Bortezomib

mitogen-activated protein kinase 8 ; Homo sapiens







38 Article(s)
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1 33674562 Ciclopirox and bortezomib synergistically inhibits glioblastoma multiforme growth via simultaneously enhancing JNK/p38 MAPK and NF-κB signaling. 2021 Mar 5 3
2 33787860 Antineoplastic and anti-inflammatory effects of bortezomib on systemic chronic active EBV infection. 2021 Apr 13 1
3 34144391 Proteasome dysfunction under compromised redox metabolism dictates liver injury in NASH through ASK1/PPARγ binodal complementary modules. 2021 Sep 1
4 29259009 Loss of RASSF4 Expression in Multiple Myeloma Promotes RAS-Driven Malignant Progression. 2018 Mar 1 1
5 29423023 Infliction of proteotoxic stresses by impairment of the unfolded protein response or proteasomal inhibition as a therapeutic strategy for mast cell leukemia. 2018 Jan 9 2
6 30094097 Trametinib suppresses chemotherapy-induced cold and mechanical allodynia via inhibition of extracellular-regulated protein kinase 1/2 activation. 2018 3
7 29026157 Bortezomib promotes KHSV and EBV lytic cycle by activating JNK and autophagy. 2017 Oct 12 2
8 27390350 Bortezomib Treatment Sensitizes Oncolytic HSV-1-Treated Tumors to NK Cell Immunotherapy. 2016 Nov 1 1
9 25602436 Bortezomib inhibits gastric carcinoma HGC-27 cells through the phospho-Jun N-terminal kinase (p-JNK) pathway in vitro. 2015 Apr 1 2
10 24190701 Bortezomib-induced apoptosis in cultured pancreatic cancer cells is associated with ceramide production. 2014 Jan 3
11 24486574 Role of Bcl-xL/Beclin-1 in interplay between apoptosis and autophagy in oxaliplatin and bortezomib-induced cell death. 2014 Mar 15 1
12 22006557 Involvement of mitogen-activated protein kinase in signal transducer and activator of transcription-1 mediated differentiation induced by bortezomib in acute myeloid leukemia cells. 2013 Jan 3
13 23079083 Bortezomib/proteasome inhibitor triggers both apoptosis and autophagy-dependent pathways in melanoma cells. 2013 Jan 2
14 24086672 JNK and macroautophagy activation by bortezomib has a pro-survival effect in primary effusion lymphoma cells. 2013 4
15 24158003 Combination treatment with 2-methoxyestradiol overcomes bortezomib resistance of multiple myeloma cells. 2013 Oct 25 3
16 21732139 Inhibition of heat shock protein response enhances PS-341-mediated glioma cell death. 2012 Jul 1
17 21993018 Bortezomib induces autophagy in head and neck squamous cell carcinoma cells via JNK activation. 2012 Jan 1 6
18 22532603 Proteasome inhibition blocks NF-κB and ERK1/2 pathways, restores antigen expression, and sensitizes resistant human melanoma to TCR-engineered CTLs. 2012 Jun 1
19 22606012 Curcumin enhances cytotoxic effects of bortezomib in human multiple myeloma H929 cells: potential roles of NF-κB/JNK. 2012 1
20 22822672 [Effects of secoisolariciresinol diglucoside combined with bortezomib on induction of apoptosis in lung cancer cell line A549]. 2012 Feb 1
21 23257432 [Mechanism of apoptosis synergistically induced by bortezomib combined with cytarabine in U937 cell line]. 2012 Dec 1
22 21729547 [Effect of different concentrations of bortezomib on the expression of ERK, JNK and P38 in daunorubicin-resistant K562 cells]. 2011 Jun 5
23 21755010 Small compound 6-O-angeloylplenolin induces mitotic arrest and exhibits therapeutic potentials in multiple myeloma. 2011 1
24 22087283 The proteasome inhibitor bortezomib enhances ATRA-induced differentiation of neuroblastoma cells via the JNK mitogen-activated protein kinase pathway. 2011 2
25 19267218 Bmf is upregulated by PS-341-mediated cell death of glioma cells through JNK phosphorylation. 2010 Mar 1
26 19608275 Enhanced antimyeloma cytotoxicity by the combination of arsenic trioxide and bortezomib is further potentiated by p38 MAPK inhibition. 2010 Jan 1
27 21176351 [Effect of bortezomib on MAPK signaling pathway of K562/DNR cells]. 2010 Dec 2
28 19270531 Bcl-2 antagonists interact synergistically with bortezomib in DLBCL cells in association with JNK activation and induction of ER stress. 2009 May 4
29 18559525 The novel polyamine analogue CGC-11093 enhances the antimyeloma activity of bortezomib. 2008 Jun 15 2
30 16528474 JNK and AP-1 mediate apoptosis induced by bortezomib in HepG2 cells via FasL/caspase-8 and mitochondria-dependent pathways. 2006 Apr 3
31 16985072 Cytotoxic synergy between the multikinase inhibitor sorafenib and the proteasome inhibitor bortezomib in vitro: induction of apoptosis through Akt and c-Jun NH2-terminal kinase pathways. 2006 Sep 1
32 15531918 Proteasome inhibitor PS-341 causes cell growth arrest and apoptosis in human glioblastoma multiforme (GBM). 2005 Jan 13 1
33 15735676 Molecular characterization of PS-341 (bortezomib) resistance: implications for overcoming resistance using lysophosphatidic acid acyltransferase (LPAAT)-beta inhibitors. 2005 Apr 28 6
34 16357177 Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis. 2005 Dec 15 3
35 14965369 Proteasome inhibitor PS-341 induces growth arrest and apoptosis of non-small cell lung cancer cells via the JNK/c-Jun/AP-1 signaling. 2004 Feb 9
36 15093752 The hierarchical relationship between MAPK signaling and ROS generation in human leukemia cells undergoing apoptosis in response to the proteasome inhibitor Bortezomib. 2004 May 1 6
37 15217830 Targeting mitochondria to overcome conventional and bortezomib/proteasome inhibitor PS-341 resistance in multiple myeloma (MM) cells. 2004 Oct 15 5
38 12393500 Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341. 2003 Feb 15 3