Title : 13-hydroxy linoleic acid increases expression of the cholesterol transporters ABCA1, ABCG1 and SR-BI and stimulates apoA-I-dependent cholesterol efflux in RAW264.7 macrophages.

Pub. Date : 2011 Nov 30

PMID : 22129452






4 Functional Relationships(s)
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1 BACKGROUND: Synthetic activators of peroxisome proliferator-activated receptors (PPARs) stimulate cholesterol removal from macrophages through PPAR-dependent up-regulation of liver x receptor alpha (LXRalpha) and subsequent induction of cholesterol exporters such as ATP-binding cassette transporter A1 (ABCA1) and scavenger receptor class B type 1 (SR-BI). Cholesterol peroxisome proliferator activated receptor alpha Mus musculus
2 BACKGROUND: Synthetic activators of peroxisome proliferator-activated receptors (PPARs) stimulate cholesterol removal from macrophages through PPAR-dependent up-regulation of liver x receptor alpha (LXRalpha) and subsequent induction of cholesterol exporters such as ATP-binding cassette transporter A1 (ABCA1) and scavenger receptor class B type 1 (SR-BI). Cholesterol peroxisome proliferator activated receptor alpha Mus musculus
3 Pre-treatment of cells with a selective PPARalpha or PPARgamma antagonist completely abolished the effects of 13-HODE on cholesterol efflux and protein levels of genes investigated. Cholesterol peroxisome proliferator activated receptor alpha Mus musculus
4 CONCLUSION: 13-HODE induces cholesterol efflux from macrophages via the PPAR-LXRalpha-ABCA1/SR-BI-pathway. Cholesterol peroxisome proliferator activated receptor alpha Mus musculus