| 1 |
35355074 | Combination of monoammonium glycyrrhizinate and cysteine hydrochloride protects mice against acetaminophen-induced liver injury via Keap1/Nrf2/ARE pathway. | 2022 May 20 |
1 |
| 2 |
35588739 | Activation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDs. | 2022 Jun 14 |
2 |
| 3 |
33096251 | NRF2 activation by reversible KEAP1 binding induces the antioxidant response in primary neurons and astrocytes of a Huntington's disease mouse model. | 2021 Jan |
1 |
| 4 |
33335570 | Eugenol protects cells against oxidative stress via Nrf2. | 2021 Feb |
1 |
| 5 |
33357455 | Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis. | 2021 Jan 5 |
1 |
| 6 |
33391509 | Covalent modification of Keap1 at Cys77 and Cys434 by pubescenoside a suppresses oxidative stress-induced NLRP3 inflammasome activation in myocardial ischemia-reperfusion injury. | 2021 |
2 |
| 7 |
34737234 | Bach1 derepression is neuroprotective in a mouse model of Parkinson's disease. | 2021 Nov 9 |
1 |
| 8 |
31536771 | Seaweed natural products modify the host inflammatory response via Nrf2 signaling and alter colon microbiota composition and gene expression. | 2020 Jan |
1 |
| 9 |
31760092 | Trans-4,4'-dihydroxystilbene ameliorates cigarette smoke-induced progression of chronic obstructive pulmonary disease via inhibiting oxidative stress and inflammatory response. | 2020 May 20 |
2 |
| 10 |
31972171 | Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification. | 2020 Mar |
1 |
| 11 |
32020639 | The Nrf2 activator MIND4-17 protects retinal ganglion cells from high glucose-induced oxidative injury. | 2020 Oct |
2 |
| 12 |
32544505 | Combination of monoammonium glycyrrhizinate and cysteine hydrochloride ameliorated lipopolysaccharide/galactosamine-induced acute liver injury through Nrf2/ARE pathway. | 2020 Sep 5 |
1 |
| 13 |
32943614 | Four-octyl itaconate activates Nrf2 cascade to protect osteoblasts from hydrogen peroxide-induced oxidative injury. | 2020 Sep 17 |
1 |
| 14 |
32951003 | (+)-Clausenamide protects against drug-induced liver injury by inhibiting hepatocyte ferroptosis. | 2020 Sep 19 |
3 |
| 15 |
31315052 | Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap1. | 2019 Jul 16 |
2 |
| 16 |
31697998 | Amlexanox ameliorates acetaminophen-induced acute liver injury by reducing oxidative stress in mice. | 2019 Dec 15 |
1 |
| 17 |
29175486 | Targeting the 15-keto-PGE2-PTGR2 axis modulates systemic inflammation and survival in experimental sepsis. | 2018 Feb 1 |
1 |
| 18 |
29588164 | Nitrated fatty acids in cardiovascular diseases. | 2018 Mar 26 |
1 |
| 19 |
30342185 | S-Alk(en)ylmercaptocysteine suppresses LPS-induced pro-inflammatory responses in murine macrophages through inhibition of NF-κB pathway and modulation of thiol redox status. | 2018 Dec |
1 |
| 20 |
28735240 | Therapeutic effects of L-Cysteine in newborn mice subjected to hypoxia-ischemia brain injury via the CBS/H2S system: Role of oxidative stress and endoplasmic reticulum stress. | 2017 Oct |
1 |
| 21 |
26527616 | Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response. | 2016 Jan 15 |
1 |
| 22 |
25896849 | Ascorbic acid reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and improves survival rate in septic mice by activation of Nrf2/HO-1 signals. | 2015 Jun 15 |
1 |
| 23 |
26265043 | Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action. | 2015 Sep 25 |
1 |
| 24 |
26551704 | Interplay between cytosolic disulfide reductase systems and the Nrf2/Keap1 pathway. | 2015 Aug |
4 |
| 25 |
24489685 | Keap1 cysteine 288 as a potential target for diallyl trisulfide-induced Nrf2 activation. | 2014 |
3 |
| 26 |
25148906 | Ginger compound [6]-shogaol and its cysteine-conjugated metabolite (M2) activate Nrf2 in colon epithelial cells in vitro and in vivo. | 2014 Sep 15 |
3 |
| 27 |
22732183 | Validation of the multiple sensor mechanism of the Keap1-Nrf2 system. | 2012 Aug 15 |
2 |
| 28 |
22966037 | Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2. | 2012 Oct |
3 |
| 29 |
19808700 | Critical cysteine residues of Kelch-like ECH-associated protein 1 in arsenic sensing and suppression of nuclear factor erythroid 2-related factor 2. | 2010 Jan |
1 |
| 30 |
20122947 | The rise of antioxidant signaling--the evolution and hormetic actions of Nrf2. | 2010 Apr 1 |
2 |
| 31 |
20133743 | Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains. | 2010 Feb 16 |
1 |
| 32 |
20439747 | Electrophilic tuning of the chemoprotective natural product sulforaphane. | 2010 May 25 |
1 |
| 33 |
20463144 | Ajoene, a stable garlic by-product, has an antioxidant effect through Nrf2-mediated glutamate-cysteine ligase induction in HepG2 cells and primary hepatocytes. | 2010 Jul |
1 |
| 34 |
20478997 | Nrf2 establishes a glutathione-mediated gradient of UVB cytoprotection in the epidermis. | 2010 May 15 |
2 |
| 35 |
19560419 | Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response. | 2009 Jun 26 |
1 |
| 36 |
19778293 | Extracellular redox status regulates Nrf2 activation through mitochondrial reactive oxygen species. | 2009 Dec 10 |
3 |
| 37 |
18057000 | Molecular evolution of Keap1. Two Keap1 molecules with distinctive intervening region structures are conserved among fish. | 2008 Feb 8 |
3 |
| 38 |
18268004 | Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity. | 2008 Apr |
2 |
| 39 |
18785192 | The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system. | 2008 Oct |
6 |
| 40 |
14764894 | Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers. | 2004 Feb 17 |
3 |
| 41 |
15110385 | Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles. | 2004 May 15 |
1 |