Title : IL-1β-Induced Downregulation of the Multifunctional PDZ Adaptor PDZK1 Is Attenuated by ERK Inhibition, RXRα, or PPARα Stimulation in Enterocytes.

Pub. Date : 2017

PMID : 28223944






1 Functional Relationships(s)
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1 ERK1/2 inhibition by the specific MEK1/2 inhibitors PD98059/U0126 significantly attenuated the IL-1beta mediated downregulation of PDZK1, while NF-kappaB, p38 MAPK, and JNK inhibition did not. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one mitogen-activated protein kinase kinase 1 Homo sapiens