Pub. Date : 2007 Dec
PMID : 17726195
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Fenofibrate reduces intestinal cholesterol absorption via PPARalpha-dependent modulation of NPC1L1 expression in mouse. | Cholesterol | peroxisome proliferator activated receptor alpha | Mus musculus |
| 2 | Treatment with PPARalpha agonists enhances fatty acid oxidation, decreases plasma triglycerides, and may promote reverse cholesterol transport. | Cholesterol | peroxisome proliferator activated receptor alpha | Mus musculus |
| 3 | These data demonstrate that fenofibrate specifically acts via PPARalpha to decrease cholesterol absorption at the level of intestinal NPC1L1 expression. | Cholesterol | peroxisome proliferator activated receptor alpha | Mus musculus |