Pub. Date : 2015
PMID : 26101707
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin inhibits gastric cancer via the inhibition of HIF1alpha/PKM2 signaling. | Metformin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 2 | Metformin downregulated PI3K, Akt, HIF1alpha, PARP, PKM2 and COX expression. | Metformin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 3 | In summary, metformin has profound antitumor effect for gastric cancer by inducing intrinsic apoptosis via the inhibition of HIF1alpha/PKM2 signaling pathway. | Metformin | hypoxia inducible factor 1 subunit alpha | Homo sapiens |