Title : Integration of 2-hydroxyglutarate-proton magnetic resonance spectroscopy into clinical practice for disease monitoring in isocitrate dehydrogenase-mutant glioma.

Pub. Date : 2016 Feb

PMID : 26691210






2 Functional Relationships(s)
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1 BACKGROUND: The majority of WHO grades II and III gliomas harbor a missense mutation in the metabolic gene isocitrate dehydrogenase (IDH) and accumulate the metabolite R-2-hydroxyglutarate (R-2HG). r-2-hydroxyglutarate isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens
2 BACKGROUND: The majority of WHO grades II and III gliomas harbor a missense mutation in the metabolic gene isocitrate dehydrogenase (IDH) and accumulate the metabolite R-2-hydroxyglutarate (R-2HG). r-2-hydroxyglutarate isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens