Pub. Date : 2012 Jan 1
PMID : 21993018
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bortezomib induces autophagy in head and neck squamous cell carcinoma cells via JNK activation. | Bortezomib | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Bortezomib treatment led to phosphorylation/activation of jun N-terminal kinase (JNK) enzymes and JNK-dependent phosphorylation of Bcl-2 on serine 70. | Bortezomib | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | Bortezomib treatment led to phosphorylation/activation of jun N-terminal kinase (JNK) enzymes and JNK-dependent phosphorylation of Bcl-2 on serine 70. | Bortezomib | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | Bortezomib treatment led to phosphorylation/activation of jun N-terminal kinase (JNK) enzymes and JNK-dependent phosphorylation of Bcl-2 on serine 70. | Bortezomib | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | Pharmacologic inhibition of JNK, but not p38 MAPK, dramatically inhibited bortezomib induction of autophagy regulatory proteins and autophagosome formation. | Bortezomib | mitogen-activated protein kinase 8 | Homo sapiens |
| 6 | These results demonstrate a key requirement for JNK signaling in the activation of autophagy by bortezomib. | Bortezomib | mitogen-activated protein kinase 8 | Homo sapiens |