Title : Inhibition by platelet-activating factor of Src- and hepatocyte growth factor-dependent invasiveness of intestinal and kidney epithelial cells. Phosphatidylinositol 3'-kinase is a critical mediator of tumor invasion.

Pub. Date : 1998 Jun 5

PMID : 9603913






2 Functional Relationships(s)
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1 The phosphatidylinositol 3"-kinase (PI3"-K) inhibitors wortmannin and LY294002 totally blocked the HGF-induced invasion. Wortmannin phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Homo sapiens
2 Similar effects were observed in ts-srcMDCK kidney epithelial cells transformed by a v-Src temperature-sensitive mutant: (i) PAF and wortmannin exerted additive inhibitory effects on Src-induced invasion and (ii) activated and dominant negative forms of p110alpha PI3"-K, respectively, amplified and abrogated the Src- and HGF-dependent invasiveness of parental and ts-srcMDCK cells. Wortmannin phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Homo sapiens