Pub. Date : 2005 Dec 15
PMID : 16357177
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we show that bortezomib promotes apoptosis triggered by classic ER stress inducers (tunicamycin and thapsigargin) via a c-Jun NH(2)-terminal kinase (JNK)-dependent mechanism. | Bortezomib | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Here, we show that bortezomib promotes apoptosis triggered by classic ER stress inducers (tunicamycin and thapsigargin) via a c-Jun NH(2)-terminal kinase (JNK)-dependent mechanism. | Bortezomib | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | Importantly, combined therapy with bortezomib plus cisplatin induced JNK activation and apoptosis in orthotopic pancreatic tumors resulting in a reduction in tumor burden. | Bortezomib | mitogen-activated protein kinase 8 | Homo sapiens |