Pub. Date : 2014 Dec
PMID : 25310259
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin targeted the AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) pathway, suppressed the expression of hypoxia-inducible factor-1alpha (HIF-1alpha) and transcriptionally downregulated the expression of multidrug resistance protein 1/P-glycoprotein (P-gp) and multidrug resistance-associated protein 1 (MRP1). | Metformin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 2 | Metformin targeted the AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) pathway, suppressed the expression of hypoxia-inducible factor-1alpha (HIF-1alpha) and transcriptionally downregulated the expression of multidrug resistance protein 1/P-glycoprotein (P-gp) and multidrug resistance-associated protein 1 (MRP1). | Metformin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 3 | Collectively, these findings suggested that metformin may target the AMPK/mTOR/HIF-1alpha/P-gp and MRP1 pathways to reverse MDR in hepatocellular carcinoma. | Metformin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |