Title : JNK confers 5-fluorouracil resistance in p53-deficient and mutant p53-expressing colon cancer cells by inducing survival autophagy.

Pub. Date : 2014 Apr 15

PMID : 24733045






2 Functional Relationships(s)
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1 In further analysis, we show that JNK activation and phosphorylation of Bcl-2 are key determinants in 5-FU-induced autophagy. Fluorouracil BCL2 apoptosis regulator Homo sapiens
2 Taken together, our results suggest that JNK activation confers 5-FU resistance in HCT116 p53(-/-) and HT29 cells by promoting autophagy as a pro-survival effect, likely via inducing Bcl-2 phosphorylation. Fluorouracil BCL2 apoptosis regulator Homo sapiens