Pub. Date : 2016 Aug 4
PMID : 27488947
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin Enhances the Therapy Effects of Anti-IGF-1R mAb Figitumumab to NSCLC. | Metformin | insulin like growth factor 1 receptor | Homo sapiens |
| 2 | Metformin could target IGF-1R signaling pathway by attenuating PI3K/AKT and MEK/ERK signaling pathways and down-regulating IGF-1R. | Metformin | insulin like growth factor 1 receptor | Homo sapiens |
| 3 | Metformin could target IGF-1R signaling pathway by attenuating PI3K/AKT and MEK/ERK signaling pathways and down-regulating IGF-1R. | Metformin | insulin like growth factor 1 receptor | Homo sapiens |
| 4 | Finally, we found that combining metformin with CP could further induce IGF-1R down-regulation and was more effective to target NSCLC cells. | Metformin | insulin like growth factor 1 receptor | Homo sapiens |