Title : Metformin may offer no protective effect in men undergoing external beam radiation therapy for prostate cancer.

Pub. Date : 2019 May

PMID : 31012989






2 Functional Relationships(s)
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1 To determine metformin"s effect on HIF1alpha expression and survival in vitro, PC3 cells with high basal HIF1alpha levels were subjected to increasing doses of metformin after H2 O2 -induced oxidative stress. Metformin hypoxia inducible factor 1 subunit alpha Homo sapiens
2 Higher, more toxic doses of metformin may be required to inhibit the mammalian target of rapamycin-HIF1alpha pathway in this patient group. Metformin hypoxia inducible factor 1 subunit alpha Homo sapiens