Title : Ascorbic acid reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and improves survival rate in septic mice by activation of Nrf2/HO-1 signals.

Pub. Date : 2015 Jun 15

PMID : 25896849






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Mutation of cysteine to serine of keap-1 proteins (C151S, C273S, and C288S) lost the ability of HO-1 induction by AscA, due to failure of translocation of Nrf-2 to nucleus. Cysteine nuclear factor, erythroid derived 2, like 2 Mus musculus