Pub. Date : 2015
PMID : 25640355
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin down-regulates endometrial carcinoma cell secretion of IGF-1 and expression of IGF-1R. | Metformin | insulin like growth factor 1 receptor | Homo sapiens |
| 2 | IGF-1R was highly expressed in human endometrial carcinoma paraffin sections, but IGF-1R and phosphor-protein kinase B/protein kinase B (p-Akt/ Akt) expression was down-regulated after metformin treatment (p<0.05). | Metformin | insulin like growth factor 1 receptor | Homo sapiens |
| 3 | In summary, metformin can reduce the secretion of IGF-1 by Ishikawa and JEC EC cell lines and their expression of IGF-1R to deactivate downstream signaling involving the PI-3K/Akt pathway to inhibit endometrial carcinoma cell growth. | Metformin | insulin like growth factor 1 receptor | Homo sapiens |