Title : A Her2-let-7-β2-AR circuit affects prognosis in patients with Her2-positive breast cancer.

Pub. Date : 2015 Nov 2

PMID : 26526356






1 Functional Relationships(s)
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1 The treatment with MEK1/2 inhibitors PD98059 or PD184352 effectively restored the let-7f level, suggesting that Her2-overexpression-mediated ERK constitutive activation inhibited let-7f, leading to the upregulation of the beta2-AR expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one mitogen-activated protein kinase kinase 1 Homo sapiens