Pub. Date : 2020 Oct 28
PMID : 33145412
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | These cyclic peptides show preferential binding to the GTP-bound state of K-Ras(G12D) over the GDP-bound state and block Ras-Raf interaction. | Guanosine Diphosphate | KRAS proto-oncogene, GTPase | Homo sapiens |
| 2 | The union of G12D over wildtype selectivity and GTP state/GDP state selectivity is particularly desirable, considering that oncogenic K-Ras(G12D) exists predominantly in the GTP state in cancer cells, and wildtype K-Ras signaling is important for the maintenance of healthy cells. | Guanosine Diphosphate | KRAS proto-oncogene, GTPase | Homo sapiens |