r-2-hydroxyglutarate

isocitrate dehydrogenase (NADP(+)) 1 ; Homo sapiens







19 Article(s)
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1 35226770 Biology of IDH mutant cholangiocarcinoma. 2022 May 1
2 35609569 Dysfunctional dendritic cells limit antigen-specific T cell response in glioma. 2022 May 24 1
3 34183306 IDH-Mutant Brain Tumors Hit the Achilles' Heel of Macrophages with R-2-Hydroxyglutarate. 2021 Aug 2
4 34188585 Efficacy and Safety Profile of Ivosidenib in the Management of Patients with Acute Myeloid Leukemia (AML): An Update on the Emerging Evidence. 2021 1
5 32882760 All-Trans Retinoic Acid Synergizes with Enasidenib to Induce Differentiation of IDH2-Mutant Acute Myeloid Leukemia Cells. 2020 Sep 2
6 32955829 Enasidenib and ivosidenib in AML. 2020 Oct 1
7 30643428 Evaluating ivosidenib for the treatment of relapsed/refractory AML: design, development, and place in therapy. 2019 1
8 29249359 R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling. 2018 Jan 11 1
9 28132785 Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity. 2017 Mar 7 1
10 28319047 Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas. 2017 Apr 3 1
11 28711227 Oncogenic Activities of IDH1/2 Mutations: From Epigenetics to Cellular Signaling. 2017 Oct 1
12 26691210 Integration of 2-hydroxyglutarate-proton magnetic resonance spectroscopy into clinical practice for disease monitoring in isocitrate dehydrogenase-mutant glioma. 2016 Feb 2
13 27245312 Evidence for Clinical Differentiation and Differentiation Syndrome in Patients With Acute Myeloid Leukemia and IDH1 Mutations Treated With the Targeted Mutant IDH1 Inhibitor, AG-120. 2016 Aug 1
14 27577048 The oncometabolite R-2-hydroxyglutarate activates NF-κB-dependent tumor-promoting stromal niche for acute myeloid leukemia cells. 2016 Aug 31 2
15 27624942 The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway. 2016 Sep 14 1
16 26007236 Reductive carboxylation and 2-hydroxyglutarate formation by wild-type IDH2 in breast carcinoma cells. 2015 Aug 1
17 26147657 Role of isocitrate dehydrogenase 1/2 (IDH 1/2) gene mutations in human tumors. 2015 Oct 2
18 23518346 R-2-hydroxyglutarate as the key effector of IDH mutations promoting oncogenesis. 2013 Mar 18 2
19 23558169 An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. 2013 May 3 1