Pub. Date : 2019 Jul 16
PMID : 31315052
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we show that a Keap1 mutant lacking 11 cysteine residues retains the ability to target Nrf2 for degradation, but it is unable to respond to cysteine-reactive Nrf2 inducers. | Cysteine | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 2 | This sensing mechanism is distinct from that used for electrophilic Nrf2 inducers, demonstrating that Keap1 is equipped with multiple cysteine-based sensors to detect various endogenous and exogenous stresses. | Cysteine | nuclear factor, erythroid derived 2, like 2 | Mus musculus |