Title : FGFR1 overexpression renders breast cancer cells resistant to metformin through activation of IRS1/ERK signaling.

Pub. Date : 2021 Jan

PMID : 33007330






2 Functional Relationships(s)
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1 In particular, we found that, in addition to AKT and ERK1/2 activation, FGFR1-induced activation of IRS1 and IGF1R, key regulators connecting metabolism and cancer, was associated with metformin resistance. Metformin insulin like growth factor 1 receptor Homo sapiens
2 Combination of NT157 with metformin induced enhanced inhibition of p-IGF1R, p-ERK1/2 and p-mTOR. Metformin insulin like growth factor 1 receptor Homo sapiens