Title : Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice.

Pub. Date : 2007 Sep 18

PMID : 17724261






2 Functional Relationships(s)
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1 Peritoneal macrophages from PPARalpha(-/-) mice had increased uptake of oxidized LDL and decreased cholesterol efflux. Cholesterol peroxisome proliferator activated receptor alpha Mus musculus
2 CONCLUSIONS: These data demonstrate that PPARalpha expression by macrophages has antiatherogenic effects via modulation of cell cholesterol trafficking and inflammatory activity. Cholesterol peroxisome proliferator activated receptor alpha Mus musculus