PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11250901-5 2001 Consistent with acetylation of TIF-IB/SL1 being required for rDNA transcription, the NAD(+)-dependent histone deacetylase mSir2a deacetylates TAF(I)68 and represses Pol I transcription. NAD 85-91 sirtuin 1 Mus musculus 122-128 10693811-5 2000 Here we show that yeast and mouse Sir2 proteins are nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylases, which deacetylate lysines 9 and 14 of H3 and specifically lysine 16 of H4. NAD 52-85 sirtuin 1 Mus musculus 34-38 10693811-5 2000 Here we show that yeast and mouse Sir2 proteins are nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylases, which deacetylate lysines 9 and 14 of H3 and specifically lysine 16 of H4. NAD 87-90 sirtuin 1 Mus musculus 34-38 25361036-5 2014 Interestingly, injection of PJ34, a PARP-1 inhibitor, in aged mice increased SIRT-1 activity by preserving intracellular NAD+ content, which resulted in higher skeletal muscle mitochondrial biogenesis and performance. NAD 121-125 sirtuin 1 Mus musculus 77-83 34928817-0 2021 NAD+ improved experimental autoimmune encephalomyelitis by regulating SIRT1 to inhibit PI3K/Akt/mTOR signaling pathway. NAD 0-4 sirtuin 1 Mus musculus 70-75 34928817-1 2021 OBJECTIVE: To investigate the effect of NAD+ on thymus autophagy in experimental autoimmune encephalomyelitis (EAE) mice through SIRT1. NAD 40-44 sirtuin 1 Mus musculus 129-134 34928817-10 2021 RESULTS: Enrichment analysis showed PI3K-Akt-mTOR and autophagy pathway were main terms in EAE diseases, and the relationship between NAD+ and SIRT1. NAD 134-138 sirtuin 1 Mus musculus 143-148 34928817-11 2021 The activation of p-PI3K, p-Akt and p-mTOR were the highest in the EAE group consistent with decreased P62, Beclin1, LC-3A/B and SIRT1, and NAD+ reversed these results, furthermore SIRT1 inhibitor: SIRT-IN3 weakened the NAD+" effects in both in vivo and in vitro experiments. NAD 140-144 sirtuin 1 Mus musculus 181-186 34928817-11 2021 The activation of p-PI3K, p-Akt and p-mTOR were the highest in the EAE group consistent with decreased P62, Beclin1, LC-3A/B and SIRT1, and NAD+ reversed these results, furthermore SIRT1 inhibitor: SIRT-IN3 weakened the NAD+" effects in both in vivo and in vitro experiments. NAD 220-224 sirtuin 1 Mus musculus 181-186 34928817-13 2021 CONCLUSIONS: NAD+ exerted a protective effect on EAE mice by inhibiting PI3K/Akt/mTOR signaling pathway through SIRT1 in TECs, and prevented EAE mice from sustained damage. NAD 13-17 sirtuin 1 Mus musculus 112-117 34959937-9 2021 Also, TGPN and PNY stimulated NAD-dependent deacetylase sirtuin-1(SIRT1), peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1alpha), nuclear respiratory factor 1,2, mitochondrial transcription factor A, along with mitochondrial DNA content via SIRT1/PGC-1alpha signaling. NAD 30-33 sirtuin 1 Mus musculus 66-71 34959937-9 2021 Also, TGPN and PNY stimulated NAD-dependent deacetylase sirtuin-1(SIRT1), peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1alpha), nuclear respiratory factor 1,2, mitochondrial transcription factor A, along with mitochondrial DNA content via SIRT1/PGC-1alpha signaling. NAD 30-33 sirtuin 1 Mus musculus 268-273 34531546-12 2021 The mechanisms underlying ROF neuroprotective effects appear to be associated with NAD+/SIRT1-dependent activation of lysosomal function. NAD 83-87 sirtuin 1 Mus musculus 88-93 34903884-0 2021 NADH inhibition of SIRT1 links energy state to transcription during time-restricted feeding. NAD 0-4 sirtuin 1 Mus musculus 19-24 34903884-1 2021 In mammals, circadian rhythms are entrained to the light cycle and drive daily oscillations in levels of NAD+, a cosubstrate of the class III histone deacetylase sirtuin 1 (SIRT1) that associates with clock transcription factors. NAD 105-109 sirtuin 1 Mus musculus 162-171 34903884-1 2021 In mammals, circadian rhythms are entrained to the light cycle and drive daily oscillations in levels of NAD+, a cosubstrate of the class III histone deacetylase sirtuin 1 (SIRT1) that associates with clock transcription factors. NAD 105-109 sirtuin 1 Mus musculus 173-178 34903884-6 2021 Enzymatic analyses reveal that NADH inhibits SIRT1 in vitro, corresponding with reduced deacetylation of SIRT1 substrates during TRF-CR in vivo. NAD 31-35 sirtuin 1 Mus musculus 45-50 34903884-6 2021 Enzymatic analyses reveal that NADH inhibits SIRT1 in vitro, corresponding with reduced deacetylation of SIRT1 substrates during TRF-CR in vivo. NAD 31-35 sirtuin 1 Mus musculus 105-110 34903884-8 2021 Our findings reveal that the hepatic NADH cycle links nutrient state to whole-body energetics through the rhythmic regulation of SIRT1. NAD 37-41 sirtuin 1 Mus musculus 129-134 34769515-5 2021 Dunnione increases the cellular NAD+ levels in lung tissues of tumor-bearing mice to restore the declining sirtuin 1 (SIRT1) activity, thus deacetylating nuclear factor-kappa B (NF-kappaB) and preventing the overexpression of tissue factor in bronchial epithelial and vascular endothelial cells. NAD 32-36 sirtuin 1 Mus musculus 107-116 34769515-5 2021 Dunnione increases the cellular NAD+ levels in lung tissues of tumor-bearing mice to restore the declining sirtuin 1 (SIRT1) activity, thus deacetylating nuclear factor-kappa B (NF-kappaB) and preventing the overexpression of tissue factor in bronchial epithelial and vascular endothelial cells. NAD 32-36 sirtuin 1 Mus musculus 118-123 34355499-2 2021 SIRT1 is a NAD+-dependent class III histone deacetylase, widely expresses in BLA. NAD 11-14 sirtuin 1 Mus musculus 0-5 34803499-10 2021 More importantly, Ex527 (Sirt1 inhibitor) and 3-TYP (Sirt3 inhibitor) significantly enhanced OA-induced lipid accumulation and oxidative stress in CD38-/- primary hepatocytes, suggesting that the anti-lipid accumulation of CD38 deficiency might be dependent on NAD/Sirtuins-mediated enhancement of FAA beta-oxidation and suppression of oxidative stress in hepatocytes. NAD 261-264 sirtuin 1 Mus musculus 25-30 34089817-0 2021 Modulation of NAD+ biosynthesis activates SIRT1 and resist cisplatin-induced ototoxicity. NAD 14-18 sirtuin 1 Mus musculus 42-47 34314389-6 2021 Lsd1 knockout reduces NAD+-dependent SIRT1 and SIRT7 deacetylase activity, leading to hyperacetylation and hypofunctioning of GABPbeta and PGC-1alpha, the major transcriptional factor/cofactor for nuclear-encoded mitochondrial genes. NAD 22-25 sirtuin 1 Mus musculus 37-42 34174704-10 2021 NAD+ intervention decreased pro-inflammatory cytokine mRNA and pro-apoptotic protein expression and enhanced anti-inflammatory cytokine mRNA expression and the SIRT1 signaling in the optic nerve and retina and regulated the Th1/Th17/Tregs immune response in the spleen. NAD 0-4 sirtuin 1 Mus musculus 160-165 34174704-11 2021 In addition, EX-527 reversed the therapeutic effect of NAD+ on EAE, suggesting that NAD+ prevented MS-triggered ON by activating the SIRT1 signaling pathway. NAD 55-59 sirtuin 1 Mus musculus 133-138 34174704-11 2021 In addition, EX-527 reversed the therapeutic effect of NAD+ on EAE, suggesting that NAD+ prevented MS-triggered ON by activating the SIRT1 signaling pathway. NAD 84-88 sirtuin 1 Mus musculus 133-138 34483906-4 2021 Sirtuin 1 (SIRT1), an NAD+-dependent deacetylase, plays a vital role in hepatic steatosis and inflammation. NAD 22-25 sirtuin 1 Mus musculus 0-9 34483906-4 2021 Sirtuin 1 (SIRT1), an NAD+-dependent deacetylase, plays a vital role in hepatic steatosis and inflammation. NAD 22-25 sirtuin 1 Mus musculus 11-16 34087956-5 2021 Mechanistic studies of replicative cellular senescence in the presence or absence of NLRX1 in vitro reveal that NLRX1-deficient fibroblasts fail to maintain optimal NAD+ /NADH ratio, which instigates the decline of SIRT1 and the activation of mTOR, p16INK4A , and p53, leading to the increase in senescence-associated beta-galactosidase (SA-beta-gal)-positive cells. NAD 165-169 sirtuin 1 Mus musculus 215-220 34087956-5 2021 Mechanistic studies of replicative cellular senescence in the presence or absence of NLRX1 in vitro reveal that NLRX1-deficient fibroblasts fail to maintain optimal NAD+ /NADH ratio, which instigates the decline of SIRT1 and the activation of mTOR, p16INK4A , and p53, leading to the increase in senescence-associated beta-galactosidase (SA-beta-gal)-positive cells. NAD 171-175 sirtuin 1 Mus musculus 215-220 34484659-1 2021 Sirtuin 1 (SIRT1), the NAD-dependent histone deacetylase, has been extensively investigated due to its cognitive protective effect. NAD 23-26 sirtuin 1 Mus musculus 0-9 34484659-1 2021 Sirtuin 1 (SIRT1), the NAD-dependent histone deacetylase, has been extensively investigated due to its cognitive protective effect. NAD 23-26 sirtuin 1 Mus musculus 11-16 33271594-1 2021 Caloric restriction (CR) has been shown repeatedly to prolong the lifespan in laboratory animals, with its benefits dependent on molecular targets forming part of the nutrient signaling network, including the NAD-dependent deacetylase silent mating type information regulation 2 homologue 1 (SIRT1). NAD 209-212 sirtuin 1 Mus musculus 292-297 34766147-4 2021 Supplementing NAD+ intermediates can activate sirtuin deacylases (SIRT1-SIRT7), which regulates the benefits of exercise and dietary restriction, reduce the level of intracellular oxidative stress, and improve mitochondrial function, thereby reversing cell senescence. NAD 14-18 sirtuin 1 Mus musculus 66-71 35381294-7 2022 Mechanistically, the inhibiting effect was attributed to the direct and indirect regulatory effect of DDIT3 on SIRT1 (sirtuin1, silent mating type information regulation protein type 1, a member of NAD+ dependent class III histone deacetylases). NAD 198-201 sirtuin 1 Mus musculus 111-116 35381294-7 2022 Mechanistically, the inhibiting effect was attributed to the direct and indirect regulatory effect of DDIT3 on SIRT1 (sirtuin1, silent mating type information regulation protein type 1, a member of NAD+ dependent class III histone deacetylases). NAD 198-201 sirtuin 1 Mus musculus 118-126 35504092-7 2022 Subsequently, the increased NAD+ upregulated the expression of Sirt1, SOD2 and attenuated DNA damage. NAD 28-32 sirtuin 1 Mus musculus 63-68 35490894-11 2022 CONCLUSION: In view of the findings, crocin ameliorates depression in mice, which may be associated with regulating NAMPT-NAD+-SIRT1 pathway. NAD 122-126 sirtuin 1 Mus musculus 127-132 35538652-8 2022 Furthermore, NAD+-mediated mitonuclear protein imbalance and UPRmt are probably regulated by deacetylase Sirtuin1 (SIRT1). NAD 13-17 sirtuin 1 Mus musculus 105-113 35538652-8 2022 Furthermore, NAD+-mediated mitonuclear protein imbalance and UPRmt are probably regulated by deacetylase Sirtuin1 (SIRT1). NAD 13-17 sirtuin 1 Mus musculus 115-120 35561022-3 2022 Sirtuin-1 (Sirt1), a NAD-dependent deacetylase, regulates cellular metabolic activity and activation of this protein has been associated with vasoprotection in aged mice. NAD 21-24 sirtuin 1 Mus musculus 0-9 35561022-3 2022 Sirtuin-1 (Sirt1), a NAD-dependent deacetylase, regulates cellular metabolic activity and activation of this protein has been associated with vasoprotection in aged mice. NAD 21-24 sirtuin 1 Mus musculus 11-16 35452563-1 2022 Emerging evidence suggests an important role for SIRT1, a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase in cancer development, progression and therapeutic resistance; making it a viable therapeutic target. NAD 58-91 sirtuin 1 Mus musculus 49-54 35452563-1 2022 Emerging evidence suggests an important role for SIRT1, a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase in cancer development, progression and therapeutic resistance; making it a viable therapeutic target. NAD 93-96 sirtuin 1 Mus musculus 49-54 35139656-2 2022 Nicotinamide adenine dinucleotide (NAD+) acts as a signaling molecule, and its levels were used to govern several biological pathways, for example, promoting angiogenesis by SIRT1 (sirtuin 1)-mediated inhibition of Notch signaling to rejuvenate capillary density of old-aged mice. NAD 0-33 sirtuin 1 Mus musculus 174-179 35139656-2 2022 Nicotinamide adenine dinucleotide (NAD+) acts as a signaling molecule, and its levels were used to govern several biological pathways, for example, promoting angiogenesis by SIRT1 (sirtuin 1)-mediated inhibition of Notch signaling to rejuvenate capillary density of old-aged mice. NAD 0-33 sirtuin 1 Mus musculus 181-190 35139656-2 2022 Nicotinamide adenine dinucleotide (NAD+) acts as a signaling molecule, and its levels were used to govern several biological pathways, for example, promoting angiogenesis by SIRT1 (sirtuin 1)-mediated inhibition of Notch signaling to rejuvenate capillary density of old-aged mice. NAD 35-39 sirtuin 1 Mus musculus 174-179 35139656-2 2022 Nicotinamide adenine dinucleotide (NAD+) acts as a signaling molecule, and its levels were used to govern several biological pathways, for example, promoting angiogenesis by SIRT1 (sirtuin 1)-mediated inhibition of Notch signaling to rejuvenate capillary density of old-aged mice. NAD 35-39 sirtuin 1 Mus musculus 181-190 35318613-5 2022 In this report, we identify a crucial role for the NAD+-dependent histone deacetylase Sirtuin 1 (Sirt1) downstream of PKA and CREB in dmPGE2-dependent radioprotection of hematopoietic cells. NAD 51-55 sirtuin 1 Mus musculus 86-95 35318613-5 2022 In this report, we identify a crucial role for the NAD+-dependent histone deacetylase Sirtuin 1 (Sirt1) downstream of PKA and CREB in dmPGE2-dependent radioprotection of hematopoietic cells. NAD 51-55 sirtuin 1 Mus musculus 97-102 35419389-4 2022 Here, we identify PPARalpha as a deacetylation target of the NAD-dependent deacetylase sirtuin-1 (SIRT1) and link this to the decrease in PPARalpha protein levels in undernourished liver. NAD 61-64 sirtuin 1 Mus musculus 98-103 35408818-6 2022 Accordingly, FK866, a NAMPT inhibitor, and quercetin, a Sirt1 agonist, have favorable effects on the maintenance of NAD+ homeostasis and renal function in db/db mice. NAD 116-120 sirtuin 1 Mus musculus 56-61 35235362-5 2022 By using a series of adipose tissue and brain region-specific loss- and gain-of-function approaches, we implicate impaired nicotinamide adenine dinucleotide (NAD+)/SIRT1 pathway in the nucleus accumbens. NAD 123-156 sirtuin 1 Mus musculus 164-169 35001440-2 2022 At the molecular level, the circadian molecular clock and cellular metabolic state may be interconnected through interactions with the nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, Sirtuin 1 (SIRT1). NAD 135-168 sirtuin 1 Mus musculus 199-208 35001440-2 2022 At the molecular level, the circadian molecular clock and cellular metabolic state may be interconnected through interactions with the nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, Sirtuin 1 (SIRT1). NAD 135-168 sirtuin 1 Mus musculus 210-215 35001440-2 2022 At the molecular level, the circadian molecular clock and cellular metabolic state may be interconnected through interactions with the nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, Sirtuin 1 (SIRT1). NAD 170-174 sirtuin 1 Mus musculus 199-208 35001440-2 2022 At the molecular level, the circadian molecular clock and cellular metabolic state may be interconnected through interactions with the nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, Sirtuin 1 (SIRT1). NAD 170-174 sirtuin 1 Mus musculus 210-215 35001440-3 2022 In the nucleus accumbens (NAc), a region important for reward, both SIRT1 and the circadian transcription factor neuronal PAS domain protein 2 (NPAS2) are highly enriched, and both are regulated by the metabolic cofactor NAD+. NAD 221-225 sirtuin 1 Mus musculus 68-73 35090502-13 2022 CONCLUSIONS: All these data suggest that NQO1 has a protective effect against oxidative stress and apoptosis in DN, which may be mediated by the regulation of Sirt1 through increasing intracellular NAD+/NADH levels. NAD 198-202 sirtuin 1 Mus musculus 159-164 35090502-13 2022 CONCLUSIONS: All these data suggest that NQO1 has a protective effect against oxidative stress and apoptosis in DN, which may be mediated by the regulation of Sirt1 through increasing intracellular NAD+/NADH levels. NAD 203-207 sirtuin 1 Mus musculus 159-164 33689947-5 2021 Our results showed that exposure to PFOS inhibited silent information regulator 1 (SIRT1) activity, and molecular simulation showed PFOS could fit into the pocket overlapped with the nicotinamide adenine dinucleotide (NAD+) binding cavity in SIRT1. NAD 183-216 sirtuin 1 Mus musculus 51-81 33689947-5 2021 Our results showed that exposure to PFOS inhibited silent information regulator 1 (SIRT1) activity, and molecular simulation showed PFOS could fit into the pocket overlapped with the nicotinamide adenine dinucleotide (NAD+) binding cavity in SIRT1. NAD 183-216 sirtuin 1 Mus musculus 83-88 33689947-5 2021 Our results showed that exposure to PFOS inhibited silent information regulator 1 (SIRT1) activity, and molecular simulation showed PFOS could fit into the pocket overlapped with the nicotinamide adenine dinucleotide (NAD+) binding cavity in SIRT1. NAD 183-216 sirtuin 1 Mus musculus 242-247 33689947-5 2021 Our results showed that exposure to PFOS inhibited silent information regulator 1 (SIRT1) activity, and molecular simulation showed PFOS could fit into the pocket overlapped with the nicotinamide adenine dinucleotide (NAD+) binding cavity in SIRT1. NAD 218-222 sirtuin 1 Mus musculus 51-81 33689947-5 2021 Our results showed that exposure to PFOS inhibited silent information regulator 1 (SIRT1) activity, and molecular simulation showed PFOS could fit into the pocket overlapped with the nicotinamide adenine dinucleotide (NAD+) binding cavity in SIRT1. NAD 218-222 sirtuin 1 Mus musculus 83-88 33689947-5 2021 Our results showed that exposure to PFOS inhibited silent information regulator 1 (SIRT1) activity, and molecular simulation showed PFOS could fit into the pocket overlapped with the nicotinamide adenine dinucleotide (NAD+) binding cavity in SIRT1. NAD 218-222 sirtuin 1 Mus musculus 242-247 33795425-1 2021 BACKGROUND: The activation of NAD+-dependent deacetylase, Sirt1, by the administration of nicotinamide mononucleotide (NMN) ameliorates various aging-related diseases. NAD 30-33 sirtuin 1 Mus musculus 58-63 34009633-8 2021 CONCLUSION: These results indicate that long-term UVA eye irradiation stimulates p53, inhibits the clock gene, and reduces Sirt1 production in the NAD+ constructional system, resulting in reduced memory and learning ability. NAD 147-151 sirtuin 1 Mus musculus 123-128 33924243-2 2021 SIRT1, an NAD-dependent deacetylase, was shown to be one of the critical regulators of eNOS. NAD 10-13 sirtuin 1 Mus musculus 0-5 33846538-0 2021 Nicotinamide riboside, an NAD+ precursor, attenuates inflammation and oxidative stress by activating sirtuin 1 in alcohol-stimulated macrophages. NAD 26-30 sirtuin 1 Mus musculus 101-110 33846538-12 2021 In conclusion, NR exerts anti-inflammatory and antioxidant properties by abrogating the inhibitory effects of ethanol on the SIRT1 pathway by increasing Sirt1 expression and its activator, NAD+. NAD 189-193 sirtuin 1 Mus musculus 125-130 33846538-13 2021 Also, SIRT1 activation and normalization of ethanol-induced changes in NAD+/NADH ratios by NR are likely crucial to counteract the changes in energy phenotypes of macrophages exposed to ethanol. NAD 76-80 sirtuin 1 Mus musculus 6-11 33609723-8 2021 The NAD+ precursor nicotinamide mononucleotide and the poly ADP-ribose polymerase (PARP1) inhibitor olaparib also exerted anti-senescent effects by activating SIRT1. NAD 4-8 sirtuin 1 Mus musculus 159-164 33795658-4 2021 The NAD+-dependent Sirtuin1 (Sirt1) deacetylates FoxOs and beta-catenin in osteoblast progenitors and, thereby, increases bone mass. NAD 4-8 sirtuin 1 Mus musculus 19-27 33795658-4 2021 The NAD+-dependent Sirtuin1 (Sirt1) deacetylates FoxOs and beta-catenin in osteoblast progenitors and, thereby, increases bone mass. NAD 4-8 sirtuin 1 Mus musculus 29-34 33758176-1 2021 Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase belonging to class III histone deacetylases. NAD 23-56 sirtuin 1 Mus musculus 0-9 33758176-1 2021 Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase belonging to class III histone deacetylases. NAD 23-56 sirtuin 1 Mus musculus 11-16 33758176-1 2021 Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase belonging to class III histone deacetylases. NAD 58-62 sirtuin 1 Mus musculus 0-9 33758176-1 2021 Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase belonging to class III histone deacetylases. NAD 58-62 sirtuin 1 Mus musculus 11-16 33796837-4 2021 To address these questions, we develop a comprehensive mathematical model that represents the circadian pathway in the mouse liver, together with the insulin/IGF-1 pathway, mTORC1, AMPK, NAD+, and the NAD+ -consuming factor SIRT1. NAD 201-205 sirtuin 1 Mus musculus 224-229 33335015-1 2021 Resveratrol affords protection against reactive oxygen species (ROS)-related diseases via activation of SIRT1, an NAD+-dependent deacetylase. NAD 114-117 sirtuin 1 Mus musculus 104-109 33462707-8 2021 Although a number of different mechanisms may be at play in each case, a common theme is that resveratrol and NAD both enhance the activity of SIRT1. NAD 110-113 sirtuin 1 Mus musculus 143-148 33462707-9 2021 Moreover, many of the physiologic improvements observed with resveratrol and NAD precursors are consistent with modulation of known SIRT1 targets. NAD 77-80 sirtuin 1 Mus musculus 132-137 32712045-0 2021 Sleeve gastrectomy ameliorated high-fat diet (HFD)-induced non-alcoholic fatty liver disease and upregulated the nicotinamide adenine dinucleotide +/ Sirtuin-1 pathway in mice. NAD 113-146 sirtuin 1 Mus musculus 150-159 33053398-2 2021 In diabetic cornea, the NAD+-consuming enzyme SIRT1 was down-regulated and contributed to the delayed wound healing. NAD 24-28 sirtuin 1 Mus musculus 46-51 33053398-12 2021 Furthermore, in DM mice, NAD+ and its precursors nicotinamide mononucleotide and nicotinamide riboside also facilitated corneal epithelial and nerve regeneration, accompanied with the recovered expression of SIRT1 and phosphorylated EGFR, AKT, and ERK1/2 in epithelium and corneal sensitivity. NAD 25-29 sirtuin 1 Mus musculus 208-213 31710686-8 2020 Mechanistically, both niacin and nicotinamide supplementation increased nicotinamide adenine dinucleotide (NAD+) levels and NAD+-dependent Sirt1 activity, which were reduced in AAA tissues. NAD 124-127 sirtuin 1 Mus musculus 139-144 33010255-5 2020 The present study was undertaken to elucidate whether the NAD-dependent protein deacetylase sirtuin isoform SIRT1 is an upstream mediator of hypoxic PC-induced protection, and to assess the efficacy of the SIRT1-activating polyphenol Resveratrol as a pharmacologic preconditioning therapy. NAD 58-61 sirtuin 1 Mus musculus 108-113 33228716-1 2020 Sirtuin 1 (SIRT1), is a nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylase and a candidate gene for depression. NAD 24-57 sirtuin 1 Mus musculus 0-9 33228716-1 2020 Sirtuin 1 (SIRT1), is a nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylase and a candidate gene for depression. NAD 24-57 sirtuin 1 Mus musculus 11-16 33228716-1 2020 Sirtuin 1 (SIRT1), is a nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylase and a candidate gene for depression. NAD 59-63 sirtuin 1 Mus musculus 0-9 33228716-1 2020 Sirtuin 1 (SIRT1), is a nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylase and a candidate gene for depression. NAD 59-63 sirtuin 1 Mus musculus 11-16 32758058-8 2020 Low-dose (10 nM) NAD+ precursors (nicotinic acid, nicotinamide mononucleotide, and nicotinamide riboside) synergized with leucine to increase Sirt1 activity in adipocytes, hepatocytes, and muscle cells (30-100%, P < .01) and lifespan in Caenorhabditis elegans (25%, P = .025) and to significantly regress atherosclerotic lesion size and macrophage infiltration in a mouse model of atherosclerosis. NAD 17-21 sirtuin 1 Mus musculus 142-147 32502419-2 2020 (2020) now show that nicotinamide adenine dinucleotide (NAD+) can restore robust circadian gene expression and behavior in aged mice through SIRT1-dependent deacetylation of the core clock protein PER2. NAD 21-54 sirtuin 1 Mus musculus 141-146 32502419-2 2020 (2020) now show that nicotinamide adenine dinucleotide (NAD+) can restore robust circadian gene expression and behavior in aged mice through SIRT1-dependent deacetylation of the core clock protein PER2. NAD 56-60 sirtuin 1 Mus musculus 141-146 32278117-3 2020 This study aims to identify changes of specific components of NAD+/SIRTs system in white adipose tissue (WAT) and brown adipose tissue (BAT) of mice upon energy imbalance, focusing on key enzymes in NAD+ salvage (Nampt, Nmnat1, Nrk1), clearance (Nnmt, Aox1, Cyp2e1) and consumption pathways (Sirt1, Sirt2, Sirt3, Sirt6, Parp1). NAD 62-66 sirtuin 1 Mus musculus 292-297 32278117-3 2020 This study aims to identify changes of specific components of NAD+/SIRTs system in white adipose tissue (WAT) and brown adipose tissue (BAT) of mice upon energy imbalance, focusing on key enzymes in NAD+ salvage (Nampt, Nmnat1, Nrk1), clearance (Nnmt, Aox1, Cyp2e1) and consumption pathways (Sirt1, Sirt2, Sirt3, Sirt6, Parp1). NAD 199-203 sirtuin 1 Mus musculus 292-297 32278117-8 2020 The change trend of SIRT1 is quite the same as that of NAD+/NADH ratio. NAD 55-59 sirtuin 1 Mus musculus 20-25 32278117-8 2020 The change trend of SIRT1 is quite the same as that of NAD+/NADH ratio. NAD 60-64 sirtuin 1 Mus musculus 20-25 32301489-9 2020 Western blot showed that NAD+ treatment up-regulated the expression of p-STAT6 and SIRT1. NAD 25-29 sirtuin 1 Mus musculus 83-88 32426286-0 2020 Sirtuin 1 Inhibiting Thiocyanates (S1th)-A New Class of Isotype Selective Inhibitors of NAD+ Dependent Lysine Deacetylases. NAD 88-91 sirtuin 1 Mus musculus 0-9 32426286-1 2020 Sirtuin 1 (Sirt1) is a NAD+ dependent lysine deacetylase associated with the pathogenesis of various diseases including cancer. NAD 23-26 sirtuin 1 Mus musculus 0-9 32426286-1 2020 Sirtuin 1 (Sirt1) is a NAD+ dependent lysine deacetylase associated with the pathogenesis of various diseases including cancer. NAD 23-26 sirtuin 1 Mus musculus 11-16 32056076-8 2020 The transcriptional footprint of NMN treatment indicates that increased NAD+ levels promote SIRT1 activation in the neurovascular unit, as demonstrated by analysis of upstream regulators of differentially expressed genes as well as analysis of the expression of known SIRT1-dependent genes. NAD 72-75 sirtuin 1 Mus musculus 92-97 32280711-1 2020 Objective: To explore the effects of N1-methylnicotinamide (MNAM) on insulin resistance and glucose metabolism in obese type 2 diabetes mellitus (T2DM) mice and regulatory mechanisms of the NAD-dependent deacetylase sirtuin-1 (SIRT1)/forkhead box protein O1 (FOXO1) pathway. NAD 190-193 sirtuin 1 Mus musculus 227-232 31987812-7 2020 The mitochondrial uncoupling effects of embelin leading to increased NAD/NADH levels followed by enhanced SIRT1, PGC1alpha and mitochondrial biogenesis were found to confer embelin mediated protection as treatment of cells with SIRT1 inhibitor or siRNA nullified this effect. NAD 73-77 sirtuin 1 Mus musculus 228-233 32003501-6 2020 Our data show that the NAD+ -dependent deacetylase silent information regulator 1 (Sirt1) mediates Res-induced browning and fat reduction of adipocytes, as well as other Res-improved metabolic phenotypes including hyperglycemina and hyperlipidemia in mice. NAD 23-26 sirtuin 1 Mus musculus 51-81 32003501-6 2020 Our data show that the NAD+ -dependent deacetylase silent information regulator 1 (Sirt1) mediates Res-induced browning and fat reduction of adipocytes, as well as other Res-improved metabolic phenotypes including hyperglycemina and hyperlipidemia in mice. NAD 23-26 sirtuin 1 Mus musculus 83-88 32081881-9 2020 In parallel, laminar flow led to the increased expression of SIRT1 protein, a NAD+-dependent deacetylase. NAD 78-81 sirtuin 1 Mus musculus 61-66 31859031-1 2020 Sirtuin 1 (Sirt1) is a NAD+-dependent deacetylase capable of countering age-related neurodegeneration, but the basis of Sirt1 neuroprotection remains elusive. NAD 23-26 sirtuin 1 Mus musculus 0-9 31859031-1 2020 Sirtuin 1 (Sirt1) is a NAD+-dependent deacetylase capable of countering age-related neurodegeneration, but the basis of Sirt1 neuroprotection remains elusive. NAD 23-26 sirtuin 1 Mus musculus 11-16 31859031-4 2020 Transcription-factor binding-site analysis of downregulated genes yielded Sirt1 target sites, and we observed reduced Sirt1 activity in the SCA7 mouse cerebellum with NAD+ depletion. NAD 167-171 sirtuin 1 Mus musculus 118-123 32059481-16 2020 Consistently, the inhibition of both PARP-1 and SIRT-1 increased the NAD+/NADH-ratio in BAFs. NAD 69-72 sirtuin 1 Mus musculus 48-54 32059481-16 2020 Consistently, the inhibition of both PARP-1 and SIRT-1 increased the NAD+/NADH-ratio in BAFs. NAD 74-78 sirtuin 1 Mus musculus 48-54 32059481-17 2020 This suggests that cellular NAD+/NADH ratios control the complex interactions of PARP-1, H1 and SIRT-1 and regulate the interplay of parylation and acetylation/de-acetylation events with low NAD+/NADH ratios (reverse Warburg effect), promoting PARP-1 activation and estrogen synthesis in BAFs. NAD 28-31 sirtuin 1 Mus musculus 96-102 32059481-17 2020 This suggests that cellular NAD+/NADH ratios control the complex interactions of PARP-1, H1 and SIRT-1 and regulate the interplay of parylation and acetylation/de-acetylation events with low NAD+/NADH ratios (reverse Warburg effect), promoting PARP-1 activation and estrogen synthesis in BAFs. NAD 33-37 sirtuin 1 Mus musculus 96-102 32059481-17 2020 This suggests that cellular NAD+/NADH ratios control the complex interactions of PARP-1, H1 and SIRT-1 and regulate the interplay of parylation and acetylation/de-acetylation events with low NAD+/NADH ratios (reverse Warburg effect), promoting PARP-1 activation and estrogen synthesis in BAFs. NAD 33-36 sirtuin 1 Mus musculus 96-102 32059481-17 2020 This suggests that cellular NAD+/NADH ratios control the complex interactions of PARP-1, H1 and SIRT-1 and regulate the interplay of parylation and acetylation/de-acetylation events with low NAD+/NADH ratios (reverse Warburg effect), promoting PARP-1 activation and estrogen synthesis in BAFs. NAD 196-200 sirtuin 1 Mus musculus 96-102 32110174-10 2020 Moreover, PSPC activated Sirt1 by boosting NAD+ level in HFD-treated mouse livers. NAD 43-47 sirtuin 1 Mus musculus 25-30 32017914-15 2020 However, EX-527(inhibitor of SIRT1) decreased NAD+/NADH ratio and increased acetyl-p53 levels, and abolished the cardioprotective effects of taurine on mice subjected to TAC and increased apoptosis and oxidative stress. NAD 46-50 sirtuin 1 Mus musculus 29-34 32017914-15 2020 However, EX-527(inhibitor of SIRT1) decreased NAD+/NADH ratio and increased acetyl-p53 levels, and abolished the cardioprotective effects of taurine on mice subjected to TAC and increased apoptosis and oxidative stress. NAD 51-55 sirtuin 1 Mus musculus 29-34 31241768-8 2020 These data show that SCD1 is involved in nucleotide (ATP and NAD+ ) metabolism and suggest that the SCD1-dependent regulation of muscle steatosis and insulin sensitivity are mediated by cooperation between AMPK- and SIRT1-regulated pathways. NAD 61-65 sirtuin 1 Mus musculus 216-221 31618623-2 2020 Recent accumulating evidences suggest that Sirtuin 1 (SIRT1), an NAD+-dependent deacetylase, plays a key role in mood regulation, yet its role in the polarization of microglia acting on depressive behaviors remains unknown. NAD 65-68 sirtuin 1 Mus musculus 43-52 31618623-2 2020 Recent accumulating evidences suggest that Sirtuin 1 (SIRT1), an NAD+-dependent deacetylase, plays a key role in mood regulation, yet its role in the polarization of microglia acting on depressive behaviors remains unknown. NAD 65-68 sirtuin 1 Mus musculus 54-59 31754701-2 2019 The nicotinamide-adenine dinucleotide (NAD+)-dependent deacetylase enzyme, Sirtuin 1 (SIRT1), can prevent activation of these pathways and promote axonal regeneration. NAD 4-37 sirtuin 1 Mus musculus 75-84 31754701-2 2019 The nicotinamide-adenine dinucleotide (NAD+)-dependent deacetylase enzyme, Sirtuin 1 (SIRT1), can prevent activation of these pathways and promote axonal regeneration. NAD 4-37 sirtuin 1 Mus musculus 86-91 31754701-2 2019 The nicotinamide-adenine dinucleotide (NAD+)-dependent deacetylase enzyme, Sirtuin 1 (SIRT1), can prevent activation of these pathways and promote axonal regeneration. NAD 39-43 sirtuin 1 Mus musculus 75-84 31754701-2 2019 The nicotinamide-adenine dinucleotide (NAD+)-dependent deacetylase enzyme, Sirtuin 1 (SIRT1), can prevent activation of these pathways and promote axonal regeneration. NAD 39-43 sirtuin 1 Mus musculus 86-91 31693862-5 2019 Here, sirtuin 1 (SIRT1), an NAD-dependent deacetylase, was demonstrated to activate mouse PFs independent of its deacetylase activity. NAD 28-31 sirtuin 1 Mus musculus 6-15 31693862-5 2019 Here, sirtuin 1 (SIRT1), an NAD-dependent deacetylase, was demonstrated to activate mouse PFs independent of its deacetylase activity. NAD 28-31 sirtuin 1 Mus musculus 17-22 31702813-7 2019 Administration of NAD+ may also increase the expression of the key protein NAMPT and its related protein sirtuin 1 as well as the synthesis of NAD+. NAD 18-22 sirtuin 1 Mus musculus 105-114 31636473-1 2019 BACKGROUND: Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylase that is involved in various diseases, including cancers, metabolic diseases, and inflammation-associated diseases. NAD 35-68 sirtuin 1 Mus musculus 12-21 31636473-1 2019 BACKGROUND: Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylase that is involved in various diseases, including cancers, metabolic diseases, and inflammation-associated diseases. NAD 35-68 sirtuin 1 Mus musculus 23-28 31636473-1 2019 BACKGROUND: Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylase that is involved in various diseases, including cancers, metabolic diseases, and inflammation-associated diseases. NAD 70-74 sirtuin 1 Mus musculus 12-21 31636473-1 2019 BACKGROUND: Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylase that is involved in various diseases, including cancers, metabolic diseases, and inflammation-associated diseases. NAD 70-74 sirtuin 1 Mus musculus 23-28 31347918-3 2019 NAD is directly involved in various metabolic processes and may indirectly regulate metabolic gene expression through Sirt1, an NAD-dependent protein deacetylase. NAD 0-3 sirtuin 1 Mus musculus 118-123 31347918-3 2019 NAD is directly involved in various metabolic processes and may indirectly regulate metabolic gene expression through Sirt1, an NAD-dependent protein deacetylase. NAD 128-131 sirtuin 1 Mus musculus 118-123 31347918-8 2019 On the other hand, the NAD level was increased in Tg-Nampt mice at baseline but not during PO, possibly due to increased consumption of NAD by Sirt1. NAD 23-26 sirtuin 1 Mus musculus 143-148 31347918-8 2019 On the other hand, the NAD level was increased in Tg-Nampt mice at baseline but not during PO, possibly due to increased consumption of NAD by Sirt1. NAD 136-139 sirtuin 1 Mus musculus 143-148 31576091-13 2019 Parp1 and Sirt1 are two NAD+-dependent enzymes which play major roles in the decision of a cell to live or die in the context of stress . NAD 24-27 sirtuin 1 Mus musculus 10-15 31576091-14 2019 We showed that NAD+ depletion attributed to Parp1 activation after DNA damage was caused by oxidative stress in hepatocytes and resulted in Sirt1 activity inhibition. NAD 15-18 sirtuin 1 Mus musculus 140-145 31763496-1 2019 BACKGROUND: Sirtuin 1 (SIRT1) is a NAD+-dependent enzyme that has important roles in many biological processes involved in aging, including cell growth and repair, inflammation, and energy regulation. NAD 35-38 sirtuin 1 Mus musculus 12-21 31763496-1 2019 BACKGROUND: Sirtuin 1 (SIRT1) is a NAD+-dependent enzyme that has important roles in many biological processes involved in aging, including cell growth and repair, inflammation, and energy regulation. NAD 35-38 sirtuin 1 Mus musculus 23-28 31415077-9 2019 The replenishment of NMN or NAD+ partially slowed down corneal nerve fiber degeneration, reduced the epithelial defect in denervated mice, and improved apoptosis induction in FK866-treated cells by restoring the activation levels of SIRT1, AKT, and CREB. NAD 28-32 sirtuin 1 Mus musculus 233-238 31102152-1 2019 Sirt1, also known as the longevity gene, is an NAD+-dependent class III histone deacetylase that has been extensively studied in multiple areas of research including cellular metabolism, longevity, cancer, autoimmunity, and immunity. NAD 47-51 sirtuin 1 Mus musculus 0-5 31242212-1 2019 Activation of SIRT1, an NAD+-dependent protein deacetylase, ameliorates muscular pathophysiology of delta-sarcoglycan-deficient TO-2 hamsters and dystrophin-deficient mdx mice. NAD 24-27 sirtuin 1 Mus musculus 14-19 30930169-4 2019 Administration of the NAD(+) precursor nicotinamide mononucleotide maintains telomere length, dampens the DNA damage response and p53, improves mitochondrial function, and, functionally, rescues liver fibrosis in a partially Sirt1-dependent manner. NAD 22-28 sirtuin 1 Mus musculus 225-230 30909324-6 2019 To sum up, our data indicate a role for NMNAT2 in controlling redox homeostasis during oocyte maturation and uncover that NMNAT2- NAD+ -SIRT1 is an important pathway mediating the effects of maternal age on oocyte developmental competence. NAD 130-134 sirtuin 1 Mus musculus 136-141 30771486-3 2019 We have investigated the role of the NAD+-dependent Class III deacetylase SIRT1 in the adaptive response to MG in mouse oocytes and ovary. NAD 37-41 sirtuin 1 Mus musculus 74-79 31127273-1 2019 Sirtuin 1 (Sirt1) is an NAD-dependent class III deacetylase that functions as a cellular energy sensor. NAD 24-27 sirtuin 1 Mus musculus 0-9 31127273-1 2019 Sirtuin 1 (Sirt1) is an NAD-dependent class III deacetylase that functions as a cellular energy sensor. NAD 24-27 sirtuin 1 Mus musculus 11-16 30665027-1 2019 The activity of NAD+-dependent deacetylase Sir2, originally discovered in yeast, is known to be essential for effective longevity. NAD 16-19 sirtuin 1 Mus musculus 43-47 30665027-4 2019 The three-domain structure of Sir2 has a distinct crevice that plays an important regulatory role in the binding of NAD+. NAD 116-120 sirtuin 1 Mus musculus 30-34 30877853-1 2019 Sirtuin-1 (SirT1) catalyzes NAD+-dependent protein lysine deacetylation and is a critical regulator of energy and lipid metabolism, mitochondrial biogenesis, apoptosis, and senescence. NAD 28-31 sirtuin 1 Mus musculus 0-9 30877853-1 2019 Sirtuin-1 (SirT1) catalyzes NAD+-dependent protein lysine deacetylation and is a critical regulator of energy and lipid metabolism, mitochondrial biogenesis, apoptosis, and senescence. NAD 28-31 sirtuin 1 Mus musculus 11-16 30746504-1 2019 Sirt1 is an NAD-dependent, class III deacetylase that functions as a cellular energy sensor. NAD 12-15 sirtuin 1 Mus musculus 0-5 30295421-1 2018 SIRT1 is an NAD+ -dependent deacetylase that functions in a variety of cells and tissues to mitigate age-associated diseases. NAD 12-15 sirtuin 1 Mus musculus 0-5 30389922-3 2018 Previous studies had shown that NAD-dependent deacetylase sirtuin-1 (SIRT1) in part influences the health-promoting effects of caloric restriction by boosting fat use in peripheral tissues. NAD 32-35 sirtuin 1 Mus musculus 69-74 30291911-11 2018 In addition, a decrease in SIRT1 activity due to a reduction in the NAD+/NADH ratio by PARP-1 hyperactivation was associated with AIC through increased nuclear factor (NF)-kappaB p65 and p53 acetylation in both WT and NQO1-/- mice. NAD 68-72 sirtuin 1 Mus musculus 27-32 30291911-11 2018 In addition, a decrease in SIRT1 activity due to a reduction in the NAD+/NADH ratio by PARP-1 hyperactivation was associated with AIC through increased nuclear factor (NF)-kappaB p65 and p53 acetylation in both WT and NQO1-/- mice. NAD 73-77 sirtuin 1 Mus musculus 27-32 30291911-12 2018 While an elevation in NAD+/NADH ratio via NQO1 enzymatic action using dunnione recovered SIRT1 activity and subsequently deacetylated NF-kappaB p65 and p53, however not in NQO1-/- mice, thereby attenuating AIC. NAD 22-26 sirtuin 1 Mus musculus 89-94 30291911-12 2018 While an elevation in NAD+/NADH ratio via NQO1 enzymatic action using dunnione recovered SIRT1 activity and subsequently deacetylated NF-kappaB p65 and p53, however not in NQO1-/- mice, thereby attenuating AIC. NAD 27-31 sirtuin 1 Mus musculus 89-94 30179604-1 2018 BACKGROUND: Nicotinamide adenine dinucleotide (NAD)-dependent deacetylase SIRT1 is an important regulator of hypothalamic neuronal function. NAD 12-45 sirtuin 1 Mus musculus 74-79 30179604-1 2018 BACKGROUND: Nicotinamide adenine dinucleotide (NAD)-dependent deacetylase SIRT1 is an important regulator of hypothalamic neuronal function. NAD 47-50 sirtuin 1 Mus musculus 74-79 30179604-8 2018 Exogenous NAD suppressed NPY and AgRP transcriptional activity, which was mediated by SIRT1 and FOXO1. NAD 10-13 sirtuin 1 Mus musculus 86-91 30510631-1 2018 We previously showed that treatment with resveratrol (3,5,4"-trihydroxy-trans-stilbene), an activator of the NAD+-dependent deacetylase SIRT1 at 4 g/kg food for 32 weeks, significantly decreased the muscular reactive oxygen species (ROS) levels and ameliorated the pathology of mdx mice, an animal model of Duchenne muscular dystrophy (DMD). NAD 109-113 sirtuin 1 Mus musculus 136-141 30144531-4 2018 In HFD feeding or fasting state, hepatic gluconeogenesis and fatty acid oxidation induced SirT1 expression due to the increased nicotinamide adenine dinucleotide+ (NAD+) contents. NAD 128-161 sirtuin 1 Mus musculus 90-95 30144531-4 2018 In HFD feeding or fasting state, hepatic gluconeogenesis and fatty acid oxidation induced SirT1 expression due to the increased nicotinamide adenine dinucleotide+ (NAD+) contents. NAD 164-168 sirtuin 1 Mus musculus 90-95 30144531-5 2018 Baicalin reduces endogenous glucose production via suppression of hepatic gluconeogenesis and decreased SirT1 induction via reducing NAD+ accumulation in an energy-sensing way. NAD 133-137 sirtuin 1 Mus musculus 104-109 30228292-1 2018 The NAD+-dependent lysine deacetylase, Sirtuin 1 (SIRT1), plays a central role in metabolic regulation. NAD 4-8 sirtuin 1 Mus musculus 39-48 30228292-1 2018 The NAD+-dependent lysine deacetylase, Sirtuin 1 (SIRT1), plays a central role in metabolic regulation. NAD 4-8 sirtuin 1 Mus musculus 50-55 30021836-1 2018 The NAD+-dependent deacetylase SIRT1 can be oncogenic or tumor suppressive depending on the tissue. NAD 4-8 sirtuin 1 Mus musculus 31-36 29753648-7 2018 Using 1H-nuclear magnetic resonance metabolomic analysis, we found that the content of NAD and NMN were increased in the VTA of cocaine-conditioned mice; moreover, the expression of SIRT1 was also upregulated. NAD 87-90 sirtuin 1 Mus musculus 182-187 29753648-9 2018 Our results suggest that NAMPT-mediated NAD biosynthesis may modify cocaine behavioral effects through SIRT1. NAD 40-43 sirtuin 1 Mus musculus 103-108 29753648-10 2018 Moreover, our findings reveal that the interplay between NAD biosynthesis and SIRT1 regulation may comprise a novel regulatory pathway that responds to chronic cocaine stimuli. NAD 57-60 sirtuin 1 Mus musculus 78-83 30069485-3 2018 NAD+-sensing nuclear sirtuin1 (SIRT1) epigenetically guards immune and metabolic homeostasis during sepsis. NAD 0-4 sirtuin 1 Mus musculus 21-29 30069485-3 2018 NAD+-sensing nuclear sirtuin1 (SIRT1) epigenetically guards immune and metabolic homeostasis during sepsis. NAD 0-4 sirtuin 1 Mus musculus 31-36 30069485-8 2018 These findings support the unifying concept that nuclear NAD+ sensor SIRT1 broadly coordinates innate and adaptive immune reprogramming during sepsis and is a druggable immunometabolic enhancement target. NAD 57-61 sirtuin 1 Mus musculus 69-74 29905535-4 2018 NAD+ levels declined with age and correlated directly with decreased nicotinamide phosphoribosyltransferase (NAMPT) expression, increased expression of senescence markers (p16INK4a, p21Waf/Cip1, ApoJ, CTGF and beta-galactosidase) and significant reductions in SIRT1 expression and activity. NAD 0-4 sirtuin 1 Mus musculus 260-265 29477240-3 2018 SIRT1 encodes an NAD-dependent deacetylase that modifies the activity of key transcriptional regulators affected in diabetic kidneys, including NF-kappaB, STAT3, p53, FOXO4, and PGC1-alpha. NAD 17-20 sirtuin 1 Mus musculus 0-5 29892266-4 2018 Sirtuin 1 (SIRT1) is a protein deacetylase depended on nicotinamide adenine dinucleotide. NAD 55-88 sirtuin 1 Mus musculus 0-9 29892266-4 2018 Sirtuin 1 (SIRT1) is a protein deacetylase depended on nicotinamide adenine dinucleotide. NAD 55-88 sirtuin 1 Mus musculus 11-16 29977153-8 2018 However, re-expression of CD38 in the knockdown clones reversed the effect on Sirt1/NF-kappaB/TLR2 signaling, which is NAD-dependent. NAD 119-122 sirtuin 1 Mus musculus 78-83 29782205-6 2018 We linked this lack of therapeutic effect to NAD+-independent activation of SIRT-1 and -3 via AMPK and cAMP signaling related to the starvation-like metabolic state of Bcs1lp.S78G mice. NAD 45-49 sirtuin 1 Mus musculus 76-89 29550483-9 2018 GR24 upregulated SIRT1 and enhanced the production of NAD+, an essential SIRT1 substrate. NAD 54-58 sirtuin 1 Mus musculus 73-78 29409011-14 2018 Conclusions: Cardiac SIRT1 mediates AMPK activation via LKB1 deacetylation, and AMPK modulates SIRT1 activity via regulation of NAD+ level during ischaemia. NAD 128-132 sirtuin 1 Mus musculus 95-100 29570999-5 2018 Treatment of mice with the NAD+ booster nicotinamide mononucleotide (NMN) improves blood flow and increases endurance in elderly mice by promoting SIRT1-dependent increases in capillary density, an effect augmented by exercise or increasing the levels of hydrogen sulfide (H2S), a DR mimetic and regulator of endothelial NAD+ levels. NAD 27-31 sirtuin 1 Mus musculus 147-152 29570999-5 2018 Treatment of mice with the NAD+ booster nicotinamide mononucleotide (NMN) improves blood flow and increases endurance in elderly mice by promoting SIRT1-dependent increases in capillary density, an effect augmented by exercise or increasing the levels of hydrogen sulfide (H2S), a DR mimetic and regulator of endothelial NAD+ levels. NAD 321-325 sirtuin 1 Mus musculus 147-152 29402742-1 2018 The NAD+-dependent deacetylase SIRT1, which is associated with the improvement of metabolic syndromes, such as type 2 diabetes, is a well-known longevity-related gene. NAD 4-8 sirtuin 1 Mus musculus 31-36 29405961-2 2018 Sirtuin-1 (Sirt1) is a ubiquitously-expressed NAD-dependent protein deacetylase which plays a key role in numerous cellular processes, including cellular differentiation and metabolism. NAD 46-49 sirtuin 1 Mus musculus 0-9 29405961-2 2018 Sirtuin-1 (Sirt1) is a ubiquitously-expressed NAD-dependent protein deacetylase which plays a key role in numerous cellular processes, including cellular differentiation and metabolism. NAD 46-49 sirtuin 1 Mus musculus 11-16 29433736-5 2018 Deacetylation of FoxOs by the NAD-dependent histone deacetylase Sirt1 in both osteoblasts and osteoclasts stimulates bone formation and inhibits bone resorption, making Sirt1 activators promising therapeutic agents for diseases of low bone mass. NAD 30-33 sirtuin 1 Mus musculus 64-69 29433736-5 2018 Deacetylation of FoxOs by the NAD-dependent histone deacetylase Sirt1 in both osteoblasts and osteoclasts stimulates bone formation and inhibits bone resorption, making Sirt1 activators promising therapeutic agents for diseases of low bone mass. NAD 30-33 sirtuin 1 Mus musculus 169-174 29185343-8 2017 Our results suggest that PQQ-inducible mitochondrial biogenesis can be attributed to activation of the SIRT1/PGC-1alpha signaling pathway by enhancing cellular NAD+ formation. NAD 160-164 sirtuin 1 Mus musculus 103-108 29423066-3 2018 Silent information regulator transcript-1 (SIRT1), an NAD-dependent deacetylase, inhibits the release of inflammatory cytokines. NAD 54-57 sirtuin 1 Mus musculus 43-48 28544355-1 2017 AIMS: Activation of the NAD+ dependent protein deacetylase SIRT1 has been proposed as a therapeutic strategy to treat mitochondrial dysfunction and insulin resistance in skeletal muscle. NAD 24-27 sirtuin 1 Mus musculus 59-64 31966440-2 2017 The aim of the present study was to investigate whether the protective effects of propofol on the liver are related to Sirt1, an NAD+-dependent deacetylase with anti-inflammatory and antioxidant properties. NAD 129-132 sirtuin 1 Mus musculus 119-124 29074993-1 2017 Sirtuins (SIRT1-7) are NAD-dependent proteins with the enzymatic activity of deacetylases and ADP ribosyltransferases. NAD 23-26 sirtuin 1 Mus musculus 10-15 28970491-6 2017 We conclude that replication stress via Rev1-deficiency contributes to metabolic stress caused by compromized mitochondrial function via the PARP-NAD+-SIRT1-PGC1alpha axis. NAD 146-150 sirtuin 1 Mus musculus 151-156 28973994-1 2017 Nicotinamide adenine dinucleotide (NAD+) homeostasis is emerging as a key player in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and is tightly linked to the SIRT1/5"-AMP-activated protein kinase (AMPK) pathway. NAD 0-33 sirtuin 1 Mus musculus 175-180 28973994-1 2017 Nicotinamide adenine dinucleotide (NAD+) homeostasis is emerging as a key player in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and is tightly linked to the SIRT1/5"-AMP-activated protein kinase (AMPK) pathway. NAD 35-39 sirtuin 1 Mus musculus 175-180 28950020-6 2017 These findings are consistent with the TQ-dependent re-oxidation of NADH to NAD+, which stimulates glucose and fatty acid oxidation and activation of SIRT-1-dependent pathways. NAD 68-72 sirtuin 1 Mus musculus 150-156 28950020-6 2017 These findings are consistent with the TQ-dependent re-oxidation of NADH to NAD+, which stimulates glucose and fatty acid oxidation and activation of SIRT-1-dependent pathways. NAD 76-80 sirtuin 1 Mus musculus 150-156 27590140-1 2017 Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+)-dependent lysine deacetylase that regulates longevity and enhances mitochondrial metabolism. NAD 23-56 sirtuin 1 Mus musculus 0-9 27590140-1 2017 Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+)-dependent lysine deacetylase that regulates longevity and enhances mitochondrial metabolism. NAD 23-56 sirtuin 1 Mus musculus 11-16 27590140-1 2017 Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+)-dependent lysine deacetylase that regulates longevity and enhances mitochondrial metabolism. NAD 58-62 sirtuin 1 Mus musculus 0-9 27590140-1 2017 Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD+)-dependent lysine deacetylase that regulates longevity and enhances mitochondrial metabolism. NAD 58-62 sirtuin 1 Mus musculus 11-16 29137352-6 2017 The mitochondrial dysfunction-associated senescence in pups was accompanied by a drop in NAD+/NADH ratio and alteration in the NAD+-dependent enzymes PARP1 and SIRT1. NAD 127-131 sirtuin 1 Mus musculus 160-165 28246130-0 2017 Nicotinamide Mononucleotide, an NAD+ Precursor, Rescues Age-Associated Susceptibility to AKI in a Sirtuin 1-Dependent Manner. NAD 32-36 sirtuin 1 Mus musculus 98-107 28246130-3 2017 In this study, we found that, compared with the kidneys of 3-month-old mice, the kidneys of 20-month-old mice expressed reduced levels of the renal protective molecule sirtuin 1 (SIRT1) and its cofactor NAD+ Supplementation with nicotinamide mononucleotide (NMN), an NAD+ precursor, restored renal SIRT1 activity and NAD+ content in 20-month-old mice and further increased both in 3-month-old mice. NAD 267-271 sirtuin 1 Mus musculus 168-177 28246130-3 2017 In this study, we found that, compared with the kidneys of 3-month-old mice, the kidneys of 20-month-old mice expressed reduced levels of the renal protective molecule sirtuin 1 (SIRT1) and its cofactor NAD+ Supplementation with nicotinamide mononucleotide (NMN), an NAD+ precursor, restored renal SIRT1 activity and NAD+ content in 20-month-old mice and further increased both in 3-month-old mice. NAD 267-271 sirtuin 1 Mus musculus 179-184 28246130-3 2017 In this study, we found that, compared with the kidneys of 3-month-old mice, the kidneys of 20-month-old mice expressed reduced levels of the renal protective molecule sirtuin 1 (SIRT1) and its cofactor NAD+ Supplementation with nicotinamide mononucleotide (NMN), an NAD+ precursor, restored renal SIRT1 activity and NAD+ content in 20-month-old mice and further increased both in 3-month-old mice. NAD 267-271 sirtuin 1 Mus musculus 168-177 28246130-3 2017 In this study, we found that, compared with the kidneys of 3-month-old mice, the kidneys of 20-month-old mice expressed reduced levels of the renal protective molecule sirtuin 1 (SIRT1) and its cofactor NAD+ Supplementation with nicotinamide mononucleotide (NMN), an NAD+ precursor, restored renal SIRT1 activity and NAD+ content in 20-month-old mice and further increased both in 3-month-old mice. NAD 267-271 sirtuin 1 Mus musculus 179-184 28537485-3 2017 Decreased NAD+ levels with age reduce SIRT1 function and reduce the mitochondrial unfolded protein response, which can be overcome by NR supplementation. NAD 10-14 sirtuin 1 Mus musculus 38-43 28537485-9 2017 The NAD+/PARP1/SIRT1 axis may link NAD+ levels and DNA damage with the apparent epigenomic DNA methylation clocks that have been described. NAD 4-8 sirtuin 1 Mus musculus 15-20 28537485-9 2017 The NAD+/PARP1/SIRT1 axis may link NAD+ levels and DNA damage with the apparent epigenomic DNA methylation clocks that have been described. NAD 35-39 sirtuin 1 Mus musculus 15-20 27460777-2 2017 Currently, only the mitochondrial sirtuins (SIRT3-5) and SIRT1 have been shown to direct mitochondrial function; however, Aims: NAD-dependent protein deacetylase sirtuin-2 (SIRT2), the primary cytoplasmic sirtuin, is not yet reported to associate with mitochondria. NAD 128-131 sirtuin 1 Mus musculus 57-62 28533555-3 2017 Scopolin decreased the Km of SIRT1 for p53 and nicotinamide adenine dinucleotide without altering Vmax in a cell-free system. NAD 47-80 sirtuin 1 Mus musculus 29-34 28434941-3 2017 Here, we report that a spectrum of environmental stresses, including oxidative stress, starvation, and DNA damage, profoundly activate SIRT1, an NAD+-dependent lysine deacetylase. NAD 145-149 sirtuin 1 Mus musculus 135-140 28881659-1 2017 SIRT1, a highly conserved NAD+-dependent protein deacetylase, plays a pivotal role in the pathogenesis and therapy of atherosclerosis (AS). NAD 26-29 sirtuin 1 Mus musculus 0-5 28239158-10 2017 Further studies revealed that treatment with 6014 did not affect the expression levels of PARP-1, but dose-dependently inhibited the activity of PARP-1 and subsequently restored the activity of SIRT-1 in heart tissues due to the decreased consumption of NAD+ and attenuated Poly-ADP-ribosylation (PARylation) of SIRT-1. NAD 254-258 sirtuin 1 Mus musculus 194-200 28254441-6 2017 Moreover, the EPA+DHA mixture activated SIRT1 signaling by enhancing mRNA level of nicotinamide phosphoribosyltransferase (NAMPT), cellular NAD+ level, SIRT1 protein deacetylase activity, and SIRT1 mRNA levels in LPS-stimulated MG6. NAD 140-144 sirtuin 1 Mus musculus 40-45 28074060-9 2017 Novel common pathways including increased induction of an NAD+-dependent protein deacetylase sirtuin-1 that may reduce NF-kappaB signalling, and increased STAT3 activation may reduce LPS activation. NAD 58-62 sirtuin 1 Mus musculus 93-102 28449683-14 2017 On the one hand, the inhibition of NAMPT reduced the production of NAD+ through inhibiting the NAD+ salvage pathway, resulting in the decrease of Sirt1 activity, and then attenuated the deacetylation of SREBP1 in which the inhibition of SREBP1 activity promoted the expressions of FASN and ACC. NAD 67-71 sirtuin 1 Mus musculus 146-151 28449683-14 2017 On the one hand, the inhibition of NAMPT reduced the production of NAD+ through inhibiting the NAD+ salvage pathway, resulting in the decrease of Sirt1 activity, and then attenuated the deacetylation of SREBP1 in which the inhibition of SREBP1 activity promoted the expressions of FASN and ACC. NAD 95-99 sirtuin 1 Mus musculus 146-151 28533928-1 2017 BACKGROUND/AIMS: Nicotinic acid (NA), a lipid-lowering drug, serves as a source of NAD+, the cofactor for Sirt1. NAD 83-87 sirtuin 1 Mus musculus 106-111 28377411-4 2017 We showed that Sirtuin 1 (Sirt1), which is an NAD+ (nicotinamide adenine dinucleotide)-dependent lysine deacetylase that inhibits NIC-dependent gene transcription, stabilized NIC proximal to the plasma membrane to promote the survival and function of activated Treg cells. NAD 46-50 sirtuin 1 Mus musculus 15-24 28377411-4 2017 We showed that Sirtuin 1 (Sirt1), which is an NAD+ (nicotinamide adenine dinucleotide)-dependent lysine deacetylase that inhibits NIC-dependent gene transcription, stabilized NIC proximal to the plasma membrane to promote the survival and function of activated Treg cells. NAD 46-50 sirtuin 1 Mus musculus 26-31 28377411-4 2017 We showed that Sirtuin 1 (Sirt1), which is an NAD+ (nicotinamide adenine dinucleotide)-dependent lysine deacetylase that inhibits NIC-dependent gene transcription, stabilized NIC proximal to the plasma membrane to promote the survival and function of activated Treg cells. NAD 52-85 sirtuin 1 Mus musculus 15-24 28377411-4 2017 We showed that Sirtuin 1 (Sirt1), which is an NAD+ (nicotinamide adenine dinucleotide)-dependent lysine deacetylase that inhibits NIC-dependent gene transcription, stabilized NIC proximal to the plasma membrane to promote the survival and function of activated Treg cells. NAD 52-85 sirtuin 1 Mus musculus 26-31 28270525-2 2017 The NAD+-dependent deacetylase SIRT1 serves as a guardian against metabolic disorders in multiple tissues. NAD 4-8 sirtuin 1 Mus musculus 31-36 30090498-2 2017 SIRT1, a NAD+-dependent histone deacetylase, can play a neuroprotective role in brain injury. NAD 9-12 sirtuin 1 Mus musculus 0-5 27474445-2 2017 SIRT1, a NAD dependent protein deacetylase, has been implicated in the pathogenesis of neurodegeneration in neurological diseases including MS. We have studied the role of SIRT1 in experimental autoimmune encephalomyelitis (EAE) and found evidence for a neuroprotective role. NAD 9-12 sirtuin 1 Mus musculus 0-5 28707004-3 2017 We show that Mtb down-regulates sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, in monocytes/macrophages, TB animal models, and TB patients with active disease. NAD 53-86 sirtuin 1 Mus musculus 43-48 28707004-3 2017 We show that Mtb down-regulates sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, in monocytes/macrophages, TB animal models, and TB patients with active disease. NAD 88-91 sirtuin 1 Mus musculus 43-48 28228259-2 2017 Here, we show that the nicotinamide adenine dinucleotide (NAD)-dependent deacetylase, Sirt1, selectively prevents abnormal DNA methylation of some developmental genes in murine ESCs by antagonizing Dnmt3l. NAD 23-56 sirtuin 1 Mus musculus 86-91 28228259-2 2017 Here, we show that the nicotinamide adenine dinucleotide (NAD)-dependent deacetylase, Sirt1, selectively prevents abnormal DNA methylation of some developmental genes in murine ESCs by antagonizing Dnmt3l. NAD 58-61 sirtuin 1 Mus musculus 86-91 27911441-3 2017 Here, we tested whether sirtuin-1 (SIRT1), a NAD+-dependent deacetylase, participates in modulating ER stress response in the heart. NAD 45-48 sirtuin 1 Mus musculus 24-33 27911441-3 2017 Here, we tested whether sirtuin-1 (SIRT1), a NAD+-dependent deacetylase, participates in modulating ER stress response in the heart. NAD 45-48 sirtuin 1 Mus musculus 35-40 28122227-5 2017 Reduced p53 activity in HFD-fed Mdm2C305F/C305F mice resulted in higher levels of p53 downregulated targets GLUT4 and SIRT1, leading to increased biosynthesis of NAD+, and increased energy expenditure. NAD 162-166 sirtuin 1 Mus musculus 118-123 29393101-1 2017 The sirtuin SIRT1 is a highly conserved nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylase known to have protective effects against a wide range of neurological disorders. NAD 40-73 sirtuin 1 Mus musculus 12-17 29393101-1 2017 The sirtuin SIRT1 is a highly conserved nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylase known to have protective effects against a wide range of neurological disorders. NAD 75-78 sirtuin 1 Mus musculus 12-17 27683265-6 2016 Immunohistochemistry of NAD+-dependent deacetylase SIRTUIN 1 (SIRT1) in neonatal ovary revealed that increasing SIRT1 expression in oocyte nuclei was inversely related to decreasing free/bound NADH during the primordial to primary follicle transition. NAD 24-28 sirtuin 1 Mus musculus 51-60 27683265-6 2016 Immunohistochemistry of NAD+-dependent deacetylase SIRTUIN 1 (SIRT1) in neonatal ovary revealed that increasing SIRT1 expression in oocyte nuclei was inversely related to decreasing free/bound NADH during the primordial to primary follicle transition. NAD 24-28 sirtuin 1 Mus musculus 62-67 27683265-6 2016 Immunohistochemistry of NAD+-dependent deacetylase SIRTUIN 1 (SIRT1) in neonatal ovary revealed that increasing SIRT1 expression in oocyte nuclei was inversely related to decreasing free/bound NADH during the primordial to primary follicle transition. NAD 24-28 sirtuin 1 Mus musculus 112-117 27683265-6 2016 Immunohistochemistry of NAD+-dependent deacetylase SIRTUIN 1 (SIRT1) in neonatal ovary revealed that increasing SIRT1 expression in oocyte nuclei was inversely related to decreasing free/bound NADH during the primordial to primary follicle transition. NAD 193-197 sirtuin 1 Mus musculus 51-60 27683265-6 2016 Immunohistochemistry of NAD+-dependent deacetylase SIRTUIN 1 (SIRT1) in neonatal ovary revealed that increasing SIRT1 expression in oocyte nuclei was inversely related to decreasing free/bound NADH during the primordial to primary follicle transition. NAD 193-197 sirtuin 1 Mus musculus 62-67 27683265-6 2016 Immunohistochemistry of NAD+-dependent deacetylase SIRTUIN 1 (SIRT1) in neonatal ovary revealed that increasing SIRT1 expression in oocyte nuclei was inversely related to decreasing free/bound NADH during the primordial to primary follicle transition. NAD 193-197 sirtuin 1 Mus musculus 112-117 27771463-1 2016 Silent mating type information regulation 2 homolog 1 (SIRT1), a NAD-dependent deacetylase, mediates cellular processes involved in gene silencing and aging. NAD 65-68 sirtuin 1 Mus musculus 55-60 29442004-2 2016 Sirt-1, an NAD+ dependent deacetylase, regulates a variety of cellular processes, including aging, lifespan extension and glucose and lipid metabolism. NAD 11-14 sirtuin 1 Mus musculus 0-6 27687729-5 2016 The synergistic increase in nuclear p53 and FOXO3 by exercise can facilitate their known interaction in transactivating Sirtuin 1 (SIRT1), a NAD+-dependent histone deacetylase that mediates adaptation to various stresses. NAD 141-145 sirtuin 1 Mus musculus 120-129 27687729-5 2016 The synergistic increase in nuclear p53 and FOXO3 by exercise can facilitate their known interaction in transactivating Sirtuin 1 (SIRT1), a NAD+-dependent histone deacetylase that mediates adaptation to various stresses. NAD 141-145 sirtuin 1 Mus musculus 131-136 27456392-1 2016 BACKGROUND: We have previously shown leucine (Leu) to activate Sirt1 by lowering its KM for NAD+, thereby amplifying the effects of other sirtuin activators and improving insulin sensitivity. NAD 92-96 sirtuin 1 Mus musculus 63-68 27456392-6 2016 RESULTS: Leu (0.5mmol/L)+Met (50-100mumol/L) synergistically activated Sirt1 (p<0.001) at low (<=100mumol/L) NAD+ levels while Met exerted no independent effect. NAD 115-119 sirtuin 1 Mus musculus 71-76 27456392-12 2016 CONCLUSION: Thus, Leu and Met synergize to enable Sirt1 activation at low NAD+ concentrations (typical of energy replete states). NAD 74-78 sirtuin 1 Mus musculus 50-55 27552971-2 2016 Mice engineered to express additional copies of SIRT1 or SIRT6, or treated with sirtuin-activating compounds (STACs) such as resveratrol and SRT2104 or with NAD+ precursors, have improved organ function, physical endurance, disease resistance and longevity. NAD 157-161 sirtuin 1 Mus musculus 48-53 27764779-4 2016 In this study, we investigated the effect of MSCs overexpressing an NAD-dependent deacetylase sirtuin 1 (MSCs-Sirt1) on prostate tumor growth, and we analyzed the underlying mechanisms. NAD 68-71 sirtuin 1 Mus musculus 110-115 27732834-0 2016 Overcoming ATM Deficiency by Activating the NAD+/SIRT1 Axis. NAD 44-48 sirtuin 1 Mus musculus 49-54 27732834-3 2016 This broad suppression by activating the NAD+/SIRT1 axis may generally apply to diseases and aging maladies. NAD 41-45 sirtuin 1 Mus musculus 46-51 27500459-0 2016 Treatment with NAD(+) inhibited experimental autoimmune encephalomyelitis by activating AMPK/SIRT1 signaling pathway and modulating Th1/Th17 immune responses in mice. NAD 15-21 sirtuin 1 Mus musculus 93-98 27500459-7 2016 We also found that the AMP-activated protein kinase (AMPK)/silent mating-type information regulation 2 homolog 1(SIRT1) pathway was activated in the NAD(+)-treated mice and NAD(+) treatment suppressed pro-inflammatory T cell responses. NAD 149-155 sirtuin 1 Mus musculus 113-118 27500459-7 2016 We also found that the AMP-activated protein kinase (AMPK)/silent mating-type information regulation 2 homolog 1(SIRT1) pathway was activated in the NAD(+)-treated mice and NAD(+) treatment suppressed pro-inflammatory T cell responses. NAD 173-179 sirtuin 1 Mus musculus 113-118 27378422-3 2016 Sirtuin1 (Sirt1) is a nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase, which is reported to be involved in improving osteogenesis. NAD 22-55 sirtuin 1 Mus musculus 0-8 27378422-3 2016 Sirtuin1 (Sirt1) is a nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase, which is reported to be involved in improving osteogenesis. NAD 22-55 sirtuin 1 Mus musculus 10-15 27378422-3 2016 Sirtuin1 (Sirt1) is a nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase, which is reported to be involved in improving osteogenesis. NAD 57-61 sirtuin 1 Mus musculus 0-8 27378422-3 2016 Sirtuin1 (Sirt1) is a nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase, which is reported to be involved in improving osteogenesis. NAD 57-61 sirtuin 1 Mus musculus 10-15 27339462-0 2016 alpha7 Nicotinic Acetylcholine Receptor Relieves Angiotensin II-Induced Senescence in Vascular Smooth Muscle Cells by Raising Nicotinamide Adenine Dinucleotide-Dependent SIRT1 Activity. NAD 126-159 sirtuin 1 Mus musculus 170-175 27339462-11 2016 CONCLUSIONS: Our results demonstrate that activation of alpha7nAChR alleviates Ang II-induced VSMC senescence through promoting NAD(+)-SIRT1 pathway, suggesting that alpha7nAChR may be a potential therapeutic target for the treatment of Ang II-associated vascular aging disorders. NAD 128-134 sirtuin 1 Mus musculus 135-140 27404390-5 2016 During ethanol metabolism, a low NAD(+)/NADH ratio repressed NAD-dependent deacetylase sirtuin 1 (SIRT1) activity, concomitantly resulting in increased acetylated PPARgamma with high transcriptional activity. NAD 33-39 sirtuin 1 Mus musculus 87-96 27404390-5 2016 During ethanol metabolism, a low NAD(+)/NADH ratio repressed NAD-dependent deacetylase sirtuin 1 (SIRT1) activity, concomitantly resulting in increased acetylated PPARgamma with high transcriptional activity. NAD 33-39 sirtuin 1 Mus musculus 98-103 27404390-5 2016 During ethanol metabolism, a low NAD(+)/NADH ratio repressed NAD-dependent deacetylase sirtuin 1 (SIRT1) activity, concomitantly resulting in increased acetylated PPARgamma with high transcriptional activity. NAD 40-44 sirtuin 1 Mus musculus 87-96 27404390-5 2016 During ethanol metabolism, a low NAD(+)/NADH ratio repressed NAD-dependent deacetylase sirtuin 1 (SIRT1) activity, concomitantly resulting in increased acetylated PPARgamma with high transcriptional activity. NAD 40-44 sirtuin 1 Mus musculus 98-103 27404390-5 2016 During ethanol metabolism, a low NAD(+)/NADH ratio repressed NAD-dependent deacetylase sirtuin 1 (SIRT1) activity, concomitantly resulting in increased acetylated PPARgamma with high transcriptional activity. NAD 33-36 sirtuin 1 Mus musculus 87-96 27404390-5 2016 During ethanol metabolism, a low NAD(+)/NADH ratio repressed NAD-dependent deacetylase sirtuin 1 (SIRT1) activity, concomitantly resulting in increased acetylated PPARgamma with high transcriptional activity. NAD 33-36 sirtuin 1 Mus musculus 98-103 27085036-3 2016 Autophagy is regulated by silent information regulator-1 (SIRT1), a NAD+-dependent histone deacetylase. NAD 68-71 sirtuin 1 Mus musculus 26-56 27085036-3 2016 Autophagy is regulated by silent information regulator-1 (SIRT1), a NAD+-dependent histone deacetylase. NAD 68-71 sirtuin 1 Mus musculus 58-63 27313401-6 2016 AMPK activation increased the NAD(+)/NADH ratio and activated Sirtuin 1 (SIRT1), a NAD(+)-dependent deacetylating enzyme and negative regulator of inflammation. NAD 83-89 sirtuin 1 Mus musculus 62-71 27313401-6 2016 AMPK activation increased the NAD(+)/NADH ratio and activated Sirtuin 1 (SIRT1), a NAD(+)-dependent deacetylating enzyme and negative regulator of inflammation. NAD 83-89 sirtuin 1 Mus musculus 73-78 27423864-1 2016 The NAD(+)-dependent deacetylase SIRT1 plays key roles in numerous cellular processes including DNA repair, gene transcription, cell differentiation, and metabolism. NAD 4-10 sirtuin 1 Mus musculus 33-38 27073590-5 2016 SIRT1 is an NAD(+)-dependent histone/protein deacetylase that plays roles in diverse cellular processes, including stress resistance and cell survival. NAD 12-18 sirtuin 1 Mus musculus 0-5 26522369-5 2015 Pharmacological inhibition of Nampt by FK866 or depletion of monocytes/macrophages by clodronate liposomes disrupted the homeostatic mechanism of myocardial NAD(+) levels and NAD(+)-dependent Sirt1 activity, leading to susceptibility to cardiomyocyte apoptosis and cardiac decompensation in pressure-overloaded mice. NAD 175-181 sirtuin 1 Mus musculus 192-197 25761756-8 2015 While the expression and activity of the NAD(+) dependent deacetylase sirtuin 1, a ChREBP-negative target, were down-regulated in the liver of alcohol-fed mice, they were restored to control levels upon ChREBP silencing. NAD 41-47 sirtuin 1 Mus musculus 70-79 26287518-1 2015 Activation of Sirtuin1 (Sirt1), an nicotinamide adenine dinucleotide oxidized-dependent deacetylase, by natural or synthetic compounds like resveratrol, SRT2104, or SRT3025 attenuates the loss of bone mass caused by ovariectomy, aging, or unloading in mice. NAD 35-68 sirtuin 1 Mus musculus 14-22 26287518-1 2015 Activation of Sirtuin1 (Sirt1), an nicotinamide adenine dinucleotide oxidized-dependent deacetylase, by natural or synthetic compounds like resveratrol, SRT2104, or SRT3025 attenuates the loss of bone mass caused by ovariectomy, aging, or unloading in mice. NAD 35-68 sirtuin 1 Mus musculus 24-29 26376991-1 2015 BACKGROUND: Sirtuin-1 (SirT1), a nicotinamide adenine dinucleotide(+)-dependent deacetylase, is a key enzyme in the cellular response to metabolic, inflammatory, and oxidative stresses; however, the role of endogenous SirT1 in the vasculature has not been fully elucidated. NAD 33-66 sirtuin 1 Mus musculus 12-21 26376991-1 2015 BACKGROUND: Sirtuin-1 (SirT1), a nicotinamide adenine dinucleotide(+)-dependent deacetylase, is a key enzyme in the cellular response to metabolic, inflammatory, and oxidative stresses; however, the role of endogenous SirT1 in the vasculature has not been fully elucidated. NAD 33-66 sirtuin 1 Mus musculus 23-28 26376991-1 2015 BACKGROUND: Sirtuin-1 (SirT1), a nicotinamide adenine dinucleotide(+)-dependent deacetylase, is a key enzyme in the cellular response to metabolic, inflammatory, and oxidative stresses; however, the role of endogenous SirT1 in the vasculature has not been fully elucidated. NAD 33-66 sirtuin 1 Mus musculus 218-223 26033245-5 2015 Enhanced NAD levels were associated with deacetylation of p53 and Nfkappab indicating increased activation of Sirt1. NAD 9-12 sirtuin 1 Mus musculus 110-115 25858853-2 2015 Leucine (Leu) activates Sirt1 by lowering its Km for NAD(+) and potentiates other sirtuin/AMPK-activators, resulting in improvement of insulin sensitivity. NAD 53-59 sirtuin 1 Mus musculus 24-29 26060246-10 2015 Knockdown of NAD-dependent deacetylase sirtuin 1 (SIRT1) and SIRT2 inhibited the progrowth action of Nampt-NAD axis, whereas knockdown of SIRT1, SIRT2, and SIRT6 compromised the prodifferentiation effect of Nampt-NAD axis. NAD 13-16 sirtuin 1 Mus musculus 50-55 26060246-10 2015 Knockdown of NAD-dependent deacetylase sirtuin 1 (SIRT1) and SIRT2 inhibited the progrowth action of Nampt-NAD axis, whereas knockdown of SIRT1, SIRT2, and SIRT6 compromised the prodifferentiation effect of Nampt-NAD axis. NAD 107-110 sirtuin 1 Mus musculus 50-55 26060246-10 2015 Knockdown of NAD-dependent deacetylase sirtuin 1 (SIRT1) and SIRT2 inhibited the progrowth action of Nampt-NAD axis, whereas knockdown of SIRT1, SIRT2, and SIRT6 compromised the prodifferentiation effect of Nampt-NAD axis. NAD 107-110 sirtuin 1 Mus musculus 50-55 26074075-2 2015 The NAD(+)-dependent deacetylase SirT1 orchestrates metabolism, cellular survival, and growth. NAD 4-10 sirtuin 1 Mus musculus 33-38 26098879-3 2015 Sirtuin1 (SIRT1) belongs to the family of NAD-dependent de-acyetylases and is modulated by cellular redox. NAD 42-45 sirtuin 1 Mus musculus 0-8 26098879-3 2015 Sirtuin1 (SIRT1) belongs to the family of NAD-dependent de-acyetylases and is modulated by cellular redox. NAD 42-45 sirtuin 1 Mus musculus 10-15 25921090-0 2015 SIRT1-Mediated eNAMPT Secretion from Adipose Tissue Regulates Hypothalamic NAD+ and Function in Mice. NAD 75-79 sirtuin 1 Mus musculus 0-5 25938585-3 2015 Sirtuins are a family of seven NAD+-dependent deacetylases (Sirt1-7), which are involved in multiple cellular processes and are emerging as important regulators in oocytes and embryos. NAD 31-34 sirtuin 1 Mus musculus 60-67 25475438-2 2015 SIRT1 is a NAD-dependent protein deacetylase possessing antiaging activities in a wide range of organisms. NAD 11-14 sirtuin 1 Mus musculus 0-5 25722455-4 2015 Elevated matrix NADH, in turn, diminished the cytosolic NAD(+)/NADH ratio and triggered a subsequent downregulation of the NAD(+)-dependent deacetylase sirtuin 1 (SIRT1). NAD 16-20 sirtuin 1 Mus musculus 163-168 25722455-4 2015 Elevated matrix NADH, in turn, diminished the cytosolic NAD(+)/NADH ratio and triggered a subsequent downregulation of the NAD(+)-dependent deacetylase sirtuin 1 (SIRT1). NAD 123-129 sirtuin 1 Mus musculus 163-168 25772354-1 2015 The NAD+-dependent protein deacetylase SIRT1 regulates energy metabolism, responses to stress, and aging by deacetylating many different proteins, including histones and transcription factors. NAD 4-8 sirtuin 1 Mus musculus 39-44 25517228-8 2015 By utilizing an NAD(+)-based mechanism, PARP1 inhibition increases the activity of SIRT1. NAD 16-22 sirtuin 1 Mus musculus 83-88 25600643-0 2015 The NAD(+)-dependent SIRT1 deacetylase translates a metabolic switch into regulatory epigenetics in skeletal muscle stem cells. NAD 4-10 sirtuin 1 Mus musculus 21-26 26558285-5 2015 Finally, low sirtuin-1 and sirtuin-3 gene expressions due to higher NADH/NAD in Cmah-null mice decreased Foxo-1 and MnSOD gene expression, suggesting that oxidative stress may result in mitochondrial dysfunction in Cmah-null mouse. NAD 68-72 sirtuin 1 Mus musculus 13-22 26558285-5 2015 Finally, low sirtuin-1 and sirtuin-3 gene expressions due to higher NADH/NAD in Cmah-null mice decreased Foxo-1 and MnSOD gene expression, suggesting that oxidative stress may result in mitochondrial dysfunction in Cmah-null mouse. NAD 68-71 sirtuin 1 Mus musculus 13-22 25341895-0 2014 Intracellular NAMPT-NAD+-SIRT1 cascade improves post-ischaemic vascular repair by modulating Notch signalling in endothelial progenitors. NAD 20-24 sirtuin 1 Mus musculus 25-30 25341895-11 2014 CONCLUSIONS: These results demonstrate that intracellular NAMPT-NAD(+)-SIRT1 cascade improves post-ischaemic neovascularization. NAD 64-70 sirtuin 1 Mus musculus 71-76 24496572-6 2014 Calorie restriction increases the intracellular levels of the essential pyridine nucleotide, nicotinamide adenine dinucleotide (NAD(+)), a co-substrate for the sirtuin 1 (Sirt1, silent mating-type information regulator 2 homolog 1) activity and a cofactor for oxidative phosphorylation and ATP synthesis. NAD 93-126 sirtuin 1 Mus musculus 160-169 24496572-6 2014 Calorie restriction increases the intracellular levels of the essential pyridine nucleotide, nicotinamide adenine dinucleotide (NAD(+)), a co-substrate for the sirtuin 1 (Sirt1, silent mating-type information regulator 2 homolog 1) activity and a cofactor for oxidative phosphorylation and ATP synthesis. NAD 93-126 sirtuin 1 Mus musculus 171-176 24496572-6 2014 Calorie restriction increases the intracellular levels of the essential pyridine nucleotide, nicotinamide adenine dinucleotide (NAD(+)), a co-substrate for the sirtuin 1 (Sirt1, silent mating-type information regulator 2 homolog 1) activity and a cofactor for oxidative phosphorylation and ATP synthesis. NAD 128-134 sirtuin 1 Mus musculus 160-169 24496572-6 2014 Calorie restriction increases the intracellular levels of the essential pyridine nucleotide, nicotinamide adenine dinucleotide (NAD(+)), a co-substrate for the sirtuin 1 (Sirt1, silent mating-type information regulator 2 homolog 1) activity and a cofactor for oxidative phosphorylation and ATP synthesis. NAD 128-134 sirtuin 1 Mus musculus 171-176 24496572-8 2014 The NAD(+)-dependent histone deacetylase, Sirt1, has been implicated in the ageing process. NAD 4-8 sirtuin 1 Mus musculus 42-47 25429139-6 2014 Hypoxia produced PARP1-dependent depletion of nicotinamide adenine dinucleotide (NAD(+)) and inhibition of the NAD(+)-dependent class III histone deactelyase (HDAC) sirtuin-1 (SIRT1). NAD 111-117 sirtuin 1 Mus musculus 165-174 25440059-0 2014 A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome. NAD 20-26 sirtuin 1 Mus musculus 36-41 25001863-6 2014 We tested this concept in septic mice, using the highly specific SIRT1 inhibitor EX-527, a small molecule that closes the NAD+ binding site of SIRT1. NAD 122-126 sirtuin 1 Mus musculus 65-70 25001863-6 2014 We tested this concept in septic mice, using the highly specific SIRT1 inhibitor EX-527, a small molecule that closes the NAD+ binding site of SIRT1. NAD 122-126 sirtuin 1 Mus musculus 143-148 25001863-11 2014 Our findings reveal that modifying the SIRT1 NAD+ axis may provide a novel way to treat sepsis in its hypoinflammatory phase. NAD 45-49 sirtuin 1 Mus musculus 39-44 25108014-1 2014 Cardiac overexpression of locally acting muscle-restricted (m)IGF-1 and the consequent downstream activation of NAD(+)-dependent protein deacetylase sirtuin 1 (SIRT1) trigger potent cardiac antioxidative and antihypertrophic effects. NAD 112-118 sirtuin 1 Mus musculus 149-158 25108014-1 2014 Cardiac overexpression of locally acting muscle-restricted (m)IGF-1 and the consequent downstream activation of NAD(+)-dependent protein deacetylase sirtuin 1 (SIRT1) trigger potent cardiac antioxidative and antihypertrophic effects. NAD 112-118 sirtuin 1 Mus musculus 160-165 25044690-3 2014 FoxO1 is a transcription factor regulated by insulin signaling that is deacetylated by Sirt1, a nicotinamide adenine dinucleotide- (NAD(+) -) dependent deacetylase. NAD 96-129 sirtuin 1 Mus musculus 87-92 25088223-3 2014 A new concept supports that sepsis is an immunometabolic disease and that loss of control of nuclear epigenetic regulator sirtuin 1 (SIRT-1), a NAD(+) sensor directs immune and metabolic pathways during sepsis. NAD 144-150 sirtuin 1 Mus musculus 122-131 25088223-3 2014 A new concept supports that sepsis is an immunometabolic disease and that loss of control of nuclear epigenetic regulator sirtuin 1 (SIRT-1), a NAD(+) sensor directs immune and metabolic pathways during sepsis. NAD 144-150 sirtuin 1 Mus musculus 133-139 25083875-2 2014 Specifically, the NAD(+)-dependent deacetylase SIRT1, the founding member of the sirtuin family, contributes to clock function. NAD 18-24 sirtuin 1 Mus musculus 47-52 25013930-2 2014 Here, we report a role for the NAD+-dependent histone deacetylase SIRT1 in the control of anti-bacterial defense. NAD 31-35 sirtuin 1 Mus musculus 66-71 24952428-1 2014 The silent mating type information regulation 2 homolog 1 gene (Sirt1) encodes an NAD-dependent deacetylase that modifies the activity of well-known transcriptional regulators affected in kidney diseases. NAD 82-85 sirtuin 1 Mus musculus 64-69 24687991-1 2014 The sirtuins (SIRTs; SIRT1-7) are a family of NAD(+)-dependent enzymes that dynamically regulate cellular physiology. NAD 46-52 sirtuin 1 Mus musculus 21-28 24959710-2 2014 Silent information regulator 1 (sir2 or SIRT1), a NAD-dependent deacetylase, plays complex systemic roles in a variety of processes through deacetylating acetylated histone and other specific substrates. NAD 50-53 sirtuin 1 Mus musculus 32-36 24959710-2 2014 Silent information regulator 1 (sir2 or SIRT1), a NAD-dependent deacetylase, plays complex systemic roles in a variety of processes through deacetylating acetylated histone and other specific substrates. NAD 50-53 sirtuin 1 Mus musculus 40-45 24905194-1 2014 Nicotinamide phosphoribosyltransferase (Nampt), the rate-limiting enzyme for nicotinamide adenine dinucleotide (NAD+) synthesis, and Sirt1, an NAD+-dependent histone deacetylase, protect the heart against ischemia/reperfusion (I/R). NAD 112-116 sirtuin 1 Mus musculus 133-138 24814483-0 2014 NAD(+)-dependent activation of Sirt1 corrects the phenotype in a mouse model of mitochondrial disease. NAD 0-6 sirtuin 1 Mus musculus 31-36 24814483-4 2014 As NAD(+) boosts the activity of Sirtuin1 and other sirtuins, intracellular levels of NAD(+) play a key role in the homeostatic control of mitochondrial function by the metabolic status of the cell. NAD 3-9 sirtuin 1 Mus musculus 33-41 24814483-4 2014 As NAD(+) boosts the activity of Sirtuin1 and other sirtuins, intracellular levels of NAD(+) play a key role in the homeostatic control of mitochondrial function by the metabolic status of the cell. NAD 86-92 sirtuin 1 Mus musculus 33-41 24875183-5 2014 Sirtuin family member SIRT1 was found to interact with and deacetylate FOXA2, the latter process being dependent on the NAD+-binding catalytic site of SIRT1. NAD 120-124 sirtuin 1 Mus musculus 22-27 24875183-5 2014 Sirtuin family member SIRT1 was found to interact with and deacetylate FOXA2, the latter process being dependent on the NAD+-binding catalytic site of SIRT1. NAD 120-124 sirtuin 1 Mus musculus 151-156 24936455-1 2014 The NAD-dependent deacetylase SIRT1 is involved in chromatin silencing and genome stability. NAD 4-7 sirtuin 1 Mus musculus 30-35 24480449-2 2014 Sirtuin 1 (Sirt1) is a NAD-dependent deacetylase which is involved in myogenesis. NAD 23-26 sirtuin 1 Mus musculus 0-9 24480449-2 2014 Sirtuin 1 (Sirt1) is a NAD-dependent deacetylase which is involved in myogenesis. NAD 23-26 sirtuin 1 Mus musculus 11-16 24717514-13 2014 Thus, NNMT is a novel regulator of histone methylation, polyamine flux and NAD(+)-dependent SIRT1 signalling, and is a unique and attractive target for treating obesity and type 2 diabetes. NAD 75-81 sirtuin 1 Mus musculus 92-97 24374551-1 2014 AIMS/HYPOTHESIS: Obesity is associated with ageing and increased energy intake, while restriction of energy intake improves health and longevity in multiple organisms; the NAD(+)-dependent deacetylase sirtuin 1 (SIRT1) is implicated in this process. NAD 172-178 sirtuin 1 Mus musculus 212-217 24573134-2 2014 Silent information regulator transcript-1 (SIRT1), an NAD-dependent deacetylase, mediates NF-kappaB deacetylation, and inhibits its function. NAD 54-57 sirtuin 1 Mus musculus 0-41 24573134-2 2014 Silent information regulator transcript-1 (SIRT1), an NAD-dependent deacetylase, mediates NF-kappaB deacetylation, and inhibits its function. NAD 54-57 sirtuin 1 Mus musculus 43-48 24186862-4 2014 Furthermore, we observed that flux via AR impaired NAD(+) homeostasis and reduced activity of NAD(+)-dependent deacetylase Sirt-1 leading to acetylation and prolonged expression of Egr-1 in hyperglycemic conditions. NAD 94-100 sirtuin 1 Mus musculus 123-129 24184811-2 2014 The nicotinamide adenine dinucleotide-dependent deacetylase SIRT1 regulates fatty acid metabolism through multiple nutrient sensors. NAD 4-37 sirtuin 1 Mus musculus 60-65 24410488-9 2014 propose a model linking decreased NAD+ to loss of nuclear SIRT1 activity to stabilization of the hypoxia-associated transcription factor hypoxia-inducible factor 1-alpha (HIF-1a). NAD 34-38 sirtuin 1 Mus musculus 58-63 24383546-3 2014 Compounds that activate the NAD+-dependent SIRT1 deacetylase prevent neuronal loss in an autoimmune-mediated MS model, but the mechanism of this effect is unknown, and it is unclear whether SIRT1 activating compounds exert similar effects in demyelinating disease induced by other etiologies. NAD 28-32 sirtuin 1 Mus musculus 43-48 24473773-3 2014 MacroH2A1.1 binds with high affinity O-acetyl ADP ribose, a small metabolite produced by the reaction catalysed by NAD+-dependent deacetylase SIRT1, whereas macroH2A1.2 is unable to do so. NAD 115-119 sirtuin 1 Mus musculus 142-147 24360282-5 2013 Deleting SIRT1 accelerates this process, whereas raising NAD(+) levels in old mice restores mitochondrial function to that of a young mouse in a SIRT1-dependent manner. NAD 57-63 sirtuin 1 Mus musculus 145-150 23834033-2 2013 As SIRT1 deacetylase activity is dependent on NAD(+) levels and the development of compounds that directly activate SIRT1 has been controversial, indirectly activating SIRT1 through enhancing NAD(+) bioavailability has received increasing attention. NAD 46-52 sirtuin 1 Mus musculus 3-8 23834033-5 2013 Here, we further show that miR-34a reduces NAD(+) levels and SIRT1 activity by targeting NAMPT, the rate-limiting enzyme for NAD(+) biosynthesis. NAD 125-131 sirtuin 1 Mus musculus 61-66 23990359-7 2013 PPARalpha also cooperates with Sirt1 activated by EPO through modulating the NAD+ level to regulate metabolic activity. NAD 77-81 sirtuin 1 Mus musculus 31-36 23852118-2 2013 We sought to characterize the roles of the NAD(+)-dependent deacetylase SIRT1 in the neuronal response to DNA double-strand breaks (DSBs). NAD 43-49 sirtuin 1 Mus musculus 72-77 23723308-1 2013 BACKGROUND AND PURPOSE: Sirtuin 1 (SIRT1) is a member of NAD+-dependent protein deacetylases implicated in a wide range of cellular functions and has beneficial properties in pathologies including ischemia/reperfusion processes and neurodegeneration. NAD 57-60 sirtuin 1 Mus musculus 24-33 23723308-1 2013 BACKGROUND AND PURPOSE: Sirtuin 1 (SIRT1) is a member of NAD+-dependent protein deacetylases implicated in a wide range of cellular functions and has beneficial properties in pathologies including ischemia/reperfusion processes and neurodegeneration. NAD 57-60 sirtuin 1 Mus musculus 35-40 23876775-5 2013 Recent studies have shown that sirtuin 1 (Sirt1), a nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylase, is a critical negative regulator of both the innate and adaptive immune response in mice, and its altered functions are likely to be involved in autoimmune diseases. NAD 52-85 sirtuin 1 Mus musculus 31-40 23876775-5 2013 Recent studies have shown that sirtuin 1 (Sirt1), a nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylase, is a critical negative regulator of both the innate and adaptive immune response in mice, and its altered functions are likely to be involved in autoimmune diseases. NAD 52-85 sirtuin 1 Mus musculus 42-47 23604553-1 2013 AIMS/HYPOTHESIS: The NAD(+)-dependent protein deacetylase sirtuin (SIRT)1 is thought to be a key regulator of skeletal muscle metabolism. NAD 21-27 sirtuin 1 Mus musculus 67-73 23673559-1 2013 Sirtuin 5 (SIRT5) is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, belonging to the silent information regulator 2 (Sir2) family of sirtuin histone deacetylases (sirtuins). NAD 23-56 sirtuin 1 Mus musculus 104-134 23673559-1 2013 Sirtuin 5 (SIRT5) is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, belonging to the silent information regulator 2 (Sir2) family of sirtuin histone deacetylases (sirtuins). NAD 23-56 sirtuin 1 Mus musculus 136-140 23673559-1 2013 Sirtuin 5 (SIRT5) is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, belonging to the silent information regulator 2 (Sir2) family of sirtuin histone deacetylases (sirtuins). NAD 58-61 sirtuin 1 Mus musculus 104-134 23673559-1 2013 Sirtuin 5 (SIRT5) is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, belonging to the silent information regulator 2 (Sir2) family of sirtuin histone deacetylases (sirtuins). NAD 58-61 sirtuin 1 Mus musculus 136-140 23778143-2 2013 Here, we used Pkd1 mutant mouse models to demonstrate that the nicotinamide adenine dinucleotide-dependent (NAD-dependent) protein deacetylase sirtuin 1 (SIRT1) is involved in the pathophysiology of ADPKD. NAD 63-96 sirtuin 1 Mus musculus 143-152 23778143-2 2013 Here, we used Pkd1 mutant mouse models to demonstrate that the nicotinamide adenine dinucleotide-dependent (NAD-dependent) protein deacetylase sirtuin 1 (SIRT1) is involved in the pathophysiology of ADPKD. NAD 63-96 sirtuin 1 Mus musculus 154-159 23778143-2 2013 Here, we used Pkd1 mutant mouse models to demonstrate that the nicotinamide adenine dinucleotide-dependent (NAD-dependent) protein deacetylase sirtuin 1 (SIRT1) is involved in the pathophysiology of ADPKD. NAD 108-111 sirtuin 1 Mus musculus 143-152 23778143-2 2013 Here, we used Pkd1 mutant mouse models to demonstrate that the nicotinamide adenine dinucleotide-dependent (NAD-dependent) protein deacetylase sirtuin 1 (SIRT1) is involved in the pathophysiology of ADPKD. NAD 108-111 sirtuin 1 Mus musculus 154-159 23547115-2 2013 This suggested that activators of SIRT1, a highly conserved NAD-dependent protein deacetylase, might have immune-modulating or neuroprotective therapeutic effects in EAE. NAD 60-63 sirtuin 1 Mus musculus 34-39 23547115-7 2013 Significant neuroprotective effects were observed, with fewer apoptotic cells found in the spinal cords of SIRT1-overexpressing EAE mice associated with increased brain-derived neurotrophic factor and NAD levels. NAD 201-204 sirtuin 1 Mus musculus 107-112 23404532-3 2013 Here we examine the role of an NAD(+) -dependent histone deacetylase, SIRT1, in modulating the neurogenic potential of neural precursors in the neurogenic niches of the adult mouse brain. NAD 31-37 sirtuin 1 Mus musculus 70-75 23457303-1 2013 Sirt1 is a NAD(+)-dependent class III deacetylase that functions as a cellular energy sensor. NAD 11-17 sirtuin 1 Mus musculus 0-5 23439428-1 2013 Human sirtuin1 (SIRT1), the closest homolog of the yeast sir2 protein, functions as an NAD+-dependent histone and non-histone protein deacetylase in several cellular processes, like energy metabolism, stress responses, aging, etc. NAD 87-91 sirtuin 1 Mus musculus 16-21 24020004-1 2013 SIRT1 is a NAD(+)-dependent protein deacetylase that has a very large number of established protein substrates and an equally impressive list of biological functions thought to be regulated by its activity. NAD 11-15 sirtuin 1 Mus musculus 0-5 23302720-4 2013 Here, younger mice were found to express higher levels of the NAD(+)-dependent histone deacetylase SIRT1 in the kidney. NAD 62-68 sirtuin 1 Mus musculus 99-104 23297412-2 2013 Here, we show that oral administration of resveratrol, which leads to activation of an NAD(+)-dependent protein deacetylase SIRT1, suppresses cardiac hypertrophy and fibrosis and restores cardiac diastolic function in dystrophin-deficient mdx mice. NAD 87-93 sirtuin 1 Mus musculus 124-129 23146569-2 2013 Resveratrol has been reported to be an activator of NAD+-dependent deacetylase sirtuin 1 (SIRT1), which may regulate liver X receptor (LXR) activity, thereby upregulating the expression of genes crucial in reverse cholesterol transport (RCT). NAD 52-55 sirtuin 1 Mus musculus 90-95 23042952-2 2013 RSV targets and activates the NAD(+)-dependent protein deacetylase SIRT1; in turn, SIRT1 induces an intracellular antioxidative mechanism by inducing mitochondrial superoxide dismutase (SOD2). NAD 30-36 sirtuin 1 Mus musculus 67-72 23042952-2 2013 RSV targets and activates the NAD(+)-dependent protein deacetylase SIRT1; in turn, SIRT1 induces an intracellular antioxidative mechanism by inducing mitochondrial superoxide dismutase (SOD2). NAD 30-36 sirtuin 1 Mus musculus 83-88 23096014-4 2012 We previously showed these mechanisms are also involved in Zn(2+) neurotoxicity and are attenuated by nicotinamide- or pyruvate-induced restoration of NAD(+) concentrations, Zn(2+) restriction, or inhibition of Sir2 proteins. NAD 151-157 sirtuin 1 Mus musculus 211-215 23160044-6 2012 BCL6 triggered exclusion of the co-activator Mastermind-like 1 and recruitment of the NAD(+)-dependent deacetylase Sirt1, which was required for BCL6-dependent neurogenesis. NAD 86-92 sirtuin 1 Mus musculus 115-120 23137106-2 2012 Telmisartan has been reported to function as a partial agonist of the peroxisome proliferator-activated receptor (PPAR) gamma, which is also targeted by the nicotinamide adenine dinucleotide (NAD)-dependent deacetylase (SIRT1). NAD 157-190 sirtuin 1 Mus musculus 220-225 23137106-2 2012 Telmisartan has been reported to function as a partial agonist of the peroxisome proliferator-activated receptor (PPAR) gamma, which is also targeted by the nicotinamide adenine dinucleotide (NAD)-dependent deacetylase (SIRT1). NAD 192-195 sirtuin 1 Mus musculus 220-225 23137106-7 2012 Moreover, in vitro treatment with telmisartan led to increased expression of Sirt1 mRNA in C2C12 skeletal muscle cells; the increase in Sirt1 mRNA in telmisartan-treated C2C12 myoblasts occurred concomitantly with an increase in AMPK phosphorylation, an increase in NAD+/NADH ratio, and increases in the mRNA levels of PGC1alpha, FATP1, ACO, and GLUT4. NAD 266-270 sirtuin 1 Mus musculus 136-141 23137106-7 2012 Moreover, in vitro treatment with telmisartan led to increased expression of Sirt1 mRNA in C2C12 skeletal muscle cells; the increase in Sirt1 mRNA in telmisartan-treated C2C12 myoblasts occurred concomitantly with an increase in AMPK phosphorylation, an increase in NAD+/NADH ratio, and increases in the mRNA levels of PGC1alpha, FATP1, ACO, and GLUT4. NAD 271-275 sirtuin 1 Mus musculus 136-141 22691943-1 2012 Locally acting insulin growth factor isoform (mIGF-1) and the NAD+-dependent protein deacetylase SIRT1 are implicated in life and health span. NAD 62-65 sirtuin 1 Mus musculus 97-102 22456698-6 2012 RESULTS: ALA increased the NAD(+)/NADH ratio to enhance SIRT1 activity and production in C(2)C(12) myotubes. NAD 27-33 sirtuin 1 Mus musculus 56-61 22456698-6 2012 RESULTS: ALA increased the NAD(+)/NADH ratio to enhance SIRT1 activity and production in C(2)C(12) myotubes. NAD 34-38 sirtuin 1 Mus musculus 56-61 23565341-7 2012 RESULTS: 1) sirtuin pathway inhibition or SIRT1 knockdown attenuated Zn2+-, STZ-, and cytokine-mediated toxicity and NAD+ loss in beta-cells, 2) SIRT1 overexpression potentiated these toxicities, 3) young SIRT1 beta-cell transgenic mice have improved glucose tolerance under basal conditions, but upon aging showed increased sensitivity to streptozotocin compared to SIRT1 +/- mice, and 4) SIRT1 +/- mice in an NOD background or exposed to streptozotocin trended toward reduced diabetic incidence and mortality compared to wildtype. NAD 117-121 sirtuin 1 Mus musculus 42-47 23565341-8 2012 CONCLUSIONS: These results have implicated SIRT1-mediated NAD+ loss in Zn2+, STZ, or cytokine toxicities of MIN6, and in NOD or streptozotocin T1DM animal models. NAD 58-62 sirtuin 1 Mus musculus 43-48 22542455-1 2012 The NAD-dependent histone deacetylase Sirt1 antagonizes p53 transcriptional activity to regulate cell-cycle progression and apoptosis. NAD 4-7 sirtuin 1 Mus musculus 38-43 22654783-1 2012 Resveratrol is a naturally occurring polyphenol that activates SIRT1, an NAD-dependent deacetylase. NAD 73-76 sirtuin 1 Mus musculus 63-68 22312127-6 2012 Acetylation and stability of wild-type, but not mutant, Foxp3 is enhanced when cells are treated with Ex-527, an inhibitor of the NAD(+)-dependent deacetylase SIRT1. NAD 130-136 sirtuin 1 Mus musculus 159-164 22306819-0 2012 NAD-dependent histone deacetylase, SIRT1, plays essential roles in the maintenance of hematopoietic stem cells. NAD 0-3 sirtuin 1 Mus musculus 35-40 22316301-2 2012 NAD-dependent deacetylase sirtuin-1(SIRT1) is an important hub which links lipid metabolism with circadian clock by its deacetylation activity depends on intracellular NAD+/NADH content ratio. NAD 0-3 sirtuin 1 Mus musculus 36-41 22316301-2 2012 NAD-dependent deacetylase sirtuin-1(SIRT1) is an important hub which links lipid metabolism with circadian clock by its deacetylation activity depends on intracellular NAD+/NADH content ratio. NAD 168-172 sirtuin 1 Mus musculus 36-41 22316301-2 2012 NAD-dependent deacetylase sirtuin-1(SIRT1) is an important hub which links lipid metabolism with circadian clock by its deacetylation activity depends on intracellular NAD+/NADH content ratio. NAD 173-177 sirtuin 1 Mus musculus 36-41 22006156-1 2012 The protein encoded by the sirt1 gene is an enzyme, SirT1, that couples the hydrolysis of NAD(+) to the deacetylation of acetyl-lysine residues in substrate proteins. NAD 90-96 sirtuin 1 Mus musculus 27-32 22006156-1 2012 The protein encoded by the sirt1 gene is an enzyme, SirT1, that couples the hydrolysis of NAD(+) to the deacetylation of acetyl-lysine residues in substrate proteins. NAD 90-96 sirtuin 1 Mus musculus 52-57 22105513-1 2012 The NAD-dependent histone deacetylase sirtuin (Sirt)1 is implicated in a wide variety of physiological processes, ranging from tumorigenesis to mitochondrial biogenesis to neuronal development. NAD 4-7 sirtuin 1 Mus musculus 47-53 22195961-1 2011 The NAD(+)-dependent deacetylase SIRT1 is an evolutionarily conserved metabolic sensor of the Sirtuin family that mediates homeostatic responses to certain physiological stresses such as nutrient restriction. NAD 4-10 sirtuin 1 Mus musculus 33-38 22195961-2 2011 Previous reports have implicated fluctuations in intracellular NAD(+) concentrations as the principal regulator of SIRT1 activity. NAD 63-69 sirtuin 1 Mus musculus 115-120 22195961-3 2011 However, here we have identified a cAMP-induced phosphorylation of a highly conserved serine (S434) located in the SIRT1 catalytic domain that rapidly enhanced intrinsic deacetylase activity independently of changes in NAD(+) levels. NAD 219-225 sirtuin 1 Mus musculus 115-120 21901281-4 2011 One of its potential targets is the NAD(+)-dependent deacetylase sirtuin 1. NAD 36-42 sirtuin 1 Mus musculus 65-74 21998399-13 2011 CONCLUSIONS: Our results demonstrate that Wld(S) combines an insulinotropic effect with protection against beta-cell failure and suggest that enhancing NAD biosynthesis in beta-cells to increase SIRT1 activity could be a potential therapeutic approach for diabetes. NAD 152-155 sirtuin 1 Mus musculus 195-200 22013015-6 2011 SirT1 activity was evaluated using an in vitro deacetylation assay and correlated with the NAD(+)-to-NADH ratio. NAD 91-97 sirtuin 1 Mus musculus 0-5 22013015-6 2011 SirT1 activity was evaluated using an in vitro deacetylation assay and correlated with the NAD(+)-to-NADH ratio. NAD 101-105 sirtuin 1 Mus musculus 0-5 21652783-2 2011 We previously showed that resveratrol (3,5,4"-trihydroxy-trans-stilbene), an antioxidant and activator of the NAD(+)-dependent protein deacetylase SIRT1, delays the progression of heart failure and prolongs the lifespan of delta-sarcoglycan-deficient hamsters. NAD 110-116 sirtuin 1 Mus musculus 147-152 21593185-3 2011 The nicotinamide adenine dinucleotide-dependent protein deacetylase SIRT1 decreases apoptosis through deacetylating of p53, and resveratrol is known as an activator of SIRT1. NAD 4-37 sirtuin 1 Mus musculus 68-73 21715639-7 2011 The underlying mechanisms for this shift in differentiation direction involve the astrogenesis promoting Sirt1 via an increased NAD/NADH ratio in ogg1(-/-) cells. NAD 128-131 sirtuin 1 Mus musculus 105-110 21715639-7 2011 The underlying mechanisms for this shift in differentiation direction involve the astrogenesis promoting Sirt1 via an increased NAD/NADH ratio in ogg1(-/-) cells. NAD 132-136 sirtuin 1 Mus musculus 105-110 21499261-3 2011 Here we report that the NAD(+)-dependent deacetylase SIRT1 acts as an intrinsic negative modulator of Notch signalling in endothelial cells. NAD 24-30 sirtuin 1 Mus musculus 53-58 21459317-3 2011 This metabolic phenotype is achieved, in part, through SIRT1 activation, either by increasing NAD(+) levels or by promoting SIRT1 expression. NAD 94-100 sirtuin 1 Mus musculus 55-60 21459329-1 2011 SIRT1 is a NAD(+)-dependent enzyme that affects metabolism by deacetylating key transcriptional regulators of energy expenditure. NAD 11-17 sirtuin 1 Mus musculus 0-5 21459330-2 2011 The fact that NAD(+) levels control SIRT1 activity confers a hypothetical basis for the design of new strategies to activate SIRT1 by increasing NAD(+) availability. NAD 14-20 sirtuin 1 Mus musculus 36-41 21459330-2 2011 The fact that NAD(+) levels control SIRT1 activity confers a hypothetical basis for the design of new strategies to activate SIRT1 by increasing NAD(+) availability. NAD 14-20 sirtuin 1 Mus musculus 125-130 21459330-2 2011 The fact that NAD(+) levels control SIRT1 activity confers a hypothetical basis for the design of new strategies to activate SIRT1 by increasing NAD(+) availability. NAD 145-151 sirtuin 1 Mus musculus 36-41 21459330-2 2011 The fact that NAD(+) levels control SIRT1 activity confers a hypothetical basis for the design of new strategies to activate SIRT1 by increasing NAD(+) availability. NAD 145-151 sirtuin 1 Mus musculus 125-130 21411645-3 2011 SIRT1 is an nicotinamide adenine dinucleotide responsive deacetylase serving diverse adaptive responses to metabolic challenges, yet this metabolic rheostat may be downregulated under conditions of significant oxidative stress. NAD 12-45 sirtuin 1 Mus musculus 0-5 21165558-1 2011 Sirtuin 3 (SIRT3) is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, which belongs to the Silent information regulator 2 (Sir2) family of histone deacetylases (sirtuin HDACs). NAD 23-56 sirtuin 1 Mus musculus 108-138 21165558-1 2011 Sirtuin 3 (SIRT3) is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, which belongs to the Silent information regulator 2 (Sir2) family of histone deacetylases (sirtuin HDACs). NAD 23-56 sirtuin 1 Mus musculus 140-144 21349442-11 2011 : The specific inhibition of Abeta generation by SIRT1 coupled with the potential link between aerobic glycolysis, NAD(+) depletion, and amyloidogenesis through the sirtuin pathway has translational implications. NAD 115-121 sirtuin 1 Mus musculus 49-54 20823277-11 2011 Inhibition of nicotinamide phosphoribosyltransferase (Nampt, an important enzyme which regulates SIRT1 activity by maintaining availability of the substrate NAD(+)) also blocked both IPC-induced deacetylation and cardioprotection. NAD 157-164 sirtuin 1 Mus musculus 97-102 20823277-13 2011 Inhibition of SIRT1, either directly or by restricting the availability of its substrate NAD(+), inhibits IPC. NAD 89-95 sirtuin 1 Mus musculus 14-19 21246601-9 2011 In neurons, Nampt positively modulated NAD(+) levels and thereby controlled SIRT1 activity. NAD 39-45 sirtuin 1 Mus musculus 76-81 21750730-9 2011 In addition, we showed that SIRT1 was required for both exogenous NAD and Wld(S)-mediated cellular protection against paraquat. NAD 66-69 sirtuin 1 Mus musculus 28-33 21030595-4 2010 DBC1 has been previously identified as a regulator of some nuclear receptors, the methyltransferase SUV39H1, and the NAD-dependent deacetylase SIRT1. NAD 117-120 sirtuin 1 Mus musculus 143-148 21103071-1 2010 SIRT1, a homolog of yeast Sir2, is a type III NAD(+) dependent histone and protein deacetylase. NAD 46-52 sirtuin 1 Mus musculus 0-5 20074616-1 2010 Sirt1 is a NAD-dependent deacetylase that has been shown as a link between energy metabolism and aging. NAD 11-14 sirtuin 1 Mus musculus 0-5 20655472-3 2010 Here we show that production of beta-amyloid and plaques in a mouse model of AD are reduced by overexpressing the NAD-dependent deacetylase SIRT1 in brain, and are increased by knocking out SIRT1 in brain. NAD 114-117 sirtuin 1 Mus musculus 140-145 20668706-1 2010 BACKGROUND: SIRT1, a NAD-dependent deacetylase, has diverse roles in a variety of organs such as regulation of endocrine function and metabolism. NAD 21-24 sirtuin 1 Mus musculus 12-17 20616029-6 2010 FGF21 treatment increased cellular NAD(+) levels, leading to activation of SIRT1 and deacetylation of its downstream targets, peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) and histone 3. NAD 35-41 sirtuin 1 Mus musculus 75-80 20620997-3 2010 Here we show that lack of nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase SIRT1 in pro-opiomelanocortin (POMC) neurons causes hypersensitivity to diet-induced obesity due to reduced energy expenditure. NAD 26-59 sirtuin 1 Mus musculus 91-96 20620997-3 2010 Here we show that lack of nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase SIRT1 in pro-opiomelanocortin (POMC) neurons causes hypersensitivity to diet-induced obesity due to reduced energy expenditure. NAD 61-68 sirtuin 1 Mus musculus 91-96 20634564-2 2010 SIRT1 expression is regulated transcriptionally and post-transcriptionally, and its enzymatic activity is controlled by NAD+ levels and interacting proteins. NAD 120-124 sirtuin 1 Mus musculus 0-5 20595232-5 2010 We demonstrate here a conserved role for orthologs of the NAD(+)-dependent deacetylase SIRT1 in metazoans in down-regulation of SREBP orthologs during fasting, resulting in inhibition of lipid synthesis and fat storage. NAD 58-64 sirtuin 1 Mus musculus 87-92 20620956-5 2010 During hypoxia, SIRT1 was downregulated due to decreased NAD(+) levels, which allowed the acetylation and activation of HIF-1alpha. NAD 57-63 sirtuin 1 Mus musculus 16-21 20148352-2 2010 CR induces an increase in the NAD(+)/NADH ratio in cells and results in activation of SIRT1, an NAD(+)-dependent protein deacetylase that is thought to be a metabolic master switch linked to the modulation of lifespans. NAD 30-36 sirtuin 1 Mus musculus 86-91 20148352-2 2010 CR induces an increase in the NAD(+)/NADH ratio in cells and results in activation of SIRT1, an NAD(+)-dependent protein deacetylase that is thought to be a metabolic master switch linked to the modulation of lifespans. NAD 37-41 sirtuin 1 Mus musculus 86-91 20148352-10 2010 A 24-h fasting in mice increased mRNA and protein expression of both SIRT1 and PPARalpha in the livers, where the NAD(+) levels increased with increasing nicotinamide phosphoribosyltransferase (NAMPT) activity in the NAD(+) salvage pathway. NAD 114-120 sirtuin 1 Mus musculus 69-74 20148352-10 2010 A 24-h fasting in mice increased mRNA and protein expression of both SIRT1 and PPARalpha in the livers, where the NAD(+) levels increased with increasing nicotinamide phosphoribosyltransferase (NAMPT) activity in the NAD(+) salvage pathway. NAD 217-223 sirtuin 1 Mus musculus 69-74 20148352-11 2010 Treatment of Hepa1-6 cells in a low glucose medium conditions with NAD(+) or NADH showed that the mRNA expression of both SIRT1 and PPARalpha can be enhanced by addition of NAD(+), and decreased by increasing NADH levels. NAD 67-73 sirtuin 1 Mus musculus 122-127 20148352-11 2010 Treatment of Hepa1-6 cells in a low glucose medium conditions with NAD(+) or NADH showed that the mRNA expression of both SIRT1 and PPARalpha can be enhanced by addition of NAD(+), and decreased by increasing NADH levels. NAD 77-81 sirtuin 1 Mus musculus 122-127 20148352-11 2010 Treatment of Hepa1-6 cells in a low glucose medium conditions with NAD(+) or NADH showed that the mRNA expression of both SIRT1 and PPARalpha can be enhanced by addition of NAD(+), and decreased by increasing NADH levels. NAD 173-179 sirtuin 1 Mus musculus 122-127 20148352-11 2010 Treatment of Hepa1-6 cells in a low glucose medium conditions with NAD(+) or NADH showed that the mRNA expression of both SIRT1 and PPARalpha can be enhanced by addition of NAD(+), and decreased by increasing NADH levels. NAD 209-213 sirtuin 1 Mus musculus 122-127 20354108-1 2010 Sirtuin 1 (SirT1) is the largest of the seven members of the sirtuin family of class III nicotinamide adenine dinucleotide (NAD(+))-dependent protein deacetylases, whose activation is beneficial for metabolic, neurodegenerative, inflammatory and neoplastic diseases, and augments life span in model organisms (Finkel et al., 2009; Lavu et al., 2008). NAD 89-122 sirtuin 1 Mus musculus 0-9 20354108-1 2010 Sirtuin 1 (SirT1) is the largest of the seven members of the sirtuin family of class III nicotinamide adenine dinucleotide (NAD(+))-dependent protein deacetylases, whose activation is beneficial for metabolic, neurodegenerative, inflammatory and neoplastic diseases, and augments life span in model organisms (Finkel et al., 2009; Lavu et al., 2008). NAD 89-122 sirtuin 1 Mus musculus 11-16 20354108-1 2010 Sirtuin 1 (SirT1) is the largest of the seven members of the sirtuin family of class III nicotinamide adenine dinucleotide (NAD(+))-dependent protein deacetylases, whose activation is beneficial for metabolic, neurodegenerative, inflammatory and neoplastic diseases, and augments life span in model organisms (Finkel et al., 2009; Lavu et al., 2008). NAD 124-129 sirtuin 1 Mus musculus 0-9 20354108-1 2010 Sirtuin 1 (SirT1) is the largest of the seven members of the sirtuin family of class III nicotinamide adenine dinucleotide (NAD(+))-dependent protein deacetylases, whose activation is beneficial for metabolic, neurodegenerative, inflammatory and neoplastic diseases, and augments life span in model organisms (Finkel et al., 2009; Lavu et al., 2008). NAD 124-129 sirtuin 1 Mus musculus 11-16 20139070-1 2010 Sirt1, a NAD-dependent protein deacetylase, is reported to regulate intracellular metabolism and attenuate reactive oxidative species (ROS)-induced apoptosis leading to longevity and acute stress resistance. NAD 9-12 sirtuin 1 Mus musculus 0-5 20185821-1 2010 Sirtuin 1 (SIRT1) is a NAD-dependent deacetylase that is critically involved in diverse cellular processes including metabolic disease, cancer, and possibly aging. NAD 23-26 sirtuin 1 Mus musculus 0-9 20185821-1 2010 Sirtuin 1 (SIRT1) is a NAD-dependent deacetylase that is critically involved in diverse cellular processes including metabolic disease, cancer, and possibly aging. NAD 23-26 sirtuin 1 Mus musculus 11-16 20335657-3 2010 Here, we investigated in mice the mechanisms underlying CR-mediated protection against hypoxia in aged kidney, with a special focus on the role of the NAD-dependent deacetylase sirtuin 1 (Sirt1), which is linked to CR-related longevity in model organisms, on mitochondrial autophagy. NAD 151-154 sirtuin 1 Mus musculus 188-193 20093281-7 2010 SIRT1 was increased through an AMP-activated protein kinase-mediated increase in gene expression of nicotinamide phosphoribosyltransferase, the rate-limiting enzyme of the salvage pathway for NAD(+). NAD 192-198 sirtuin 1 Mus musculus 0-5 19934007-10 2010 In addition, resveratrol increased the NAD-to-NADH ratio in an AMPK-dependent manner, which may explain how resveratrol may activate Sirt1 indirectly. NAD 39-42 sirtuin 1 Mus musculus 133-138 19934007-10 2010 In addition, resveratrol increased the NAD-to-NADH ratio in an AMPK-dependent manner, which may explain how resveratrol may activate Sirt1 indirectly. NAD 46-50 sirtuin 1 Mus musculus 133-138 20097174-1 2010 SIR2 protein, an NAD-dependent deacetylase, is localized to nucleus and is involved in life span extension by calorie restriction in yeast. NAD 17-20 sirtuin 1 Mus musculus 0-4 20060806-1 2010 Sirtuin1 (SIRT1) deacetylase and poly(ADP-ribose)-polymerase-1 (PARP-1) respond to environmental cues, and both require NAD(+) cofactor for their enzymatic activities. NAD 120-126 sirtuin 1 Mus musculus 0-8 20060806-1 2010 Sirtuin1 (SIRT1) deacetylase and poly(ADP-ribose)-polymerase-1 (PARP-1) respond to environmental cues, and both require NAD(+) cofactor for their enzymatic activities. NAD 120-126 sirtuin 1 Mus musculus 10-15 20060806-2 2010 However, the functional link between environmental/oxidative stress-mediated activation of PARP-1 and SIRT1 through NAD(+) cofactor availability is not known. NAD 116-122 sirtuin 1 Mus musculus 102-107 20060806-3 2010 We investigated whether NAD(+) depletion by PARP-1 activation plays a role in environmental stimuli/oxidant-induced reduction in SIRT1 activity. NAD 24-30 sirtuin 1 Mus musculus 129-134 19940131-5 2010 By using gene knock-out and transgenic mouse models of SIRT3 and SIRT1, we showed that the anti-hypertrophic effects of exogenous NAD are mediated through activation of SIRT3, but not SIRT1. NAD 130-133 sirtuin 1 Mus musculus 65-70 20228935-4 2009 In the murine heart, moderate overexpression of the NAD(+)-dependent deacetylase SirT1 was reported to mitigate oxidative stress. NAD 52-58 sirtuin 1 Mus musculus 81-86 19672559-1 2009 Poly(ADP-ribose) polymerase-1 (Parp-1) and the protein deacetylase SirT1 are two of the most effective NAD(+)-consuming enzymes in the cell with key functions in genome integrity and chromatin-based pathways. NAD 103-109 sirtuin 1 Mus musculus 67-72 19661458-1 2009 RATIONALE: NAD+ acts not only as a cofactor for cellular respiration but also as a substrate for NAD(+)-dependent enzymes, such as Sirt1. NAD 11-15 sirtuin 1 Mus musculus 131-136 19661458-1 2009 RATIONALE: NAD+ acts not only as a cofactor for cellular respiration but also as a substrate for NAD(+)-dependent enzymes, such as Sirt1. NAD 97-103 sirtuin 1 Mus musculus 131-136 19680552-1 2009 SIRT1, an NAD(+) (nicotinamide adenine dinucleotide)-dependent deacetylase, protects cells from stress-induced apoptosis, and its orthologues delay aging in lower eukaryotes. NAD 10-16 sirtuin 1 Mus musculus 0-5 18932012-5 2009 The products NAD(+) and NADPH are required in many critical biological processes, e.g., NAD(+) is used by histone deacetylase Sir2 which regulates longevity in different species. NAD 13-19 sirtuin 1 Mus musculus 126-130 18932012-5 2009 The products NAD(+) and NADPH are required in many critical biological processes, e.g., NAD(+) is used by histone deacetylase Sir2 which regulates longevity in different species. NAD 88-94 sirtuin 1 Mus musculus 126-130 19470756-1 2009 Poly(ADP-ribose) polymerase 1 (PARP1) and SIRT1 deacetylase are two NAD-dependent enzymes which play major roles in the decision of a cell to live or to die in a stress situation. NAD 68-71 sirtuin 1 Mus musculus 42-47 19491102-5 2009 Here we demonstrate that the NAD(+)-dependent deacetylase sirtuin 1 (Sirt1) functionally and physically interacts with Dot1 to enhance the distributive activity of Dot1 on H3K79 methylation and thereby represses alpha-ENaC transcription in mIMCD3 cells. NAD 29-35 sirtuin 1 Mus musculus 58-67 19491102-5 2009 Here we demonstrate that the NAD(+)-dependent deacetylase sirtuin 1 (Sirt1) functionally and physically interacts with Dot1 to enhance the distributive activity of Dot1 on H3K79 methylation and thereby represses alpha-ENaC transcription in mIMCD3 cells. NAD 29-35 sirtuin 1 Mus musculus 69-74 19306844-1 2009 The sirtuins (SIRT1-7), also being referred to as class III HDACs, exert NAD-dependent deacetylase and/or ADP-ribosyltransferase activities in various cellular compartments including the cell nucleus, the cytoplasm and the mitochondria. NAD 73-76 sirtuin 1 Mus musculus 14-19 19286518-0 2009 Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1. NAD 25-29 sirtuin 1 Mus musculus 55-60 19286518-2 2009 We have shown that the core circadian regulator, CLOCK, is a histone acetyltransferase whose activity is counterbalanced by the nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylase SIRT1. NAD 128-161 sirtuin 1 Mus musculus 199-204 19286518-2 2009 We have shown that the core circadian regulator, CLOCK, is a histone acetyltransferase whose activity is counterbalanced by the nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylase SIRT1. NAD 163-167 sirtuin 1 Mus musculus 199-204 19262508-5 2009 Here we demonstrate that AMPK controls the expression of genes involved in energy metabolism in mouse skeletal muscle by acting in coordination with another metabolic sensor, the NAD+-dependent type III deacetylase SIRT1. NAD 179-183 sirtuin 1 Mus musculus 215-220 19262508-6 2009 AMPK enhances SIRT1 activity by increasing cellular NAD+ levels, resulting in the deacetylation and modulation of the activity of downstream SIRT1 targets that include the peroxisome proliferator-activated receptor-gamma coactivator 1alpha and the forkhead box O1 (FOXO1) and O3 (FOXO3a) transcription factors. NAD 52-56 sirtuin 1 Mus musculus 14-19 19199480-1 2009 A series of imidazo[1,2-b]thiazole derivatives is shown to activate the NAD(+)-dependent deacetylase SIRT1, a potential new therapeutic target to treat various metabolic disorders. NAD 72-78 sirtuin 1 Mus musculus 101-106 19284563-3 2009 The NAD+-dependent protein deacetylase SIRT1 has been implicated as one of the key downstream regulators of CR in yeast, rodents, and humans. NAD 4-7 sirtuin 1 Mus musculus 39-44 19148549-0 2009 Chromosomal characterization and localization of the NAD+-dependent histone deacetylase gene sirtuin 1 in the mouse. NAD 53-57 sirtuin 1 Mus musculus 93-102 19288225-0 2009 Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons. NAD 104-108 sirtuin 1 Mus musculus 124-129 19288225-2 2009 Here we studied the roles of NAD(+) bioenergetic state, and the NAD(+)-dependent enzymes SIRT1 and PARP-1, in excitotoxic neuronal death in cultured neurons and in a mouse model of focal ischemic stroke. NAD 64-70 sirtuin 1 Mus musculus 89-94 19288225-12 2009 Our data further suggest that, SIRT1 is linked to bioenergetic state and stress responses in neurons, and that under conditions of reduced cellular energy levels SIRT1 enzyme activity may consume sufficient NAD(+) to nullify any cell survival-promoting effects of its deacetylase action on protein substrates. NAD 207-213 sirtuin 1 Mus musculus 162-167 19046567-1 2008 The NAD(+)-dependent deacetylase SIRT1 controls metabolic processes in response to low nutrient availability. NAD 4-10 sirtuin 1 Mus musculus 33-38 18752667-5 2008 Given that increased levels of nicotinamide adenine dinucleotide (NAD) via deletion of CD38 have been shown to prevent high fat diet induced obesity in mice in a SIRT-1 dependent fashion we explored the possibility of directly applying NAD to zebrafish. NAD 66-69 sirtuin 1 Mus musculus 162-168 18662547-0 2008 The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. NAD 4-8 sirtuin 1 Mus musculus 31-36 18662547-4 2008 We show that the HDAC activity of the NAD(+)-dependent SIRT1 enzyme is regulated in a circadian manner, correlating with rhythmic acetylation of BMAL1 and H3 Lys9/Lys14 at circadian promoters. NAD 38-44 sirtuin 1 Mus musculus 55-60 18296641-0 2008 A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. NAD 15-18 sirtuin 1 Mus musculus 41-46 18296641-1 2008 We demonstrate a role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. NAD 30-33 sirtuin 1 Mus musculus 56-61 18296641-6 2008 In vitro, Sirt1 can, in an NAD-dependent fashion, directly deacetylate these components. NAD 27-30 sirtuin 1 Mus musculus 10-15 18005249-8 2008 These findings provide insight into the age-dependent regulation of Sirt1 activity and suggest that enhancement of systemic NAD biosynthesis and Sirt1 activity in tissues such as beta cells may be an effective therapeutic intervention for age-associated metabolic disorders such as type 2 diabetes. NAD 124-127 sirtuin 1 Mus musculus 68-73 18046409-2 2007 SIRT1, an NAD+-dependent deacetylase, is a principal modulator of pathways downstream of calorie restriction that produce beneficial effects on glucose homeostasis and insulin sensitivity. NAD 10-13 sirtuin 1 Mus musculus 0-5 17482543-1 2007 Although NAD(+) biosynthesis is required for Sir2 functions and replicative lifespan in yeast, alterations in NAD(+) precursors have been reported to accelerate aging but not to extend lifespan. NAD 9-15 sirtuin 1 Mus musculus 45-49 17197703-0 2007 Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1. NAD 35-39 sirtuin 1 Mus musculus 70-75 17174885-1 2006 Resveratrol increases life span in lower organisms by activating the NAD(+)-dependent histone deacetylase Sirt1. NAD 69-75 sirtuin 1 Mus musculus 106-111 17380200-8 2006 Finally, crosstalk between CD38 and other NAD(+) utilizing enzymes such as ART2, SIRT1, and PARP-1 impacts NAD(+) homeostasis, inflammation, and immunity. NAD 42-48 sirtuin 1 Mus musculus 81-86 17380200-8 2006 Finally, crosstalk between CD38 and other NAD(+) utilizing enzymes such as ART2, SIRT1, and PARP-1 impacts NAD(+) homeostasis, inflammation, and immunity. NAD 107-113 sirtuin 1 Mus musculus 81-86 16935261-0 2006 Regulation of SIRT 1 mediated NAD dependent deacetylation: a novel role for the multifunctional enzyme CD38. NAD 30-33 sirtuin 1 Mus musculus 14-20 16935261-7 2006 We propose that by modulating availability of NAD to the SIRT1 enzyme, CD38 may regulate SIRT1 enzymatic activity. NAD 46-49 sirtuin 1 Mus musculus 57-62 16935261-7 2006 We propose that by modulating availability of NAD to the SIRT1 enzyme, CD38 may regulate SIRT1 enzymatic activity. NAD 46-49 sirtuin 1 Mus musculus 89-94 16632544-9 2006 This type of cell death was blocked by repletion of cellular NAD levels as well as by activation of the longevity factor Sir2alpha deacetylase, indicating that PARP induction and subsequent depletion of NAD levels are the sequence of events causing angiotensin II-mediated cardiomyocyte cell death. NAD 203-206 sirtuin 1 Mus musculus 121-130 16959573-1 2006 Sir2 is an NAD-dependent deacetylase that connects metabolism with longevity in yeast, flies, and worms. NAD 11-14 sirtuin 1 Mus musculus 0-4 16917544-6 2006 Importantly, mutagenesis of the LXXLL motif eliminated FoxO1 interaction with the nicotinamide adenine dinucleotide-dependent (NAD-dependent) deacetylase sirtuin 1 (Sirt1), sustained the acetylated state of FoxO1, and made FoxO1 nicotinamide and resveratrol insensitive, supporting a role for this motif in Sirt1 binding. NAD 82-115 sirtuin 1 Mus musculus 154-163 16917544-6 2006 Importantly, mutagenesis of the LXXLL motif eliminated FoxO1 interaction with the nicotinamide adenine dinucleotide-dependent (NAD-dependent) deacetylase sirtuin 1 (Sirt1), sustained the acetylated state of FoxO1, and made FoxO1 nicotinamide and resveratrol insensitive, supporting a role for this motif in Sirt1 binding. NAD 82-115 sirtuin 1 Mus musculus 165-170 16917544-6 2006 Importantly, mutagenesis of the LXXLL motif eliminated FoxO1 interaction with the nicotinamide adenine dinucleotide-dependent (NAD-dependent) deacetylase sirtuin 1 (Sirt1), sustained the acetylated state of FoxO1, and made FoxO1 nicotinamide and resveratrol insensitive, supporting a role for this motif in Sirt1 binding. NAD 82-115 sirtuin 1 Mus musculus 307-312 16917544-6 2006 Importantly, mutagenesis of the LXXLL motif eliminated FoxO1 interaction with the nicotinamide adenine dinucleotide-dependent (NAD-dependent) deacetylase sirtuin 1 (Sirt1), sustained the acetylated state of FoxO1, and made FoxO1 nicotinamide and resveratrol insensitive, supporting a role for this motif in Sirt1 binding. NAD 127-130 sirtuin 1 Mus musculus 154-163 16917544-6 2006 Importantly, mutagenesis of the LXXLL motif eliminated FoxO1 interaction with the nicotinamide adenine dinucleotide-dependent (NAD-dependent) deacetylase sirtuin 1 (Sirt1), sustained the acetylated state of FoxO1, and made FoxO1 nicotinamide and resveratrol insensitive, supporting a role for this motif in Sirt1 binding. NAD 127-130 sirtuin 1 Mus musculus 307-312 15795229-1 2005 Members of the Sir2 family of NAD-dependent protein deacetylases regulate diverse cellular processes including aging, gene silencing, and cellular differentiation. NAD 30-33 sirtuin 1 Mus musculus 15-19 15381699-4 2004 In this study, we determined the kinetics of the NAD biosynthesis mediated by nicotinamide phosphoribosyltransferase (Nampt) and nicotinamide/nicotinic acid mononucleotide adenylyltransferase (Nmnat), and we examined its effects on the transcriptional regulatory function of the mouse Sir2 ortholog, Sir2alpha, in mouse fibroblasts. NAD 49-52 sirtuin 1 Mus musculus 285-289 15381699-4 2004 In this study, we determined the kinetics of the NAD biosynthesis mediated by nicotinamide phosphoribosyltransferase (Nampt) and nicotinamide/nicotinic acid mononucleotide adenylyltransferase (Nmnat), and we examined its effects on the transcriptional regulatory function of the mouse Sir2 ortholog, Sir2alpha, in mouse fibroblasts. NAD 49-52 sirtuin 1 Mus musculus 300-309 14706864-0 2004 Predominant expression of Sir2alpha, an NAD-dependent histone deacetylase, in the embryonic mouse heart and brain. NAD 40-43 sirtuin 1 Mus musculus 26-35 14523559-4 2003 Due to the NAD+ dependency, Sir2 might be the link between metabolic activity and histone/protein acetylation. NAD 11-15 sirtuin 1 Mus musculus 28-32 12899610-2 2003 The Sir2 enzymes are NAD(+)-dependent protein deacetylases that influence gene expression by forming deacetylated proteins, nicotinamide and 2"-O-acetyl-ADPR. NAD 21-25 sirtuin 1 Mus musculus 4-8