Title : The Nrf2 activator MIND4-17 protects retinal ganglion cells from high glucose-induced oxidative injury.

Pub. Date : 2020 Oct

PMID : 32020639






2 Functional Relationships(s)
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1 High glucose (HG) induces oxidative injury and apoptosis in retinal ganglion cells (RGCs), serving as a primary pathological mechanism of DR. MIND4-17 activates nuclear-factor-E2-related factor 2 (Nrf2) signaling via modifying one cysteine (C151) residue of Kelch-like ECH-associated protein 1 (Keap1). Cysteine nuclear factor, erythroid derived 2, like 2 Mus musculus
2 High glucose (HG) induces oxidative injury and apoptosis in retinal ganglion cells (RGCs), serving as a primary pathological mechanism of DR. MIND4-17 activates nuclear-factor-E2-related factor 2 (Nrf2) signaling via modifying one cysteine (C151) residue of Kelch-like ECH-associated protein 1 (Keap1). Cysteine nuclear factor, erythroid derived 2, like 2 Mus musculus