | 2007 Jun |
1 |
| 48 |
17724261 | Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice. | 2007 Sep 18 |
2 |
| 49 |
17726195 | Fenofibrate reduces intestinal cholesterol absorption via PPARalpha-dependent modulation of NPC1L1 expression in mouse. | 2007 Dec |
3 |
| 50 |
17014868 | Biochemical mechanism of insulin sensitization, lipid modulation and anti-atherogenic potential of PPAR alpha/gamma dual agonist: Ragaglitazar. | 2006 Dec 23 |
1 |