Title : Potent anti-proliferative effects of metformin on trastuzumab-resistant breast cancer cells via inhibition of erbB2/IGF-1 receptor interactions.

Pub. Date : 2011 Sep 1

PMID : 21862872






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Metformin disrupts erbB2/IGF-1R complexes, erbB3 and IGF-1R expression and activity, as well as Src kinase and/or PI-3K/Akt signaling. Metformin insulin like growth factor 1 receptor Homo sapiens
2 Metformin disrupts erbB2/IGF-1R complexes, erbB3 and IGF-1R expression and activity, as well as Src kinase and/or PI-3K/Akt signaling. Metformin insulin like growth factor 1 receptor Homo sapiens