| 1 |
33034275 | Mutational landscape of K-Ras substitutions at 12th position-a systematic molecular dynamics approach. | 2022 Mar |
1 |
| 2 |
34787842 | 1 H, 15 N and 13 C resonance assignments of the Q61H mutant of human KRAS bound to GDP. | 2022 Apr |
2 |
| 3 |
35075146 | KRAS(G12D) can be targeted by potent inhibitors via formation of salt bridge. | 2022 Jan 25 |
2 |
| 4 |
35267628 | Direct Targeting KRAS Mutation in Non-Small Cell Lung Cancer: Focus on Resistance. | 2022 Mar 4 |
2 |
| 5 |
35314814 | KRAS is vulnerable to reversible switch-II pocket engagement in cells. | 2022 Jun |
3 |
| 6 |
35561303 | More to the RAS Story: KRASG12C Inhibition, Resistance Mechanisms, and Moving Beyond KRASG12C. | 2022 Apr |
1 |
| 7 |
35573474 | Inhibitor of the Nuclear Transport Protein XPO1 Enhances the Anticancer Efficacy of KRAS G12C Inhibitors in Preclinical Models of KRAS G12C-Mutant Cancers. | 2022 May |
1 |
| 8 |
35614853 | Structural and biophysical properties of farnesylated KRas interacting with the chaperone SmgGDS-558. | 2022 May 25 |
1 |
| 9 |
33680360 | Mechanistic insights into the effect of phosphorylation on Ras conformational dynamics and its interactions with cell signaling proteins. | 2021 |
1 |
| 10 |
33739090 | Mutation-Induced Impacts on the Switch Transformations of the GDP- and GTP-Bound K-Ras: Insights from Multiple Replica Gaussian Accelerated Molecular Dynamics and Free Energy Analysis. | 2021 Apr 26 |
8 |
| 11 |
33978412 | Normal Mode Analysis of KRas4B Reveals Partner Specific Dynamics. | 2021 May 27 |
1 |
| 12 |
34247129 | Conformational transformation of switch domains in GDP/K-Ras induced by G13 mutants: An investigation through Gaussian accelerated molecular dynamics simulations and principal component analysis. | 2021 Aug |
3 |
| 13 |
31468366 | 1H, 15N backbone assignment and comparative analysis of the wild type and G12C, G12D, G12V mutants of K-Ras bound to GDP at physiological pH. | 2020 Apr |
2 |
| 14 |
31658955 | The KRASG12C Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients. | 2020 Jan |
1 |
| 15 |
32176377 | Targeting Krasg12c -mutant cancer with a mutation-specific inhibitor. | 2020 Aug |
1 |
| 16 |
32227412 | Two Distinct Structures of Membrane-Associated Homodimers of GTP- and GDP-Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement. | 2020 Jun 26 |
2 |
| 17 |
32486141 | A H-REV107 Peptide Inhibits Tumor Growth and Interacts Directly with Oncogenic KRAS Mutants. | 2020 May 30 |
4 |
| 18 |
32686745 | KRAS(G12C)-AMG 510 interaction dynamics revealed by all-atom molecular dynamics simulations. | 2020 Jul 20 |
2 |
| 19 |
32715349 | Structure-based inhibitor design of mutant RAS proteins-a paradigm shift. | 2020 Dec |
2 |
| 20 |
33145412 | GTP-State-Selective Cyclic Peptide Ligands of K-Ras(G12D) Block Its Interaction with Raf. | 2020 Oct 28 |
2 |
| 21 |
33153459 | Discernment between candidate mechanisms for KRAS G13D colorectal cancer sensitivity to EGFR inhibitors. | 2020 Nov 5 |
2 |
| 22 |
30798456 | NMR 1H,13C, 15N resonance assignment of the G12C mutant of human K-Ras bound to GppNHp. | 2019 Apr |
1 |
| 23 |
30971271 | Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy. | 2019 Apr 10 |
8 |
| 24 |
31324887 | Structures of N-terminally processed KRAS provide insight into the role of N-acetylation. | 2019 Jul 19 |
7 |
| 25 |
31339036 | PIP2 Influences the Conformational Dynamics of Membrane-Bound KRAS4b. | 2019 Aug 20 |
2 |
| 26 |
31341022 | Structural basis of the atypical activation mechanism of KRASV14I. | 2019 Sep 20 |
1 |
| 27 |
31409810 | Oncogenic G12D mutation alters local conformations and dynamics of K-Ras. | 2019 Aug 13 |
2 |
| 28 |
31853358 | Investigation of GTP-dependent dimerization of G12X K-Ras variants using ultraviolet photodissociation mass spectrometry. | 2019 Sep 14 |
2 |
| 29 |
29229665 | Ras and the Plasma Membrane: A Complicated Relationship. | 2018 Oct 1 |
2 |
| 30 |
29235861 | KRAS Switch Mutants D33E and A59G Crystallize in the State 1 Conformation. | 2018 Jan 23 |
1 |
| 31 |
29313669 | Design of Small Molecules That Compete with Nucleotide Binding to an Engineered Oncogenic KRAS Allele. | 2018 Feb 27 |
3 |
| 32 |
29721757 | NMR 1H,13C, 15N backbone and 13C side chain resonance assignment of the G12C mutant of human K-Ras bound to GDP. | 2018 Oct |
3 |
| 33 |
30097175 | Allosteric KRas4B Can Modulate SOS1 Fast and Slow Ras Activation Cycles. | 2018 Aug 21 |
8 |
| 34 |
27820802 | Inhibition of RAS function through targeting an allosteric regulatory site. | 2017 Jan |
1 |
| 35 |
28153726 | K-Ras(G12D)-selective inhibitory peptides generated by random peptide T7 phage display technology. | 2017 Mar 11 |
1 |
| 36 |
28740607 | Crystal Structure of a Human K-Ras G12D Mutant in Complex with GDP and the Cyclic Inhibitory Peptide KRpep-2d. | 2017 Jul 13 |
2 |
| 37 |
29033317 | Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States. | 2017 Dec 21 |
1 |
| 38 |
29199977 | Structural insight into the rearrangement of the switch I region in GTP-bound G12A K-Ras. | 2017 Dec 1 |
3 |
| 39 |
26629855 | Covalent targeting of acquired cysteines in cancer. | 2016 Feb |
1 |
| 40 |
26739882 | Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State. | 2016 Mar |
2 |
| 41 |
26761128 | Comparison of the Conformations of KRAS Isoforms, K-Ras4A and K-Ras4B, Points to Similarities and Significant Differences. | 2016 Feb 4 |
3 |
| 42 |
26854235 | KRAS Engages AGO2 to Enhance Cellular Transformation. | 2016 Feb 16 |
1 |
| 43 |
26902995 | The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B. | 2016 Feb 23 |
5 |
| 44 |
26960760 | K-Ras protein as a drug target. | 2016 Mar |
1 |
| 45 |
27665622 | Impact of G12 Mutations on the Structure of K-Ras Probed by Ultraviolet Photodissociation Mass Spectrometry. | 2016 Oct 12 |
4 |
| 46 |
26037647 | Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations. | 2015 Sep |
1 |
| 47 |
26453300 | GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site. | 2015 Nov 27 |
3 |
| 48 |
24259466 | Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor. | 2014 Jan 3 |
1 |
| 49 |
22886485 | ¹H, ¹³C and ¹⁵N resonance assignment for the human K-Ras at physiological pH. | 2013 Oct |
1 |
| 50 |
24256730 | K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. | 2013 Nov 28 |
1 |