Title : The novel polyamine analogue CGC-11093 enhances the antimyeloma activity of bortezomib.

Pub. Date : 2008 Jun 15

PMID : 18559525






2 Functional Relationships(s)
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1 Furthermore, inhibition of JNK with a pharmacologic inhibitor or by selective knockdown blunted the efficacy of CGC-11093 and bortezomib. Bortezomib mitogen-activated protein kinase 8 Homo sapiens
2 Therefore, CGC-11093 enhances the anticancer activity of bortezomib by augmenting JNK-mediated apoptosis and blocking angiogenesis. Bortezomib mitogen-activated protein kinase 8 Homo sapiens