Wortmannin

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ; Homo sapiens







23 Article(s)
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1 32152395 Angiotensin II represses Npr1 expression and receptor function by recruitment of transcription factors CREB and HSF-4a and activation of HDACs. 2020 Mar 9 1
2 26827608 Investigating the Inhibitory Effect of Wortmannin in the Hotspot Mutation at Codon 1047 of PIK3CA Kinase Domain: A Molecular Docking and Molecular Dynamics Approach. 2016 2
3 25636880 Pharmacogenomic and molecular docking studies on the cytotoxicity of the natural steroid wortmannin against multidrug-resistant tumor cells. 2015 Jan 15 1
4 25185846 CTRP3 improves the insulin sensitivity of 3T3-L1 adipocytes by inhibiting inflammation and ameliorating insulin signalling transduction. 2014 1
5 22613975 Mesangial medium from IgA nephropathy patients induces podocyte epithelial-to-mesenchymal transition through activation of the phosphatidyl inositol-3-kinase/Akt signaling pathway. 2012 1
6 23157418 Binding selectivity studies of phosphoinositide 3-kinases using free energy calculations. 2012 Dec 21 1
7 20036247 Role of growth factor receptor transactivation in high glucose-induced increased levels of Gq/11alpha and signaling in vascular smooth muscle cells. 2010 Aug 1
8 19805105 A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane. 2009 Oct 6 1
9 18653476 Activity of the p110-alpha subunit of phosphatidylinositol-3-kinase is required for activation of epithelial sodium transport. 2008 Sep 1
10 17456377 [Expression of phosphatidylinositol 3-kinase and effects of wortmannin on the expression of tumor necrosis factor-alpha in ulcerative colitis]. 2007 Feb 6 1
11 17007883 TNF-alpha induces Lnk expression through PI3K-dependent signaling pathway in human umbilical vein endothelial cells. 2006 Nov 1
12 16081599 HIV-1 gp120-induced TNF-{alpha} production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways. 2005 Oct 1
13 14711831 Protein kinase C-zeta and protein kinase B regulate distinct steps of insulin endocytosis and intracellular sorting. 2004 Mar 19 1
14 14982949 Fcgamma receptor signaling in primary human microglia: differential roles of PI-3K and Ras/ERK MAPK pathways in phagocytosis and chemokine induction. 2004 Jun 1
15 12540485 Hypoxia protects human lung microvascular endothelial and epithelial-like cells against oxygen toxicity: role of phosphatidylinositol 3-kinase. 2003 Feb 1
16 12419308 Modulation of CYP3A4 expression by ceramide in human colon carcinoma HT-29 cells. 2002 Nov 15 1
17 11278864 Role of phosphoinositide 3-kinase in monocyte recruitment under flow conditions. 2001 Jul 20 1
18 11792123 CD40 ligation induces macrophage IL-10 and TNF-alpha production: differential use of the PI3K and p42/44 MAPK-pathways. 2001 Nov 21 1
19 10208753 G-protein betagamma subunit-dependent phosphorylation of 62-kDa protein in the early signaling pathway of starfish oocyte maturation induced by 1-methyladenine. 1999 May 1 1
20 9603913 Inhibition by platelet-activating factor of Src- and hepatocyte growth factor-dependent invasiveness of intestinal and kidney epithelial cells. Phosphatidylinositol 3'-kinase is a critical mediator of tumor invasion. 1998 Jun 5 2
21 9434772 Expression, enzyme activity, and subcellular localization of mammalian target of rapamycin in insulin-responsive cells. 1997 Dec 29 1
22 8657148 Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction. 1996 Apr 5
23 7820549 The activation of phosphatidylinositol 3-kinase by Ras. 1994 Sep 1 1