| 251 |
20620997 | SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity. | 2010 Jul 7 |
2 |
| 252 |
20634564 | miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues. | 2010 Jul |
1 |
| 253 |
20655472 | SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10. | 2010 Jul 23 |
1 |
| 254 |
20668706 | SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kgamma Activity through Deacetylation of Specific Lysine Residues in Mammals. | 2010 Jul 23 |
1 |
| 255 |
21030595 | HDAC3 is negatively regulated by the nuclear protein DBC1. | 2010 Dec 24 |
1 |
| 256 |
21103071 | Liver steatosis and increased ChREBP expression in mice carrying a liver specific SIRT1 null mutation under a normal feeding condition. | 2010 Nov 16 |
1 |
| 257 |
18932012 | Converting NADH to NAD+ by nicotinamide nucleotide transhydrogenase as a novel strategy against mitochondrial pathologies during aging. | 2009 Aug |
2 |
| 258 |
19148549 | Chromosomal characterization and localization of the NAD+-dependent histone deacetylase gene sirtuin 1 in the mouse. | 2009 Feb |
1 |
| 259 |
19199480 | Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators. | 2009 Mar 12 |
1 |
| 260 |
19262508 | AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. | 2009 Apr 23 |
2 |
| 261 |
19284563 | Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo. | 2009 Mar 10 |
1 |
| 262 |
19286518 | Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1. | 2009 May 1 |
3 |
| 263 |
19288225 | Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons. | 2009 |
3 |
| 264 |
19306844 | Fluorescence in situ hybridization and chromosomal organization of the sirtuin 4 gene (Sirt4) in the mouse. | 2009 May 15 |
1 |
| 265 |
19470756 | SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1. | 2009 Aug |
1 |
| 266 |
19491102 | Sirtuin 1 functionally and physically interacts with disruptor of telomeric silencing-1 to regulate alpha-ENaC transcription in collecting duct. | 2009 Jul 31 |
2 |
| 267 |
19661458 | Nicotinamide phosphoribosyltransferase regulates cell survival through NAD+ synthesis in cardiac myocytes. | 2009 Aug 28 |
2 |
| 268 |
19672559 | Functional interplay between Parp-1 and SirT1 in genome integrity and chromatin-based processes. | 2009 Oct |
1 |
| 269 |
19680552 | CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage. | 2009 Aug 14 |
1 |
| 270 |
20228935 | Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SirT1 activity. | 2009 Dec 10 |
1 |
| 271 |
18005249 | Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice. | 2008 Jan |
1 |
| 272 |
18296641 | A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. | 2008 Mar 4 |
3 |
| 273 |
18662547 | The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. | 2008 Jul 25 |
2 |
| 274 |
18752667 | A high throughput live transparent animal bioassay to identify non-toxic small molecules or genes that regulate vertebrate fat metabolism for obesity drug development. | 2008 Aug 27 |
1 |
| 275 |
19046567 | Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. | 2008 Nov |
1 |
| 276 |
17197703 | Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1. | 2007 Mar 2 |
1 |
| 277 |
17482543 | Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+. | 2007 May 4 |
1 |
| 278 |
18046409 | Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. | 2007 Nov 29 |
1 |
| 279 |
16632544 | Poly(ADP-ribose) polymerase-1-deficient mice are protected from angiotensin II-induced cardiac hypertrophy. | 2006 Oct |
1 |
| 280 |
16917544 | The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity. | 2006 Sep |
5 |
| 281 |
16935261 | Regulation of SIRT 1 mediated NAD dependent deacetylation: a novel role for the multifunctional enzyme CD38. | 2006 Oct 13 |
3 |
| 282 |
16959573 | SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. | 2006 Sep 8 |
1 |
| 283 |
17174885 | In vino veritas: a tale of two sirt1s? | 2006 Dec 15 |
1 |
| 284 |
17380200 | Signaling properties of CD38 in the mouse immune system: enzyme-dependent and -independent roles in immunity. | 2006 Nov-Dec |
2 |
| 285 |
15795229 | Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase. | 2005 Jun 3 |
1 |
| 286 |
14706864 | Predominant expression of Sir2alpha, an NAD-dependent histone deacetylase, in the embryonic mouse heart and brain. | 2004 Jan 2 |
1 |
| 287 |
15381699 | The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells. | 2004 Dec 3 |
2 |
| 288 |
12899610 | Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry. | 2003 Aug 12 |
1 |
| 289 |
14523559 | Differential regulation of the Sir2 histone deacetylase gene family by inhibitors of class I and II histone deacetylases. | 2003 Sep |
1 |
| 290 |
11250901 | Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription. | 2001 Mar 15 |
1 |
| 291 |
10693811 | Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. | 2000 Feb 17 |
2 |