Title : Design of Small Molecules That Compete with Nucleotide Binding to an Engineered Oncogenic KRAS Allele.

Pub. Date : 2018 Feb 27

PMID : 29313669






3 Functional Relationships(s)
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1 However, directly targeting oncogenic KRAS with small molecules in the nucleotide-binding site has been difficult because of the high affinity of KRAS for GDP and GTP. Guanosine Diphosphate KRAS proto-oncogene, GTPase Homo sapiens
2 However, directly targeting oncogenic KRAS with small molecules in the nucleotide-binding site has been difficult because of the high affinity of KRAS for GDP and GTP. Guanosine Diphosphate KRAS proto-oncogene, GTPase Homo sapiens
3 We designed an engineered allele of KRAS and a covalent inhibitor that competes for GTP and GDP. Guanosine Diphosphate KRAS proto-oncogene, GTPase Homo sapiens