2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one

mitogen-activated protein kinase kinase 1 ; Homo sapiens







451 Article(s)
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1 32747685 GINS2 promotes EMT in pancreatic cancer via specifically stimulating ERK/MAPK signaling. 2021 Aug 1
2 31988090 FAM172A inhibits EMT in pancreatic cancer via ERK-MAPK signaling. 2020 Feb 7 1
3 32007501 Antidepressants induce profibrotic responses via the lysophosphatidic acid receptor LPA1. 2020 Apr 15 1
4 32438692 APE1 Promotes Pancreatic Cancer Proliferation through GFRα1/Src/ERK Axis-Cascade Signaling in Response to GDNF. 2020 May 19 1
5 32636633 Novel Melatonin, Estrogen, and Progesterone Hormone Therapy Demonstrates Anti-Cancer Actions in MCF-7 and MDA-MB-231 Breast Cancer Cells. 2020 1
6 32692865 Tight junction protein claudin-1 is downregulated by TGF-β1 via MEK signaling in benign prostatic epithelial cells. 2020 Oct 1
7 33163285 DUSP9-mediated reduction of pERK1/2 supports cancer stem cell-like traits and promotes triple negative breast cancer. 2020 1
8 31093311 CIAPIN1 Targeted NHE1 and ERK1/2 to Suppress NSCLC Cells' Metastasis and Predicted Good Prognosis in NSCLC Patients Receiving Pulmonectomy. 2019 1
9 28918684 Differential induction of c-Fos and phosphorylated ERK by a noxious stimulus after peripheral nerve injury. 2018 Mar 1
10 29416002 EZH2 inhibits autophagic cell death of aortic vascular smooth muscle cells to affect aortic dissection. 2018 Feb 7 1
11 29615689 Involvement of RSK1 activation in malformin-enhanced cellular fibrinolytic activity. 2018 Apr 3 1
12 30081092 The TGFβ-ERK pathway contributes to Notch3 upregulation in the renal tubular epithelial cells of patients with obstructive nephropathy. 2018 Nov 4
13 30192802 EGFR signaling suppresses type 1 cytokine-induced T-cell attracting chemokine secretion in head and neck cancer. 2018 1
14 28223944 IL-1β-Induced Downregulation of the Multifunctional PDZ Adaptor PDZK1 Is Attenuated by ERK Inhibition, RXRα, or PPARα Stimulation in Enterocytes. 2017 1
15 28445005 Proteomic-based investigations on the mode of action of the marine anticancer compound rhizochalinin. 2017 Jun 1
16 28968596 Resveratrol Inhibits the Epidermal Growth Factor-Induced Migration of Osteoblasts: the Suppression of SAPK/JNK and Akt. 2017 1
17 29267213 Praeruptorin A Inhibits Human Cervical Cancer Cell Growth and Invasion by Suppressing MMP-2 Expression and ERK1/2 Signaling. 2017 Dec 21 1
18 26483408 Activation of the Classical Mitogen-Activated Protein Kinases Is Part of the Shiga Toxin-Induced Ribotoxic Stress Response and May Contribute to Shiga Toxin-Induced Inflammation. 2016 Jan 1
19 26657209 Identification of intracellular pathways through which TGF-β1 upregulates URG-4/URGCP gene expression in hepatoma cells. 2016 Jan 1 1
20 27169363 A Phos-tag SDS-PAGE method that effectively uses phosphoproteomic data for profiling the phosphorylation dynamics of MEK1. 2016 Jul 2
21 27181679 MEK2 controls the activation of MKK3/MKK6-p38 axis involved in the MDA-MB-231 breast cancer cell survival: Correlation with cyclin D1 expression. 2016 Sep 3
22 27394658 Cry1Ac toxin induces macrophage activation via ERK1/2, JNK and p38 mitogen-activated protein kinases. 2016 Sep 1
23 27582276 Epigenetic regulation of transcription factor promoter regions by low-dose genistein through mitogen-activated protein kinase and mitogen-and-stress activated kinase 1 nongenomic signaling. 2016 Aug 31 1
24 27677171 In search for geroprotectors: in silico screening and in vitro validation of signalome-level mimetics of young healthy state. 2016 Sep 24 1
25 27693704 Astaxanthin enhances pemetrexed-induced cytotoxicity by downregulation of thymidylate synthase expression in human lung cancer cells. 2016 Nov 1
26 25724898 CIAPIN1 targets Na⁺/H⁺ exchanger 1 to mediate MDA-MB-231 cells' metastasis through regulation of MMPs via ERK1/2 signaling pathway. 2015 Apr 10 1
27 25968898 CBP-dependent Wnt/β-catenin signaling is crucial in regulation of MDR1 transcription. 2015 1
28 26422459 Quantitative proteomics unveiled: Regulation of DNA double strand break repair by EGFR involves PARP1. 2015 Sep 1
29 26502720 Suppression of MAPK attenuates neuronal cell death induced by activated glia-conditioned medium in alpha-synuclein overexpressing SH-SY5Y cells. 2015 Oct 26 1
30 26526356 A Her2-let-7-β2-AR circuit affects prognosis in patients with Her2-positive breast cancer. 2015 Nov 2 1
31 26640583 Chenodeoxycholic acid increases the induction of CYP1A1 in HepG2 and H4IIE cells. 2015 Nov 1
32 24247909 Purified vitexin compound 1 induces apoptosis through activation of FOXO3a in hepatocellular carcinoma. 2014 Jan 1
33 24434427 CD44 targets Na(+)/H(+) exchanger 1 to mediate MDA-MB-231 cells' metastasis via the regulation of ERK1/2. 2014 Feb 18 1
34 24466036 Fisetin inhibits human melanoma cell invasion through promotion of mesenchymal to epithelial transition and by targeting MAPK and NFκB signaling pathways. 2014 1
35 24732598 Deferoxamine promotes MDA-MB-231 cell migration and invasion through increased ROS-dependent HIF-1α accumulation. 2014 1
36 25078316 Towards the development of chromone-based MEK1/2 modulators. 2014 Oct 6 2
37 23237828 Cycloheximide stimulates suppressor of cytokine signaling-3 gene expression in 3T3-L1 adipocytes via the extracellular signal-regulated kinase pathway. 2013 Feb 13 1
38 23262982 Preventing MEK1 activation influences the responses of human osteosarcoma cells to bone morphogenetic proteins 2 and 9. 2013 Mar 1
39 23468877 Aquaporin3 is required for FGF-2-induced migration of human breast cancers. 2013 1
40 23532091 Curcumin induces cross-regulation between autophagy and apoptosis in uterine leiomyosarcoma cells. 2013 Jun 1
41 23569426 Proliferation enhanced by NGF-NTRK1 signaling makes pancreatic cancer cells more sensitive to 2DG-induced apoptosis. 2013 3
42 23820731 A new model to evaluate Raf signaling in hematopoietic cells. 2013 Sep 1
43 23848362 Off-target effects of MEK inhibitors. 2013 Aug 6 1
44 23948751 Reversal of boswellic acid analog BA145 induced caspase dependent apoptosis by PI3K inhibitor LY294002 and MEK inhibitor PD98059. 2013 Dec 1
45 23988606 CCN2 promotes keratinocyte adhesion and migration via integrin α5β1. 2013 Nov 15 1
46 24159358 P90RSK and Nrf2 Activation via MEK1/2-ERK1/2 Pathways Mediated by Notoginsenoside R2 to Prevent 6-Hydroxydopamine-Induced Apoptotic Death in SH-SY5Y Cells. 2013 1
47 24211253 MEK1 promotes YAP and their interaction is critical for tumorigenesis in liver cancer. 2013 Dec 11 1
48 22076613 Tissue factor/activated factor VIIa induces matrix metalloproteinase-7 expression through activation of c-Fos via ERK1/2 and p38 MAPK signaling pathways in human colon cancer cell. 2012 Apr 1
49 22172629 Flavonoids exhibit diverse effects on CYP11B1 expression and cortisol synthesis. 2012 Feb 1 1
50 22173130 Cobalt(II) β-ketoaminato complexes as novel inhibitors of neuroinflammation. 2012 Feb 15 1