Title : Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+.

Pub. Date : 2007 May 4

PMID : 17482543






1 Functional Relationships(s)
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1 Although NAD(+) biosynthesis is required for Sir2 functions and replicative lifespan in yeast, alterations in NAD(+) precursors have been reported to accelerate aging but not to extend lifespan. NAD sirtuin 1 Mus musculus