Title : The oncometabolite R-2-hydroxyglutarate activates NF-κB-dependent tumor-promoting stromal niche for acute myeloid leukemia cells.

Pub. Date : 2016 Aug 31

PMID : 27577048






2 Functional Relationships(s)
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Protein Name
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1 Mutations of isocitrate dehydrogenase 1 (IDH1) and IDH2 in acute myeloid leukemia (AML) cells produce the oncometabolite R-2-hydroxyglutarate (R-2HG) to induce epigenetic alteration and block hematopoietic differentiation. r-2-hydroxyglutarate isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens
2 Mutations of isocitrate dehydrogenase 1 (IDH1) and IDH2 in acute myeloid leukemia (AML) cells produce the oncometabolite R-2-hydroxyglutarate (R-2HG) to induce epigenetic alteration and block hematopoietic differentiation. r-2-hydroxyglutarate isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens