Title : A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane.

Pub. Date : 2009 Oct 6

PMID : 19805105






1 Functional Relationships(s)
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1 We report the structure of the most common mutant of p110alpha in complex with two interacting domains of its regulatory partner (p85alpha), both free and bound to an inhibitor (wortmannin). Wortmannin phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Homo sapiens