Title : Two Distinct Structures of Membrane-Associated Homodimers of GTP- and GDP-Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement.

Pub. Date : 2020 Jun 26

PMID : 32227412






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1 Two Distinct Structures of Membrane-associated Homodimers of GTP- and GDP-bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement. Guanosine Diphosphate KRAS proto-oncogene, GTPase Homo sapiens
2 We developed a system to study KRAS dimerization on nanodiscs using paramagnetic relaxation enhancement (PRE) NMR, and determined distinct structures of membrane-anchored KRAS dimers in the active GTP- and inactive GDP-loaded states. Guanosine Diphosphate KRAS proto-oncogene, GTPase Homo sapiens