Title : Proteasome inhibition blocks NF-κB and ERK1/2 pathways, restores antigen expression, and sensitizes resistant human melanoma to TCR-engineered CTLs.

Pub. Date : 2012 Jun

PMID : 22532603






1 Functional Relationships(s)
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1 The proteasome inhibitor bortezomib blocked NF-kappaB activity, decreased phospho-ERK1/2, increased phospho-c-jun-NH(2)-kinase (p-JNK) levels, reduced expression of resistance factors, restored MART-1 expression to sufficient levels, which in combination allowed M244R lines be sensitized to F5 CTL killing. Bortezomib mitogen-activated protein kinase 8 Homo sapiens