BTB and CNC homology 1, basic leucine zipper transcription factor 1 ; Mus musculus






53 Article(s)
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1 12356737 Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene. EMBO J 2002 Oct 1 3
2 14747657 Heme regulates the dynamic exchange of Bach1 and NF-E2-related factors in the Maf transcription factor network. Proc Natl Acad Sci U S A 2004 Feb 10 3
3 15743416 Effects of genetic ablation of bach1 upon smooth muscle cell proliferation and atherosclerosis after cuff injury. Genes Cells 2005 Mar 2
4 15809329 Dynamic cytoplasmic anchoring of the transcription factor Bach1 by intracellular hyaluronic acid binding protein IHABP. J Biochem 2005 Mar 2
5 16824198 Genetic ablation of the transcription repressor Bach1 leads to myocardial protection against ischemia/reperfusion in mice. Genes Cells 2006 Jul 2
6 17682061 Heme induces ubiquitination and degradation of the transcription factor Bach1. Mol Cell Biol 2007 Oct 13
7 18271013 Oxidative stress reaction in the meniscus of Bach 1 deficient mice: potential prevention of meniscal degeneration. J Orthop Res 2008 Jun 1
8 18426999 Myocardial protection against pressure overload in mice lacking Bach1, a transcriptional repressor of heme oxygenase-1. Hypertension 2008 Jun 2
9 18633191 Ablation of the bach1 gene leads to the suppression of atherosclerosis in bach1 and apolipoprotein E double knockout mice. Hypertens Res 2008 Apr 3
10 19011633 Bach1 inhibits oxidative stress-induced cellular senescence by impeding p53 function on chromatin. Nat Struct Mol Biol 2008 Dec 4
11 19035757 Modulation of the secondary injury process after spinal cord injury in Bach1-deficient mice by heme oxygenase-1. J Neurosurg Spine 2008 Dec 1
12 20179090 Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position -7007 of the FPN1 promoter. Haematologica 2010 Aug 1
13 20388958 Inhibition of Bach1 ameliorates indomethacin-induced intestinal injury in mice. J Physiol Pharmacol 2009 Dec 6
14 21373270 Bach1 gene ablation reduces steatohepatitis in mouse MCD diet model. J Clin Biochem Nutr 2011 Mar 2
15 21444915 Heme regulates B-cell differentiation, antibody class switch, and heme oxygenase-1 expression in B cells as a ligand of Bach2. Blood 2011 May 19 1
16 21473739 Suppression of indomethacin-induced apoptosis in the small intestine due to Bach1 deficiency. Free Radic Res 2011 Jun 6
17 22348305 Bach1-mediated suppression of p53 is inhibited by p19(ARF) independently of MDM2. Cancer Sci 2012 May 2
18 22847612 Bach1 is critical for the transformation of mouse embryonic fibroblasts by Ras(V12) and maintains ERK signaling. Oncogene 2013 Jul 4 4
19 23446334 BTB and CNC homolog 1 (Bach1) deficiency ameliorates TNBS colitis in mice: role of M2 macrophages and heme oxygenase-1. Inflamm Bowel Dis 2013 Mar-Apr 1
20 23479260 Hydrogen sulfide preconditions the db/db diabetic mouse heart against ischemia-reperfusion injury by activating Nrf2 signaling in an Erk-dependent manner. Am J Physiol Heart Circ Physiol 2013 May 1
21 23880309 Bach1 deficiency protects pancreatic β-cells from oxidative stress injury. Am J Physiol Endocrinol Metab 2013 Sep 1 2
22 24530569 5-Aminolevulinic acid combined with ferrous iron enhances the expression of heme oxygenase-1. Int Immunopharmacol 2014 Apr 4
23 25520741 Homocysteine downregulates gene expression of heme oxygenase-1 in hepatocytes. Nutr Metab (Lond) 2014 3
24 27030212 Genomewide approaches for BACH1 target genes in mouse embryonic fibroblasts showed BACH1-Pparg pathway in adipogenesis. Genes Cells 2016 Jun 2
25 27277809 Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease. J Neurosci 2016 Jun 8 2
26 27714264 Topical treatment of green tea polyphenols emulsified in carboxymethyl cellulose protects against acute ultraviolet light B-induced photodamage in hairless mice. Photochem Photobiol Sci 2016 Oct 5 1
27 27836987 RANKL induces Bach1 nuclear import and attenuates Nrf2-mediated antioxidant enzymes, thereby augmenting intracellular reactive oxygen species signaling and osteoclastogenesis in mice. FASEB J 2017 Feb 2
28 27927768 Iron-heme-Bach1 axis is involved in erythroblast adaptation to iron deficiency. Haematologica 2017 Mar 9
29 27959382 Bach1 siRNA attenuates bleomycin-induced pulmonary fibrosis by modulating oxidative stress in mice. Int J Mol Med 2017 Jan 1
30 28213091 Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBα/β activation in aryl hydrocarbon receptor-elicited hepatotoxicity. Toxicol Appl Pharmacol 2017 Apr 15 3
31 28420366 Pirfenidone attenuates bleomycin-induced pulmonary fibrosis in mice by regulating Nrf2/Bach1 equilibrium. BMC Pulm Med 2017 Apr 18 2
32 28808058 Reductions in the mitochondrial ABC transporter Abcb10 affect the transcriptional profile of heme biosynthesis genes. J Biol Chem 2017 Sep 29 1
33 29636091 Dysregulated heme oxygenase-1<sup>low</sup> M2-like macrophages augment lupus nephritis via Bach1 induced by type I interferons. Arthritis Res Ther 2018 Apr 10 2
34 30487665 Heme oxygenase-1 prevents murine intestinal inflammation. J Clin Biochem Nutr 2018 Nov 1
35 30535483 Salvianolic acid B, an antioxidant derived from Salvia militarize, protects mice against γ‑radiation‑induced damage through Nrf2/Bach1. Mol Med Rep 2019 Feb 1
36 30853683 Functional Heme Binding to the Intrinsically Disordered C-Terminal Region of Bach1, a Transcriptional Repressor. Tohoku J Exp Med 2019 Mar 6
37 31026585 TLR4 activation alters labile heme levels to regulate BACH1 and heme oxygenase-1 expression in macrophages. Free Radic Biol Med 2019 Jun 9
38 31257027 BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis. Cell 2019 Jul 11 2
39 31405954 The BACH1-HMOX1 Regulatory Axis Is Indispensable for Proper Macrophage Subtype Specification and Skeletal Muscle Regeneration. J Immunol 2019 Sep 15 1
40 31578032 Increased expression of heme oxygenase-1 suppresses airway branching morphogenesis in fetal mouse lungs exposed to inflammation. Pediatr Res 2020 Feb 1
41 31740582 Ferroptosis is controlled by the coordinated transcriptional regulation of glutathione and labile iron metabolism by the transcription factor BACH1. J Biol Chem 2020 Jan 3 7
42 32311410 Downregulation of BACH1 Protects AGAINST Cerebral Ischemia/Reperfusion Injury through the Functions of HO-1 and NQO1. Neuroscience 2020 Jun 1 6
43 32534099 Treatment of dilated cardiomyopathy in a mouse model of Friedreich's ataxia using N-acetylcysteine and identification of alterations in microRNA expression that could be involved in its pathogenesis. Pharmacol Res 2020 Sep 1
44 32534959 Defective BACH1/HO-1 regulatory circuits in cystic fibrosis bronchial epithelial cells. J Cyst Fibros 2021 Jan 1
45 32850850 Bach1 Inhibition Suppresses Osteoclastogenesis via Reduction of the Signaling via Reactive Oxygen Species by Reinforced Antioxidation. Front Cell Dev Biol 2020 4
46 33238752 BTB and CNC homology 1 inhibition ameliorates fibrosis and inflammation via blocking ERK pathway in pulmonary fibrosis. Exp Lung Res 2021 Feb-Mar 2
47 33503260 BACH1 recruits NANOG and histone H3 lysine 4 methyltransferase MLL/SET1 complexes to regulate enhancer-promoter activity and maintains pluripotency. Nucleic Acids Res 2021 Feb 26 1
48 33596919 Chronic intermittent hypoxia promoted lung cancer stem cell-like properties via enhancing Bach1 expression. Respir Res 2021 Feb 17 5
49 34737234 Bach1 derepression is neuroprotective in a mouse model of Parkinson's disease. Proc Natl Acad Sci U S A 2021 Nov 9 4
50 35050486 Metformin exerts an antitumoral effect on papillary thyroid cancer cells through altered cell energy metabolism and sensitized by BACH1 depletion. Endocrine 2022 Apr 8