Fluorouracil

BCL2 apoptosis regulator ; Homo sapiens







127 Article(s)
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51 25855960 Histone acetyltransferase PCAF accelerates apoptosis by repressing a GLI1/BCL2/BAX axis in hepatocellular carcinoma. 2015 Apr 9 3
52 26051518 Bioreactor-engineered cancer tissue-like structures mimic phenotypes, gene expression profiles and drug resistance patterns observed "in vivo". 2015 Sep 2
53 26136123 Alpha 7-nicotinic acetylcholine receptor mediates the sensitivity of gastric cancer cells to 5-fluorouracil. 2015 Dec 3
54 26513239 MiR-429 Induces Gastric Carcinoma Cell Apoptosis Through Bcl-2. 2015 1
55 26692822 Arsenic trioxide reduces chemo-resistance to 5-fluorouracil and cisplatin in HBx-HepG2 cells via complex mechanisms. 2015 1
56 24210071 Morphine improved the antitumor effects on MCF-7 cells in combination with 5-Fluorouracil. 2014 Apr 1
57 24239278 p27 and BCL2 expression predicts response to chemotherapy in head and neck squamous cell carcinomas. 2014 Feb 1
58 24515389 Regulatory mechanism of ZNF139 in multi-drug resistance of gastric cancer cells. 2014 Jun 1
59 24733045 JNK confers 5-fluorouracil resistance in p53-deficient and mutant p53-expressing colon cancer cells by inducing survival autophagy. 2014 Apr 15 2
60 24751000 Gene expression profile of 5-fluorouracil metabolic enzymes in laryngeal cancer cell line: predictive parameters for response to 5-fluorouracil-based chemotherapy. 2014 Jun 1
61 25019346 Knockdown of EpCAM enhances the chemosensitivity of breast cancer cells to 5-fluorouracil by downregulating the antiapoptotic factor Bcl-2. 2014 1
62 25087947 Synergistic effects of 5-fluorouracil and gambogenic acid on A549 cells: activation of cell death caused by apoptotic and necroptotic mechanisms via the ROS-mitochondria pathway. 2014 1
63 25230779 Overexpression of CD133 enhances chemoresistance to 5-fluorouracil by activating the PI3K/Akt/p70S6K pathway in gastric cancer cells. 2014 Dec 1
64 23076534 Upregulation of periostin prevents P53-mediated apoptosis in SGC-7901 gastric cancer cells. 2013 Feb 1
65 23426065 Characterization of side population cells isolated from the gastric cancer cell line SGC-7901. 2013 Mar 1
66 23684481 Bcl-2 gene silence enhances the sensitivity toward 5-Fluorouracil in gastric adenocarcinoma cells. 2013 Sep 5
67 23784204 Bcl-2 gene silencing by RNA interference inhibits the growth of the human gallbladder carcinoma cell line GBC-SD in vitro and in vivo. 2013 Aug 1
68 24161202 CpG oligodeoxynucleotides enhance chemosensitivity of 5-fluorouracil in HepG2 human hepatoma cells via downregulation of the antiapoptotic factors survivin and livin. 2013 Oct 26 1
69 24228120 Correlation between chemosensitivity to anticancer drugs and Bcl-2 expression in gastric cancer. 2013 2
70 24363520 Cooperative inhibitory effect of sinomenine combined with 5-fluorouracil on esophageal carcinoma. 2013 Dec 7 1
71 22206670 Thymoquinone inhibits growth and augments 5-fluorouracil-induced apoptosis in gastric cancer cells both in vitro and in vivo. 2012 Jan 13 1
72 22366766 EBP50 gene transfection promotes 5-fluorouracil-induced apoptosis in gastric cancer cells through Bax- and Bcl-2-triggered mitochondrial pathways. 2012 May 1
73 22590561 Constitutive and treatment-induced CXCL8-signalling selectively modulates the efficacy of anti-metabolite therapeutics in metastatic prostate cancer. 2012 1
74 22607196 Oroxylin A improves the sensitivity of HT-29 human colon cancer cells to 5-FU through modulation of the COX-2 signaling pathway. 2012 Aug 1
75 22825128 Oleanolic acid potentiates the antitumor activity of 5-fluorouracil in pancreatic cancer cells. 2012 Oct 1
76 23108049 DUSP6 is a novel transcriptional target of p53 and regulates p53-mediated apoptosis by modulating expression levels of Bcl-2 family proteins. 2012 Nov 30 1
77 23152059 miR-204 targets Bcl-2 expression and enhances responsiveness of gastric cancer. 2012 Nov 15 2
78 21375586 Ghrelin inhibits 5-fluorouracil-induced apoptosis in colonic cancer cells. 2011 Jul 2
79 21403907 Synergistic antitumor effect of dichloroacetate in combination with 5-fluorouracil in colorectal cancer. 2011 1
80 21878904 A double-modulation strategy in cancer treatment with a chemotherapeutic agent and siRNA. 2011 Nov 3
81 22216150 Induction of Bcl-2 expression by hepatitis B virus pre-S2 mutant large surface protein resistance to 5-fluorouracil treatment in Huh-7 cells. 2011 4
82 22312705 MiR-122 increases sensitivity of drug-resistant BEL-7402/5-FU cells to 5-fluorouracil via down-regulation of bcl-2 family proteins. 2011 Dec 1
83 19585117 Synergistic effect of 5-fluorouracil and the flavanoid oroxylin A on HepG2 human hepatocellular carcinoma and on H22 transplanted mice. 2010 Feb 1
84 19810096 Combination of p53 codon 72 polymorphism and inactive p53 mutation predicts chemosensitivity to 5-fluorouracil in colorectal cancer. 2010 Apr 1 2
85 19903580 Triptolide simultaneously induces reactive oxygen species, inhibits NF-kappaB activity and sensitizes 5-fluorouracil in colorectal cancer cell lines. 2010 May 28 1
86 20514446 Implication of necrosis-linked p53 aggregation in acquired apoptotic resistance to 5-FU in MCF-7 multicellular tumour spheroids. 2010 Jul 1
87 20633010 Low-dose 5-fluorouracil induces cell cycle G2 arrest and apoptosis in keloid fibroblasts. 2010 Dec 1
88 20691103 Expression of the apoptosis-related genes BCL-2 and BAD in human breast carcinoma and their associated relationship with chemosensitivity. 2010 Aug 7 1
89 20704765 LY294002 may overcome 5-FU resistance via down-regulation of activated p-AKT in Epstein-Barr virus-positive gastric cancer cells. 2010 Aug 13 2
90 22811811 Bax expression is a candidate prognostic and predictive marker of colorectal cancer. 2010 Dec 1
91 19843160 MicroRNA-143 reduces viability and increases sensitivity to 5-fluorouracil in HCT116 human colorectal cancer cells. 2009 Nov 1
92 18082672 The immunocytokine scFv23/TNF targeting HER-2/neu induces synergistic cytotoxic effects with 5-fluorouracil in TNF-resistant pancreatic cancer cell lines. 2008 Feb 15 1
93 18478476 [Anti-tumor effect of chemotherapeutic drugs on human gastric cancer cells in vitro and the relationship with Bcl-2 expression]. 2008 May 1
94 18704308 The effect of targeted magnetic nanopaticles on hepatoma and the expression of bcl-2/bax protein. 2008 Aug 2
95 18949393 Oncoprotein Bcl-2 and microsatellite instability are associated with disease-free survival and treatment response in colorectal cancer. 2008 Nov 1
96 19000447 [Correlation of expression of P-glycoprotein and inhibitor of apoptosis proteins to chemosensitivity in gastrointestinal carcinoma tissues]. 2008 Nov 2
97 17439414 siRNA-mediated Bcl-2 and Bcl-xl gene silencing sensitizes human hepatoblastoma cells to chemotherapeutic drugs. 2007 May-Jun 1
98 17537404 Drug resistance to 5-FU linked to reactive oxygen species modulator 1. 2007 Jul 27 1
99 15996812 DNA damaging drugs-induced down-regulation of Bcl-2 is essential for induction of apoptosis in high-risk HPV-positive HEp-2 and KB cells. 2006 May 18 1
100 16391804 in vitro synergistic antitumor activity of a combination of 5-fluorouracil and irinotecan in human colon cancer. 2006 Feb 1