Title : The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway.

Pub. Date : 2016 Sep 14

PMID : 27624942






1 Functional Relationships(s)
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Protein Name
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1 In gliomas and acute myeloid leukaemias, IDH1/2 mutations confer gain-of-function leading to production of the oncometabolite R-2-hydroxyglutarate (2HG) from alphaKG. r-2-hydroxyglutarate isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens